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Showing 1 to 1 of 1 for “"mdm2; metabolism; drug resistance; tfam; oncogene addicted"”.

  1. INTERPLAY BETWEEN MDM2 AND TFAM REGULATES OXIDATIVE PHOSPHORYLATION IN DRUG-RESISTANT ONCOGENE-ADDICTED CANCERS

    EU JIE QING2022

    … (TKI) remain the first-line treatment for most oncogene-addicted cancers. However, prolonged exposure to TKI could lead to development of resistance. There is mounting evidence of OXPHOS dependency as a mechanism of TKI resistance, but the cause of this metabolic switch remains elusive. Here, we …

    nus Repository record