Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"matrix remodelling"”.
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The role of extracellular matrix remodelling in brown adipose tissue functions: New candidates
… status and functionality of the extracellular matrix (ECM). However, the main obstacle is that obese and diabetic patients have less active BAT mass. Understanding the mechanisms that regulate and impair BAT activity in obesity is essential for developing an efficient strategy to increase BAT …
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Nuclear and Molecular Imaging Modalities for Predicting Calcific Aortic Valve Disease Progression in Animal Models
… of particular interest is the expression of matrix metalloproteinases (MMPs) (specifically MMP-1, -2, and -9) which are upregulated in CAVD prior to calcification events and have been previously shown to serve as an attractive molecular imaging target.1–3 The primary objective of this study …
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
… including immune suppression, extracellular matrix remodelling, and neoangiogenesis, that, while detrimental in cancer, could be harnessed for promoting tissue regeneration following neurotrauma. Moreover, studies conducted in our laboratory further identified that TAMs are endowed with a …
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Studies on Macrophage Migration in Pathological Contexts
… invasion of macrophages though an extracellular matrix. The well-characterised Sigma-1 Receptor chaperone, previously implicated in BDNF function, was shown to be an important overall regulator of macrophage invasion, and to be potentially implicated in BDNF suppression of ATP-induced invasion. …
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Modulation of Inflammation Driven Wound Healing after Glaucoma Surgery
… exposure resulted in more ordered extracellular matrix remodelling, less cell-mediated collagen contraction and greater impairment of myofibroblast associated protein expression. We hypothesized that these differences were due to NSAIDs more specific targeting of COX enzyme activity. By sparing …
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Effect of autologous macrophage therapy in cirrhosis in response to individual immune reparative pathways: developing a novel therapy
… cytokine signals may support extra cellular matrix remodelling effect of the autologous macrophage product infusion. In addition we demonstrated a reproducible protocol for MRS in liver disease. DISCUSSION: Autologous activated macrophage infusion did not result in any toxicity in cirrhotic …
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Ex-vivo-Expansion perikardialer Patchstrukturen : zur Frage des Einflusses von zyklischem Stress und laminaren Strömungsbedingungen auf das Ex-vivo-Remodelling perikardialer Patchstrukturen
… cell migration and proliferation. Extracellular matrix- (ECM) composition was analysed in all samples using routine histological and immunohistochemical techniques. RESULTS: Under stimuli of cyclic stress the neo-tissue synthesis has shown cell necrosis and scaffold dissections while under …
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The importance of the tissue transglutaminase-fibronectin heterocomplex in the RGD-independent cell adhesion and fibronectin matrix deposition
… can be secreted and deposited into extracellular matrix, where it forms a heterocomplex (TG-FN) with the abundant matrix protein fibronectin (FN). A further cellular response elicited after tissue damage is that of matrix remodelling leading to the release of the Arg-Gly-Asp (RGD) containing …
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Defining the pro-tumour impact of the evolving stromal microenvironment
… development of tumour-promoting inflammation and remodelling the extra-cellular matrix (ECM). However, recent investigations have shown these functions belong to defined populations that differ between tumour types. This project aimed to investigate stromal heterogeneity across melanoma …
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In Vitro Remodeling of Extracellular Matrix Following Mild Traumatic Brain Injury
… mechanical interplay between the extracellular matrix (ECM) and astrocytes following a simulated mTBI. Cellular mechanisms underlying mTBI and the contribution of mechanical forces that result in prolonged brain damage are yet to be comprehensively understood. Successfully devised mechanical …
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Engineering hiPSCs to enhance neural progenitor transplantation in degenerative cervical myelopathy
… the extent of astrogliosis and extracellular matrix remodelling that could limit or enhance neural progenitor cell (NPC) graft efficacy in DCM is unknown. The first aim of this project was to examine changes in the extracellular matrix in DCM. Immunohistochemistry of post-mortem patient tissue …
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The Role of Type VIII Collagen in Fibrous Cap Formation and Progression of Atherosclerosis
… of atherosclerosis. Collagen synthesis and remodelling influence inflammation, smooth muscle cell (SMC) proliferation and migration, and properties such as plaque tensile strength and mechanical stability. Type VIII collagen is expressed at low levels in the arterial system however, it is …
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Hepatic stellate cell heterogeneity and function during the hepatic regenerative response
… during liver injury and regeneration, driving matrix remodelling and impacting proliferation and differentiation of other hepatic cell types2,3. Traditionally HSCs were considered a homogenous population, with global inhibition reducing hepatic regeneration4,5, but recent single cell RNA …
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Angiogenesis and angioregression gene expression analyses in swine corpus luteum
… vascular invasion and apoptosis process, the remodelling of the extracellular matrix is essential for the correct evolution of the CL, particularly by the action of specific class of proteolytic enzymes known as matrix metalloproteinases (MMPs). Another important factor that plays a role in …
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Genomic and metabolomic interrogation of body composition and insulin resistance endotypes
… strongest signals highlighted an extracellular matrix/remodelling theme (including multiple ADAMTS/ADAMTS-like family genes), alongside exemplars with mechanistically informative profiles such as ATP2A1 (lean-mass-aligned with supporting biochemical associations) and GH1 (opposite-direction …