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Showing 1 to 20 of 121 for “"matrix metalloproteinases"”.
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MATRIX METALLOPROTEINASES AND LEFT VENTRICLE MASS AND FUNCTION
… studies have suggested the pivotal role of matrix metalloproteinases and NT- pro BNP in the pathogenesis of LV remodelling. Our objective was to establish a biomarker of cardiac extra cellular matrix (ECM) degradation that can be used to better identify asymptomatic individuals with …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… role in cancer cell migration and invasion. The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules, and to perform key functions in tumor progression, and …
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Matrix Metalloproteinases 2 and 9 in Normal Canine Cerebrospinal Fluid
… specific, but more information can be obtained. Matrix Metalloproteinases (MMPs) are enzymes that have been found in human CSF. They are calcium and zinc dependent endoproteinases with overlapping substrates. They hydrolyze at least one component of tissue extracellular matrix (ECM), such as …
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Role of matrix metalloproteinases in regulation of late embryonic healing process
… Pivotal role in the wound healing is given to matrix metalloproteinases (MMPs). These remodelling enzymes are important for releasing cytokines, inducing apoptosis, and degradation of extracellular matrix. Our laboratory performed temporal RNA-sequencing of the healing tissue using tailbud …
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Membrane-bound Matrix Metalloproteinases Influence Reactive Synaptogenesis Following Traumatic Brain Injury
… synaptogenesis, a process influenced by matrix metalloproteinases (MMP) and their substrates. Here we report results of studies examining the expression and potential role of two membrane-bound MMPs, membrane-type 5-MMP (MT5-MMP) and a disintegrin and metalloproteinase-10 (ADAM-10), along …
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Matrix metalloproteinases in the equine systemic inflammatory response: implications for equine laminitis
Laminitis is a crippling and often life-threatening disease of the equine foot. Soft tissue damage characteristic of this disease has been associated with increased MMP activity. Therefore, it seems likely that MMPIs could be potential therapeutic agents for laminitis. Further characterization of …
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Mathematical Modelling of Cancer Growth and Spread: The Role of Matrix Metalloproteinases
… approach to protease-dependent invasion where matrix degrading enzymes cleave collagen fibrils and other ECM components. Specifically, in Chapter 4 we formulate a PDE model of cancer cell invasion primarily through haptotaxis as the result of degradation of tissue from the proteolytic activity …
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Visualizing the Spatial Localization of Active Matrix Metalloproteinases (MMPs) using MALDI Imaging MS
… including cytokines, chemokines, and matrix metalloproteinases (MMPs). The nature of the FBR requires the spatial and temporal regulation of these mediators. MMPs are an extremely large and diverse group of enzymes that play key roles in regulating the FBR. Precise spatiotemporal …
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Proteomic Profiling of Pro and Active Matrix Metalloproteinases using Tandem Mass Spectrometry. Optimization of Affinity Chromatography and nHPLC-MALDI-MS/MS for Proteomic discrimination of Matrix Metalloproteinases in pre-clinical Cancer Model.
Matrix metalloproteinases (MMPs) network with other biological molecules to maintain the extracellular matrix (ECM) in normal physiology and perform different roles. Understanding and assigning specific role to each of 24 members of these endoproteinases is impeded because of lack of specific and …
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Matrix Metalloproteinases Regulate The Differentiation Of Adipose-Derived Mesenchymal Stem Cells Into Endothelial Cells
… of intravascular stenting to prevent restenosis. Matrix metalloproteinases (MMPs) have critical role in the differentiation of MSCs to different lineages. Identifying the molecular factors and mechanisms that regulate AMSCs differentiation to endothelial cells (ECs) is important in the promotion …
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Regulation of Matrix Metalloproteinases and Their Inhibitors by DNA Methylation in Human Gestational Tissues
… thus providing novel therapeutic avenues. Matrix metalloproteinases (MMPs) and specific endogenous tissue inhibitors of metalloproteinases (TIMPs) are key mediators of fetal membrane rupture during physiological and pathological labour. Membrane type MMPs (MT-MMPs) activate secreted MMPs in …
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Extracellular Matrix Metalloproteinase Inducer (Emmprin) Regulates Matrix Metalloproteinases in Human and Baboon Uterine Endometrium
Human epithelial endometrial cells secreted a full-length functional form of EMMPRIN that stimulated stromal expression of MMP-1,-2 and -3 but not EMMPRIN. We also found that endogenous stromal cell expression of EMMPRIN was important but not required for MMP stimulation.
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Effects of cytokines and monocytes on matrix metalloproteinases in human vascular smooth muscle cell cultures
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1995.
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The role of matrix metalloproteinases and their inhibitors in irinotecan-induced oral mucositis: an animal model.
… A group of proteolytic enzymes called matrix metalloproteinases (MMPs) have been recently postulated to play a part in mediating the damaging process seen in oral mucositis. It is well established that MMPs and their naturally existing inhibitors (tissue inhibitors of …
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Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinases (MMPs) as biomarkers of bladder cancer development and progression
… It positively modulates the activity of the matrix metalloproteinases-9 (MMP-9) that are involved in the enzymatic remodelling of the extracellular matrix. MMP-9 regulates the degradation of extracellular matrix in processes such as angiogenesis, tumour growth, and metastasis. By forming the …
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Abdominal aortic aneurysms : identification by self-examination and analysis of variation in matrix metalloproteinases with peak wall stress
… may provide an economic and practical solution. Matrix metalloproteinase (MMP) concentration is elevated and levels of their natural inhibitors - Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) are reduced at sites of AAA rupture. Finite element analysis (FEA) of AAAs can define the area …
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The Degradation of Resin Materials Bonded to Dentine in the Root Canal by the Activation of Matrix Metalloproteinases
… based dental restorative materials. Dentine matrix metalloproteinases have been associated with this leakage through their involvement in the proteolytic degradation of the resin-dentine hybrid layer. The inhibitory effect of chlorhexidine on this enzymatic activity is well established. …
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The Examination of Leptin Receptors, Matrix Metalloproteinases-2 and -9 and Tissue Inhibitors of Metalloproteinases in the Rat Cervix
… and whether leptin has a role in regulating two metalloproteinases (MMP-2 and -9), enzymes known to be involved in collagenolysis. Furthermore, the expression of these metalloproteinase enzymes and their associated inhibitors was examined. Results reported herein show that three of five leptin …
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