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Showing 1 to 20 of 136 for “"matrix metalloproteinase"”.
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BIOSENSING OF MATRIX METALLOPROTEINASE ACTIVITY WITH CD-FREE QUANTUM DOTS
… low toxicity, and the ability to detect active matrix metalloproteinase (MMP) in a biosensing system, designed to identify direct biomarkers for pathological conditions, which in turn would enable early disease diagnosis and better treatment development. In this work, highly luminescent …
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Regulation Of Membrane-Type 1 Matrix Metalloproteinase In Prostate Cancer
Membrane type-1 matrix metalloproteinase (MT1-MMP) is a metalloproteinase which becomes upregulated in prostate cancer and has been implicated in processes of prostate cancer metastasis. Here, we show that MT1-MMP is minimally expressed in nonmalignant primary prostate cells, moderately expressed …
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Transcriptional Regulation of Matrix MetalloProteinase-3 in Rat Brain Astrocytes.
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matix (ECM) components during normal and pathogenic condition. Documented expression of MMPs contributes to tissue remodeling, atherosclerosis, and inflammatory diseases. MMPs are tight regulated by …
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Functional Consequences of Matrix Metalloproteinase-1 Over-Expression in Human Gliomas
… to their ability to invade surrounding tissue. Matrix metalloproteinases are thought to contribute to the invaseive phenotype of human gliomas. Absent in normal brain, matrix metalloproteinase-1 (MMP-1) has been shown to be present in gliomas, and in particular in glioblastoma multiforme (GBM). …
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Synthesis and characterization of matrix metalloproteinase sensitive hydrogels for articular cartilage engineering
… fumarate), developed in our laboratory. A matrix metalloproteinase sensitive peptide was used to crosslink the macromer, allowing for enzymatic degradation of the hydrogel and providing more void space for the production and deposition of extracellular matrix. Various formulations of OPF …
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The Expression of Matrix Metalloproteinase-9 and -2 in Olfactory Injury and Recovery
… of the olfactory bulb (OB) remain unknown. The matrix metalloproteinases (MMPs) are important components in many central nervous system (CNS) injury paradigms, yet remain unexplored in olfactory injury and recovery. To address the role of MMPs, the temporal expressions of MMP-9 and MMP-2 were …
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Investigation of the functions of Matrix Metalloproteinase-8 (MMP-8) in Mammary Carcinoma Cells
… breast cancer require better understanding. The matrix metalloproteinases (MMPs) are a family of proteases thought to promote metastasis due to their matrix degradation capabilities. MMP-8 however has been discovered to be anti-tumourigenic in many cancers, and anti-metastatic in breast cancer. …
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Extracellular Matrix Metalloproteinase Inducer (Emmprin) Regulates Matrix Metalloproteinases in Human and Baboon Uterine Endometrium
Human epithelial endometrial cells secreted a full-length functional form of EMMPRIN that stimulated stromal expression of MMP-1,-2 and -3 but not EMMPRIN. We also found that endogenous stromal cell expression of EMMPRIN was important but not required for MMP stimulation.
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Expression, activation, and regulation of matrix metalloproteinase 2 (MMP-2) in the bovine corpus luteum
<p>Matrix metalloproteinases (MMPs) have been postulated to be important for angiogenesis and for tissue remodeling events associated with corpus luteum (CL) development. The MMPs are mainly regulated at three levels, transcription, activation, and inhibition by endogenous tissue inhibitors of …
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Determination of the role and regulation of matrix metalloproteinase-25 during mouse secondary palate formation
… is one of the most common birth disorders. The matrix metalloproteinases (MMPs) are required for proper SP development, but a functional role for any one of them remains unknown. MMP-25 is a candidate MMP to have a functional role in SP formation as genetic scans of the DNA of human cleft palate …
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CANNABINOID RECEPTOR 2 AGONIST REDUCES IMMUNE CELL MIGRATION IN NEUROINFLAMMATION VIA INHIBITION OF MATRIX METALLOPROTEINASE-9
… levels of the adhesion molecule VCAM-1 and matrix metalloproteinases MMP-2 and 9 at peak of EAE in treated mice. The decrease in VCAM-1 correlates with our previous observation of decreased leukocyte rolling and adhesion to brain microvasculature. However, the reduction in MMP-2/9 expression …
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The Influence of a Single Nucleotide Polymorphism In The Matrix Metalloproteinase-1 Promoter on Glioma Biology
… responsible for this invasive nature include the matrix metalloproteinase family. MMP-1 is a member of this family which has been well studied in many types of invasive tumors, with gliomas being an exception. We studied a single nucleotide polymorphism (SNP) in the MMP-1 promoter that may …
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The regulation of matrix metalloproteinase (MMP) secretion in human vascular cells exposed to extracellular and wound matrices
… in wounds during healing. The regulation of matrix metalloproteinases (a key superfamily of proteases involved in the above process) by wound healing components is an area of ongoing investigation. However, a systematic study of the exposure of the human derived vascular cells - endothelial …
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Coronary Artery Outcome in Kawasaki Disease: The Role of Matrix Metalloproteinase-9 and Therapeutic Modulation of Its Activity
… increased enzymatic activity of the elastase, matrix metalloproteinase (MMP)-9. MMP-9 protein and activity levels were elevated in the heart post-disease induction. Expression and activity were specific for and localized to inflamed coronary arteries. The pro-inflammatory cytokine, tumour …
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The Expression of Neutrophil Products, Myeloperoxidase and Matrix Metalloproteinase 8, in Systemic Vasculature of Obese and Preeclamptic Women
… neutrophil products, myeloperoxidase (MPO) and matrix metalloproteinase 8 (MMPS), was associated with neutrophil infiltration in systemic vascular tissue of obese and preeclamptic women. I tested my hypotheses by using immunohistochemical studies to look at the expression of MPO and MMP8 in the …
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Transient collagen triple-helix binding to membrane type 1 matrix metalloproteinase : interaction studies and NMR-guided structural docking
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] MT1-MMP (MMP-14) as pericellular collagenase is critically involved in cancer cell invasion through collagen barriers that it degrades. To better understand the structural and mechanistic details underlying collagenolytic …
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Matrix metalloproteinase activity and inhibition in articular cartilage : effects on composition and biophysical properties and relevance to osteoarthritis
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1995.
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The Possible Role for Basigin Receptor Function in The Induction of Matrix Metalloproteinase Expression in Human Endometrial Stromal Cells
… is best known for inducing the expression of matrix metalloproteinases. Basigin has been shown to induce MMP expression in vitro in human endometrial stromal cell lines (HESC). Understanding how basigin induces matrix metalloproteinases within normal cellular conditions will help researchers …
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