Global ETD Search
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Showing 1 to 4 of 4 for “"maytansine"”.
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NOVEL MICROTUBULE TARGETING AGENTS: SYNTHESIS AND STRUCTURAL DETERMINATION OF THEIR INTERACTIONS
… is a valuable precursor for the preparation of maytansine derivatives. Thus, one of the main objectives was to establish synthetic routes for the functionalization of maytansinol and to synthesize a set of maytansine analogues with different side chain substituents in C3-position, in order to …
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COMPUTER-AIDED MOLECULAR DESIGN AND MODELING OF TUBULIN TARGETING AGENTS
… IV is described the study performed on the maytansine binding site of tubulin. We computationally designed long-chain maytansinoids and maytansinoid conjugates. Using molecular docking, we predicted the binding mode of short-chain maytansinoids within the maytansine site. Our study reports …
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Synthesis and evaluation of novel heterocyclic compounds as anticancer agents
… the colchicine, vinca alkaloids, rhizoxin/maytansine and tubulin sulfhydryl binding sites. Combretastatin A-4 is one of the mostpotent natural products targeting tubulin and prevents microtubule polymerisation thatleads to mitosis arrest and apoptosis in endothelial cells. Moreover, it can …
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NF1 AS A REGULATOR OF CYTOSKELETON DYNAMICS AND BIOMARKER FOR DECISION-MAKING IN HER2-POSITIVE BREAST CANCER
The tumour suppressor NF1 is best characterised as a canonical negative Ras regulator, but sparse evidence suggests additional Ras-independent roles. The interaction of its product neurofibromin with both microtubule (MT) and actin cytoskeleton remains poorly characterised to date but may be of …