Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"master-regulators"”.
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Master regulators of neuronal maturation in NGN2 reprogrammed iPSC-derived iNeurons
… on multi-electrode arrays (MEAs). Candidate master-regulators of iNeuron maturation were identified using TF motif prediction tools and a dataset combining ATAC-seq and RNA-seq analysis of a granular time-course experiment during NGN2 reprogramming, in the presence and absence of glia. …
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A framework for understanding heterogeneous differentiation of CD4⁺ T cells
… We show that the mutual inhibitions among the master regulators govern the formation of multi-stability behavior, which in turn gives rise to heterogeneous differentiation. The framework can be applied to systems with two or more master regulators, and models based on the framework can make …
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Regulation of desiccation tolerance in Xerophyta seedlings and leaves
… than seed maturation. Of the canonical seed master regulators (such as the LEC1/ABI3/FUS3/LEC2 network and ABI5) only three ABI3 transcripts were expressed, all of which encoded proteins lacking the seed motif-binding B3-domain. The results of this study suggest that vegetative desiccation …
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Functional Genomics Based Interrogation of Cell-Fate Determination Pathways
… (Hh) and Wnt signal transduction pathways are master regulators of embryogenesis and tissue renewal and represent anticancer therapeutic targets. Using genome-wide RNA interference screening in murine cultured cells, I established previously unknown associations between these signaling pathways …
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Hox Targeting in Vertebrate Forelimb Induction: Expression and Comparative Genomics
<p><em>Hox</em> genes encode master regulators of body plan during embryonic development. In land and avian (bird) vertebrates there are four clusters of <em>Hox</em> genes (A, B, C, D). Patterns of <em>Hox</em> expression (paralogs 5-8), in our work specifically <em>Hoxc5, c6, c8,</em> and …
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Home Sweet Home: Epigenetic Paths of Stem Cells In and Out of Their Niche
… where its stem cells (HFSCs), niche and master regulators are well-characterized. By mapping global chromatin domains of HFSCs in their native niche, and of committed progenitors, I discovered that super-enhancers and their dense clusters ('epicenters') of transcription factor binding …
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Investigations into membrane protrusions mediated by IRSp53 IMD
… IRSp53 acts downstream of cytoskeleton master regulators Rac and Cdc42 in the formation of lamellipodia and filopodia, respectively. IRSp53 interacts with many other effectors in the formation of these structures, via various protein interaction domains. IRSp53 also contains an IMD …
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Quantitative dynamic modeling of transcriptional networks of embryonic stem cells using integrated framework of Pareto optimality and energy balance
… for ESCs which integrates several different master regulators of pluripotency such as transcription factors Oct4, Sox2, Nanog, Klf4, Nacl, Rexl, Daxl, cMyc, and Zfp281, and obtained the dynamic connectivity matrix between various pluripotency related gene promoters and transcription factors. …
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The Role of Arabidopsis thaliana Clade A1 Heat Shock Transcription Factors in Growth and Development
… heat shock transcription factors function as the master regulators of heat shock and other abiotic stresses. Members of this clade (HSFA1a/b/d/e) are highly redundant but have individual and collective functions. Transgenic overexpression of one of its members, HSFA1b, in Arabidopsis was shown to …
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ROLE OF THE HISTONE DEMETHYLASE LSD1 IN THE REGULATION OF DIFFERENTIATION OF ACUTE PROMYELOCYTIC LEUKEMIA CELLS
… target genes by cooperating with many epigenetic regulators. Some of the known epigenetic enzymes involved in the APL pathogenesis also interact with LSD1 in other systems. LSD1 is a demethylase involved in transcriptional regulation, mainly acting on dimethylated lysine 4 of Histone H3 (H3K4me2). …
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Intrinsic Specificity of Binding and Regulatory Function of Class II bHLH Transcription Factors
… we utilize an inducible system to express these master regulatory factors in embryonic stem cells to characterize early events in bHLH factor binding and function in a common cellular context, removed from their role as endogenous master regulators of lineage specification. Using genome-wide …
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The Metabolic Transitions Regulated by the Estrogen-related Receptor (ERR) in Drosophila melanogaster
… conserved estrogen-related receptors (ERRs) are master regulators in controlling metabolic homeostasis, and good candidates for mediating the metabolic transition induced by hypoxia and development. First, we investigate how dERR influences hypoxic adaptation in Drosophila melanogaster. We find …
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The novel roles of BCL6 and BATF3 in regulating human CD8⁺ T cell dysfunction
… that putative BATF3 target genes may include master regulators of exhaustion. Moreover, overexpression of BCL6 or BATF3 markedly upregulates TIM-3 expression and suppressed cytokine release, establishing their capacity to induce T cell dysfunction. We further validated these findings ex vivo …
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MIT/TFE FACTORS CONTROL ER-PHAGY VIA TRANSCRIPTIONAL REGULATION OF FAM134B
… responsive transcription factors TFEB and TFE3—master regulators of lysosomal biogenesis and autophagy—control ER-phagy by inducing the expression of the ER-phagy receptor FAM134B. The TFEB/TFE3-FAM134B axis is activated in chondrocytes by FGF signalling, a critical regulator of skeletal growth. …
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Understanding small RNA-mediated post-transcriptional regulation of Salmonella pathogenicity island 1 activator HilA in Salmonella typhimurium
… used hilA 5' UTR tagging to capture cognate sRNA regulators. Comparative analysis revealed distinct advantages and limitation of each approach for dissecting target-focused sRNA discovery. rGRIL-Seq analysis revealed the potential sponge function of hilA 5’ UTR, identifing an sRNA-mediated SPI-1 …
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Defining the metabolic effect of peroxisome proliferator-activated receptor δ activation
… better characterised the role of the PPARs as master regulators of metabolism and emphasised their potential as therapeutic targets for metabolic diseases of global importance.
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Phosphatase Regulation of Mechanical Stress and Aging in C. elegans
… and influence adaptation. Phosphatases represent master regulators of stress signaling and modulate cellular responses and fate during stress and aging. Yet, physiologically relevant mechanisms by which these phosphatases are regulated or orchestrate stress response and lifespan are incompletely …
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ELUCIDATION OF MECHANISMS GENERATING 5-HYDROXYMETHYLCYTOSINE (5hmC) IN MAMMALIAN MITOCHONDRIA
… expression is upregulated by NRF1 and PGC1α, master regulators of mitochondrial biogenesis and function, as well as by loss of p53. Altered mtDNMT1 expression asymmetrically affects mtDNA transcription. We are now pursuing the role of Tet proteins in generating 5hmC in mtDNA. Using an in vitro …
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