Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 109 for “"mast cells"”.
-
Mast cells in gastrointestinal helminth infection
Helper T cells type 2 (Th2)play an essential role in host protective responses against the gastrointestinal (GI) nematode parasite, Trichinella spiralis. It is believed that mast cell recruitment and activation may be associated with parasite expulsion from mice. In the current study, we …
-
Mast cells affect brain physiology and behavior
Mast cells are immune cells that are found in the brain. Behavioral and endocrine states increase the number and activation of brain mast cells, independent of the animal's immune status. Activation causes the release of many neuro-active mediators into the brain parenchyma. However, the function …
-
Salmonella Suppress Innate Immunity by Targeting Mast Cells
<p>Mast cells (MCs) are increasingly recognized as powerful sentinel cells responsible for modulating the early immune responses to a wide range of infectious agents. This protective role is attributable in part to their preponderance at the host-environment interface and their innate capacity to …
-
New aspects of tissue mast cells in inflammatory airway diseases
Mast cell are found throughout the body, but are especially prominent in tissues that have direct contact with the external milieu such as the skin, gastrointestinal tract and lungs. Mast cells are commonly recognized for their detrimental role in allergic reactions and can, upon activation through …
-
Regulation of TIM-3 Expression in Mast cells and Monocytes
… is expressed on differentiated Th1 cell, mast cell and monocyte. Although expression of TIM-3 and its ligand galectin-9 has been demonstrated in mast cells, the transcriptional regulation of these molecules has not been well explored. Considering the emerging role of mast cells in host …
-
On the role of mast cells in chemokine-induced leukocyte recruitment
… depends on the function of several different cells, including leukocytes, endothelial cells, mast cells and macrophages as well as a wide spectrum of inflammatory mediators, such as TNF-alpha and chemokines. Chemokines are effective leukocyte attractants and according to structural properties, …
-
Neuroimmune Interactions of Enteric Neurons and Mast Cells: Friends or Foes?
… however, local areas containing numerous mast cells were detected in the muscle layers, the serosa and in and around the myenteric ganglia 4-20 weeks post ischemia. Myenteric ganglionic formations within such mast cell rich areas virtually lacked neurons. Myenteric neurons co-cultured with …
-
The study of the role of mast cells in malignant pleural effusion
Although mast cells have been found in multiple malignancies, their functional contribution remains controversial. We found mast cells in mouse and human malignant pleural effusions, and studied their functions. Mouse adenocarcinomas competent of malignant effusions potently chemoattracted and …
-
Role of mast cells in women's health and disorders of the endometrium
… as well as a diverse population of immune cells. Mast cells (MCs) are long-lived tissue resident immune cells characterised by the presence of granules containing proteases. Mast cells have been detected in the human uterus but little is known about their regulation or the impact of …
-
The role of mast cells in a mouse model of focal cerebral ischaemia
… and the leading cause of disability worldwide. Mast cells have been identified as contributors to ischaemic stroke pathology, and are therefore a novel candidate for targeted stroke therapy. Indeed, genetic mast cell deficiency prior to onset of transient middle cerebral artery occlusion (tMCAo) …
-
Interleukin-10 Induces Apoptosis in Developing Mast Cells via a Mitochondrial, STAT3-dependent Pathway
… to determine the effects of interleukin-10 on mast cell development from bone marrow progenitors.Materials and Methods. Unseparated mouse bone marrow cells were cultured in IL-3+SCF, giving rise to mast cells and monocytes/macrophages. The addition of IL-10, and the use of Signal Transducer and …
-
Single Cell Study of Malaria and Antimalarial Drug Impacts on Platelets and Mast Cells
Platelets and mast cells are among the first responders against foreign substances within a biological system. Understanding how the fundamental mechanisms of these two cell types act in a diseased vs. healthy environment is particularly important for any therapeutic approach. By using an …
-
Study of cellular mechanisms of inflammation and the involvement of mast cells in disease
… tool for the study of immune cell signaling. Mast cells, in particular, are an ideal model for this research because 1) they're found in most connective tissues and mucosal surfaces throughout the body, 2) they posses a broad capacity to regulate the immune response and are thought to take …
-
Head Trauma Release of Histamine from Dural Mast Cells Alters Blood-Brain Barrier: Attenuation with Zolantidine
… to specifically identify the role of dural mast cell (MC) histamine in trauma-induced increased permeability in the blood-brain barrier (BBB). A single line was scored partially through the left dorsal parietal skull. Immediately following the trauma, degranulation was seen in 39% of the MCs …
-
Interactions of Mast Cells with the Lymphatic System: Delivery of Peripheral Signals to Lymph Nodes by Mast Cell-Derived Particles
<p>Mast cells, best known for their pathologic role in allergy, have recently been shown to have key roles in the initiation of adaptive immune responses. These cells are located throughout the body just beneath barriers separating host from environment, possess multiple pathogen recognition …
-
Examining the Roles of Membrane Lipids and Secreted Bioactive Lipids on Immune System Cell Function: Studies on Mast Cells and Platelets
… signaling in the function of immune system cells. Lipids, both as the cell-secreted mediators of inflammation and as important structural components of all mammalian cell membranes, have critically important roles in the functions of cells in the immune system. As such, this dissertation …
-
Characterizing Zika and West Nile virus infection in mast cells and the antibody-dependent enhancement potential mediated by dengue virus antibodies
In the dermis, long-lived resident mast cells are well-situated to respond to mosquito-borne pathogens. Within the Flavivirus genus, dengue virus (DENV), Zika virus (ZIKV), and West Nile virus (WNV) are evolutionarily related mosquito-borne viruses with antigenic similarities. The antigenic …
Page 1 of 6