Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"massively parallel reporter assay"”.
-
Pathogenicity and selective constraint in the non-coding genome
… Finally, I conducted a pilot experiment to assay >50,000 different non-coding variants across more than 700 different non-coding elements, including variants observed in patients with developmental disorders in a massively parallel reporter assay (MPRA) and collaborated on an assessment of …
-
Chromatin accessibility informs cell identity: studies in silico, in vitro, and in vivo
… accessibility through the development of a novel massively parallel reporter assay for chromatin accessibility. In collaboration with Budhaditya Banerjee and Rich Sherwood, we identify DNA sequence features and subtle influences of transcription factor ordering within a sequence for tuning levels …
-
Computational regulatory genomics : motifs, networks, and dynamics
… validate the predicted motif instances using a massively parallel reporter assay. We find that the predictions made by our algorithms are of high quality and are comparable to those made by leading experimental approaches. Moreover, we find that experimental and computational approaches are …
-
Developing and applying transient expression systems to identify and understand gene regulatory elements in plants
… I develop transient expression systems to enable massively parallel reporter assays (MPRAs) in crop models. I apply these transient assay systems to identify, characterize and design plant gene regulatory elements. To allow for the scale of MPRAs, I develop a high-efficiency transformation …