Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"maternal age-effect"”.
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STUDIES IN OOCYTES FROM THREE MAMMALIAN SPECIES DEMONSTRATE THAT MEIOTIC KINETOCHORES ARE COMPOSED OF PREVIOUSLY UNIDENTIFIED SUBDOMAINS AND REVEAL TWO NOVEL MECHANISMS BEHIND THE MATERNAL-AGE EFFECT IN HUMANS
… eggs increases strikingly with advancing maternal age. Why egg quality declines dramatically as women approach their forties remains one of the outstanding questions in developmental biology. This PhD thesis demonstrates how unforeseen features of kinetochore organization that are unique …
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Preventing aneuploidy and the consequences of failure
… frequent in humans and are responsible for the 'maternal age effect.' This thesis addresses both the causes and consequences of aneuploidy. We first investigate the mechanisms that ensure faithful segregation of chromosomes during meiosis in the budding yeast Saccharomyces cerevisiae. The …