Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"matrix proteases"”.
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Chondrocyte response to in vitro mechanical injury and co-culture with joint capsule tissue
… models have been shown previously to result in matrix damage and decreased biosynthesis by the chondrocytes. We measured gene expression levels of matrix molecules and matrix proteases and found them to be expressed in control cartilage at levels ranging over five orders of magnitude, and to be …
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In vitro models of cartilage degradation following joint injury : mechanical overload, inflammatory cytokines and therapeutic approaches
… the combined effect of TNFa and IL-6/sIL6R on matrix degradation and chondrocyte gene expression in mechanically injured cartilage, and to investigate whether cartilage degradation could be inhibited by potential therapeutic approaches. TNFa and IL-6/sIL-6R interacted to cause …
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Molecular pathway analysis and therapeutics development in post-traumatic osteoarthritis
… TNFa. In turn, these cytokines cause decreased matrix synthesis by chondrocytes and contribute to reprogramming of chondrocytes and synovial cells to increase release of matrix proteases. PTOA accounts for 12% of the OA population and typically affects younger individuals. The first part of this …
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Migration of tumor cells and leukocytes in extracellular matrix : proteolytic and nonproteolytic strategies for overcoming tissue barriers
The extracellular matrix within connective tissues represents a structural scaffold as well as a barrier for motile cells, such as invading tumor cells or passenger leukocytes. It remains unclear how different cell types utilize matrix-degrading enzymes for proteolytic migration strategies and, on …