Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"matrix remodeling"”.
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Aging Effects on Arterial Mechanics and Matrix Remodeling
… structure composed of cells and extracellular matrix proteins. Passive arterial mechanical behavior is determined by the composition of extracellular matrix proteins, in particular elastin and collagen. Elastin provides reversible elasticity to the large elastic arteries during cyclic loading …
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RHAMM Alters Vascular Smooth Muscle Cell Constrictive Matrix Remodeling
… failures. Intimal hyperplasia and constrictive remodeling are the two primary structural mechanisms that lead to restenosis. Constrictive remodeling refers to artery wall shrinkage independent of new wall mass formation after arterial intervention. The purpose of the studies described in this …
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Effects of Asthma Combination Therapy on Extracellular Matrix Remodeling in Human Lung Fibroblasts
… mediators, cytokines and extracellular matrix (ECM) proteins perpetuating the inflammation in the airways of asthmatics. Airway remodeling is also a prominent feature of asthma that affects the lung function causing a thickening of the airways. An increased ECM production of …
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Sex Specific Gene Expression Profiles In Fibrosis and Copd
… related to immune regulation and extracellular matrix remodeling, important events involved in IPF and COPD, have been measured in lung cells and tissues however limited investigations have probed the expression of genes related to steroid hormone signaling between men and women. We hypothesize …
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Multi-Omics Analysis of 3D SKOV3 Ovarian Cancer Model Cell line Cultured on Novel Silicon-Titanium Diboride Micropatterned Substrate
… so, important features like cell-cell and cell- matrix interactions are not properly represented. Gene expression, metabolism, and cell proliferation are altered in 2D culture systems. Unlike the conventional 2D culture systems, 3D culture systems better recapitulate the in vivo architecture and …
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INDUCIBLE CELL EXPRESSION OF MMP1A FOR TUNABLE DEGRADATION OF BIOMIMETIC SCAFFOLDS
… and growth factors for endothelial cell homing, matrix remodeling, and proliferation. In order to tune scaffold properties for optimal angiogenic-promoting conditions, material parameters must be adjusted. In this project, a cellular platform was generated to probe a single aspect of the system, …
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Role Of Substrate Stiffness In Driving Atherogenic Behavior In Macrophages.
… the effect of physical stiffness and associated matrix remodeling on macrophages can now be studied. Herein I describe the effects of physical substrate stiffness on macrophage behavior relevant to atherosclerosis plaque formation using a polyacrylamide hydrogel-based in vitro model of …
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Purification and Characterization of an Anti-Basigin Monoclonal Antibody: Application to the Study of Human Uterine Cells and Tissues
… including cell communication and extracellular matrix remodeling (Chen et al., 2009; K. Li & Nowak, 2020). <em>In vitro</em> studies using human uterine cells demonstrate that basigin-2 regulates the expression and secretion of enzymes called matrix metalloproteinases, which are critical for …
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Extracellular Vesicles as Mediators of Communication Between Endothelial Cells and Fibroblasts
… fibroblasts undergo robust proliferation and matrix remodeling. Although fibroblast activation often coincides with angiogenesis, the mechanisms of endothelial-fibroblast cross-talk remain poorly defined. One emerging mode of intracellular communication is through extracellular vesicles (EVs), …
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Roles of PKR in High Grade Serous Ovarian Cancer
… under three-dimensional and extracellular matrix-engaging conditions. In-vivo, PKR-deficient cells exhibited reduced metastatic dissemination and delayed tumor progression in both immunodeficient and syngeneic mouse models. Proteomic analyses of ascites and tumor-derived samples revealed …
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An immune-competent microvascularized human lung-on-chip device for studying immunopathologies of the lung
… in significant lymphopenia, extracellular matrix remodeling, and transcriptional shutdown in fully immune-competent lung tissues. Lastly, we highlight the prominent role of stromal-immune interactions in the response to severe influenza infection, with stromal cells participating in both …
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Cd44-Mediated Collagen Remodeling Drives Wound Resolution And Pancreatic Tumorigenesis
… of mesenchymal stromal cells, and extracellular matrix (ECM) remodeling. Deregulation of these processes, resulting in chronic inflammation or aberrant accumulation of ECM components, such as fibrillar collagen or hyaluronic acid (HA), contributes to exacerbated scar formation and promotes …
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Lesioni degenerative e meccanismi di riparo della superficie oculare: lo pterigio e le deficienze delle cellule staminali del limbo (LSCD). Studio immunoistochimico e tecniche di coltura cellulare
… fibrosis, angiogenesis and extracellular matrix remodeling. The Angiotensin converting enzyme (ACE or ACE I) is the major component of the Renin-angiotensin system (RAS) converting the inactive decapeptide Angiotensin I (Ang I) to the active octapeptide Angiotensin II (Ang II). Besides …
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Skeletal muscle pericyte response to acute and chronic electrical stimulation
… satellite cell activation, and extracellular matrix remodeling post-acute stimulation. Finally, a pericyte to MSC transition was also observed with 4 weeks of stimulation, but no changes in overall pericyte quantity were noted at 4 or 9 weeks. CONCLUSION: This study provides evidence that …
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Quantitative estimates of mechanical properties from in vivo tumors of rodent animals
… processes characterized by extracellular matrix remodeling and stiffening. This thesis focuses on using ultrasonic tools to image shear waves generated in spontaneous rodent mammary tumors to estimate the complex shear modulus under realistic conditions, and to assess the sensitivity for …
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Tendon Regeneration: Roles of Growth Factors and Phenotypic Diversity in Tendon Stem Cells
… to injury and promote synthesis of collagen and matrix remodeling, among other extracellular processes. Recent evidence suggests that these cells exist on a spectrum of differentiation potencies, and may be differently committed to the tendon fate. Individual stem cells were isolated from the …
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Regulation and inhibition of pro-tumorigenic microenvironments
… cells, immune cells, the extracellular matrix and fibroblasts can all assume a pro-tumorigenic phenotype.</p><p>Like cancer-associated fibroblasts (CAFs), senescent cells promote all stages of tumor development and progression. We and others have demonstrated that senescent fibroblasts …
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Functional Biological Spectroscopy and Multiphoton Imaging Using Endogenous Optical Contrast
… with collagen fibrils with SHG, the dynamics of matrix remodeling were assessed during sprouting events and neovessel growth. A dramatic reorganization of the collagen fibrils by early sprouts and differential collagen remodeling by neovessels was observed, revealing endothelial/matrix events …
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The cell-secreted microenvironment : shaping embryonic stem cell self-renewal and differentiation
… differentiation, and further demonstrate that remodeling the endogenous extracellular matrix halts the exit from the self-renewing state that occurs in mESCs growing under perfusion. Matrix remodeling is then shown to be both necessary and sufficient for maintaining mouse embryonic stem cell …
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