Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"mass-action"”.
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In Silico Evolution of Oscillating Mass-Action Chemical Reaction Networks
… of complex systems, including the evolution of mass-action chemical reaction networks. This dissertation explores the application of evolutionary algorithms in this domain, presenting a novel approach inspired by neural network evolution methodologies. A key feature of the algorithm is …
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The role of dosage sensitive genes in aneuploid phenotypes
… the "few critical genes hypothesis" and the "mass action of genes hypothesis". Our results indicate that subtle changes in gene dosage across a chromosome can have significant phenotypic consequences. We conclude that phenotypic thresholds can be crossed by mass action of copy number changes …
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Experiment design for systems biology
… of high-quality models. First, the chemical reactions that control biochemical processes are only partially known, and multiple, mechanistically distinct models often fit all of the available data and known chemistry. We address this by providing methods for designing dynamic stimuli that can …
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Computational modeling techniques for biological network productivity increases : optimization and rate-limiting reaction detection
… differential equation (ODE) model based on the mass-action rate law (MRL) of the biochemical reactions. It describes the detailed biochemical mechanisms of the enzyme reactions, and therefore reflects closely of how the enzymes work in the systems. Because the MRL models are constructed with …
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Modeling of interactions between vascular endothelial growth factor family members and their receptors KDR and Flt-1
… of 12 ordinary differential equations, based on mass action kinetics, which describe, based on mass-action kinetics, the formation and disappearance of receptor-ligand complexes competent to transduce a VEGF signal. Cell-based assays were used to test predictions of the in silico model by …
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Understanding and managing Frogeye Leaf Spot through network-based modeling in soybean
… with yield losses of 30 - 60%. Traditional mass-action models assume homogeneous mixing, which rarely holds in real fields and limits their ability to gain insights into FLS management. To address this, we developed a network-based model that incorporates real-field structure to improve FLS …
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Analysis and Simulation for Homogeneous and Heterogeneous SIR Models
… assumed to behave in accordance with the law of mass action; however, other disease incidence terms also exist in the literature. A homogeneous Susceptible-Infectious-Removed (SIR) model with a generalized incidence term is presented along with analytic and numerical results concerning effects of …
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Modeling The Unfolded Protein Response And Its Connection To Cellular Stress
… initial model of the UPR. This model is based on mass action kinetics. We solve this model deterministically, to look at the concentration profiles of the proteins and protein complexes, upon UPR induction. This kind of study, along with the mathematical and statistical tools developed in the …
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Study of cell-cell communication using 3D living cell microarrays
… transport through the hydrogel, and simple mass-action kinetic equations to simulate the resulting protein expression over time.
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A quantitative framework For large-scale model estimation and discrimination In systems biology
… protein concentrations and rate constants) for mass action models of receptor-mediated cell death. The width of the individual parameter distributions is largely determined by non-identifiability but co-variation among parameters, even those that are poorly determined, encodes essential …
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Pinning control of disease networks
… is known, node-, network- and population mass-action models can be measured for incidence. Two selective pinning control strategies, namely proportional feedback and nonlinear model predictive control (NMPC), are compared with one another and also with a random pinning strategy. The …
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Homogeneous nucleation of water vapor in inert gas atmospheres
… in these cavities results in a substantial interaction energy. The law of mass action is applied to this hydration reaction to achieve the dependence of the nucleation rate on the nature for the carrier gas. Since detailed computations were undertaken for only one cluster size, namely a 57 …
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Mass fluctuation kinetics : analysis and computation of equilibria and local dynamics
The mass fluctuation kinetics (MFK) model is a set of coupled first-order differential equations describing the temporal evolution of means, variances and covariances of species concentrations in systems of chemical reactions. It generalizes classical mass action kinetics (MAK) in which …
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Simulation and optimization tools to study design principles of biological networks
… the combinatorial scaling in the more standard mass-action model was estimated to consist of more that 10⁷ species and was too large to simulate; however, a simplified model consists of only 132 state variables and produced intuitive behavior. The resulting models were utilized to study the …
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A stochastic treatment of reaction and diffusion
… develop a theory for the analysis of chemical reactions in "isolated" containers. The main tool for this analysis consists of Boltzmann maps, which are discrete time dynamical systems that describe the time evolution of the normalized concentrations of the chemicals in the reactions. Moreover, …
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A Monte Carlo study of the scaling of nucleation rates in a Lennard-Jones system
… system and provides insight into the "law of mass action" model assumptions which give rise to the scaling.</p>
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The Automated Construction and Verification of Physically Plausible Models of Physiological Systems
… a Python tool. This tool implements checks for mass, charge, and energy conservation. It automatically reads CellML and SBML models and evaluates their consistency with physical and thermodynamic principles. When applied to the BioModels Database, my tool identified 182 models governed by …
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Distribution and regulation of ion channels in neurons: Quantitative studies of global ion channel transport and homeostatic synaptic scaling
… in both axons and dendrites (Chapters 3 and 5). Mass action models reveal that measured transport profiles corroborate discrepancies in Kv4.2 localization both between neurite types and along the somatodendritic axis (Chapter 4). Exchange between mobile and immobile fractions, inferred from …
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Raymond Mhlaba and the genesis of the Congress Aliance : a political biography
… of life and gave the organisation its broad mass appeal. The thesis therefore examines Raymond Mhlaba as an actor in the founding of the Congress Alliance in Port Elizabeth. It looks at how Mhlaba succeeded in building a firm alliance between the trade union movement, the Communist Party and …
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Physico-chemical properties of polypropylene glycols
… glycol) (PPG) samples of different molecular mass were characterized using differential scanning calorimetry, modulated differential scanning calorimetry, thermogravimetry and thermally stimulated current (TSC) spectroscopy. It was shown, by TSC, that the glass transition temperature and the …
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