Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"matrix-assisted laser desorption ionisation-time-of-flight mass spectrometry"”.
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The discovery of a novel peptide, QUB-2023, from Rana amurensis
… skin secretions have raised the interest of many researchers not only because of their broad spectrum of actions against many clinically-relevant microorganisms but also their superiority over conventional antibiotics.<br/><br/>This investigation has led to the discovery of a novel peptide …
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Identification and functional study of a novel bioactive peptide QUB-1761 from the venom of the Brazilian yellow scorpion, Tityus serrulatus
Scorpion venom contains a variety of peptides exerting broad bioactivities. In this thesis, QUB-1761, a non-disulphide bridged peptide (NDBP), was discovered in the venom of the Brazilian yellow scorpion, Tityus serrulatus (T. serrulatus). The peptide was identified through molecular cloning by …
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The discovery and functional study of a novel bioactive peptide, QUB-2561, from the defensive skin secretion of the Central American red-eyed leaf frog, Agalychnis callidryas.
… was found from the defensive skin secretion of the Central American red-eyed leaf frog, Agalychnis callidryas by “Shotgun” cloning. Because of the limited quantity of the secreted peptides, the peptide replicate was firstly synthesised via solid-phase peptide synthesis and validated by …
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The discovery and bioactivity evaluation of a novel peptide, QUB-2652, from the skin secretion of the South American frog, Phyllomedusa palliata
In recent years, the antibiotic resistance of bacteria has stimulated the development of new antibiotics. Antimicrobial peptides (AMPs) from amphibian skin secretions possess broad-spectrum antimicrobial activities through the mechanism that is unlikely to induce antibiotic resistance. Thus, AMPs …
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The discovery of a bioactive peptide, QUB-1957, from the defensive skin secretion of the Chinese piebald odorous frog, Odorrana schmackeri
… for new alternatives to antibiotics as one of the hottest topics nowadays. The frog skin secretion may be a potential source where increasing numbers of antimicrobial peptides (AMPs) have been discovered.<br/><br/>In this study, we discovered a novel peptide QUB-1957 from the skin secretion …
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Proteomic analysis of biomarkers associated with immunotherapy in murine tumour models
Emergence of proteomics and high-throughput technologies has allowed the identification of protein expression patterns of disease that potentially hold clinical importance in predictive medicine. The analysis of complex data generated by these technologies incorporates the use of computer …
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The discovery and functional study of an antimicrobial peptide QUB-1955 from the skin secretion of the northern orange-legged leaf frog, phyllomedusa hypochondrialis
Due to the increasing resistance of bacteria to conventional antibiotics, new antimicrobial drugs need to be discovered urgently. Natural active substances extracted from skin secretions of anurans have attracted much interest in recent years. Among them, anti-bacterial peptides with broad-spectrum …
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Identification and functional study of the bioactive peptide QUB-2830 from the skin secretion of the blue-side leaf frog, Agalychnis annae
With the failure of traditional antibiotics in recent years, it is urgent to find new antimicrobial drug. Antimicrobial peptides (AMPs) secreted from amphibian skin have many important bioactivities and act as the first line to defence against invading microorganisms. The aim of this project is …
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Identification and evaluation of the bioactive peptide QUB-2925 from the defensive skin secretion of Phyllomedusa tomopterna
… invasion. Due to the long-term and frequent use of traditional antibiotics, there is an urgent need to seek new drugs to resist drug-resistant microorganism, so cationic AMPs are attracting more and more attention. In this thesis, QUB-2925 is described as a Dermaseptin superfamily peptide derived …
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The colonialisation of paint films by microorganisms in the UK and Norway
… undertaken in order to study the colonisation of paint films by microorganisms. Quantitative data derived from a range of analytical techniques has provided information on surface changes occurring in the paint films during colonisation in the field and during laboratory exposure experiments. …
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The identification of prostate cancer associated tumour antigens and biomarkers
The widespread use of Prostate Specific Antigen (PSA) testing has resulted in the over detection and over treatment of potentially indolent disease due to the lack of specificity of PSA for prostate cancer (PCa). PROTEOMEX, a method of tumour associated antigen (TAA) identification, combines the …
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The role of struvite crystals and the necrobiome in estimating the postmortem interval for forensic investigations in the UK
Forensic taphonomy is a sub-discipline of forensic anthropology and has become a focal point for research in recent years to aid in the development of decomposition models specific to the United Kingdom (UK). Research in the UK has highlighted struvite crystal precipitation as a potential …
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Analysis and characterisation of human chorionic gonadotropin glycoforms in pregnancy and trophoblastic disorders
… glycoprotein hormone with a varying degree of carbohydrate moieties. Its glycosylation arrangements are increasingly recognized as a common and important element of disease pathophysiology and are associated with many disorders including gestational trophoblastic diseases (GTDs). This study …
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Thin layer chromatography-matrix assisted laser desorption ionisation-mass spectrometry of pharmaceutical compounds.
Thin-layer chromatography (TLC) is of great importance for the pharmaceutical industry as a simple, quick, and low cost analytical method. Considerable effort has been made over the past decades to combine the simplicity of TLC with the selectivity and sensitivity of mass spectrometry (MS) …
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Computational methods in palaeoproteomics: making the most of mass spectrometry data
… that hinder progress in zooarchaeology by mass spectrometry (ZooMS) and liquid chromatography electrospray ionisation tandem mass spectrometry (LC-ESI MS/MS) based palaeoproteomics on ceramics, advocating for the development of open-source, community-driven, collaborative, and interoperable …
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The proteomic analysis of resistance to anticancer therapy in human breast cancer
… a major barrier in the successful management of human breast cancer. The identification of novel biomarkers that correlate with treatment response would increase our understanding of the resistance mechanisms and may allow therapy to be tailored on an individual patient basis. Those patients …
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Modifizierung von Glas- und Titanoberflächen zur Verbesserung der Biokompatibilität
The goal of this study was the improvement of the biocompatibility of glass and titanium by surface modification. In biomaterial science glass is applied, for example, in biomedical sensors or optical waveguides. The functionality of these medical devices may be reduced by unspecific protein …