Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"maternal antibodies"”.
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The Effect Of Maternal Antibodies On Anti-Viral Immunity In Infant Mice
… effective vaccines for this population. While maternal antibodies can provide protection, they also inhibit the infant’s de novo antibody response. Furthermore, maternal antibodies can exacerbate disease in some contexts. Thus we need better vaccination strategies to protect infants. Here, we …
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Interpretation of the Detection of Antibodies to Sarcocystis neurona in the serum and CSF of young horses
… of equine protozoal myeloencephalitis, produce antibodies that are detectable in serum by western blot (WB). A positive test is indicative of exposure to the organism. Positive tests in young horses can be complicated by the presence of maternal antibodies. Passive transfer of maternal …
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INVESTIGATING THE ROLE OF DENGUE-SPECIFIC IMMUNITY IN PROTECTION AND DISEASE USING SYMPTOMATIC MOUSE MODELS
… we investigated the relative contribution of maternal antibodies in disease outcome and identified breastfeeding as the major antibody transfer route. Next, we studied dengue-specific antibody populations present in our symptomatic models and demonstrated that antibodies specific to DENV …
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DEVELOPMENT OF AVIAN PARAMYXOVIRUS VECTORED VACCINES
… agent. For poultry vaccination, the preexisting maternal antibodies against NDV can neutralize APMV-1 vectors resulting in vaccination failure. Hence, there is a need to develop new vaccine vectors that would escape neutralization by the maternal antibodies. In the first part of my study, I …
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Modelling the transmission dynamics of RSV and the impact of routine vaccination
… we identified the duration of RSV specific maternal antibodies, duration of primary and tertiary infections as the most important parameters in explaining the imprecision observed in predicting both the age specific hospitalizations and the optimal month at vaccination. Results from the …
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An Examination of the Safety and Efficacy of Aripo-Zika as a Zika Virus Vaccine Candidate
… vaccination by evaluating passive transfer of maternal antibodies, (ii) the optimal dosage regimen, (iii) anti-vector immunity to the ARPV backbone, and (iv) the effects of boosters on vaccine efficacy. We also evaluated AZ safety via a co-infection study. Our results show a near linear …
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Molecular mechanisms of porcine circovirus 2 replication and pathogenesis
… My objectives were to determine the effect of maternally derived antibodies on PCV2 infection, assess the role of 2 amino acid substitutions in the PCV2 capsid protein in PCV2 attenuation, evaluate the effect of Rep gene exchange between PCV1 and PCV2 on growth characteristics of a chimeric …
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The status of protective measles antibodies in HIV-1 positive and negative infants aged 6 and 9 months in urban Lusaka,Zambia
… in 1966. The age at which passively acquired maternal measles antibodies decay is critical in determining the optimal age for measles vaccination in infants, particularly in HIV exposed infants who may have acquired low maternal antibodies, and even in those who are not HIV exposed. RESEARCH …
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The status of protective measles antibodies in HIV-1 positive and negative infants aged 6 and 9 months in urban Lusaka,Zambia
… in 1966. The age at which passively acquired maternal measles antibodies decay is critical in determining the optimal age for measles vaccination in infants, particularly in HIV exposed infants who may have acquired low maternal antibodies, and even in those who are not HIV exposed. RESEARCH …
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Genetics, humoral immunoresponsiveness, and disease resistance in chickens
… was evaluated by primary, memory, and maternal antibody responses to SRBC. Primary antibody response, measured 5, 10, and 20 days after inoculation with SRBC was greater in HA than LA chicks inoculated at 14, 21, and 28 days of age. In chicks injected at 7 days of age, a higher …
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Behavioral biomarkers for calf health
… behaviors, and measures of passive transfer of maternal antibodies (IgG1, Igm, hematocrit, and total plasma protein). There was a tendency for IgG1 concentrations to have an inverse relationship with calf body weight. Total plasma protein was correlated with IgG1 and IgM. Likewise, hematocrit …
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The modulation of autoimmune disease progression in mouse models
… models. These diseases have circulating autoantibodies that are mostly mutated with an IgG isotype, indicating B cells that are producing them have been through the process of affinity maturation. Activation-induced cytidine deaminase (AID) is a core enzyme that regulates somatic …