Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"mass action kinetics"”.
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Modeling of interactions between vascular endothelial growth factor family members and their receptors KDR and Flt-1
… of 12 ordinary differential equations, based on mass action kinetics, which describe, based on mass-action kinetics, the formation and disappearance of receptor-ligand complexes competent to transduce a VEGF signal. Cell-based assays were used to test predictions of the in silico model by …
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Experiment design for systems biology
… of high-quality models. First, the chemical reactions that control biochemical processes are only partially known, and multiple, mechanistically distinct models often fit all of the available data and known chemistry. We address this by providing methods for designing dynamic stimuli that can …
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Modeling The Unfolded Protein Response And Its Connection To Cellular Stress
… initial model of the UPR. This model is based on mass action kinetics. We solve this model deterministically, to look at the concentration profiles of the proteins and protein complexes, upon UPR induction. This kind of study, along with the mathematical and statistical tools developed in the …
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Mass fluctuation kinetics : analysis and computation of equilibria and local dynamics
The mass fluctuation kinetics (MFK) model is a set of coupled first-order differential equations describing the temporal evolution of means, variances and covariances of species concentrations in systems of chemical reactions. It generalizes classical mass action kinetics (MAK) in which …
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The Automated Construction and Verification of Physically Plausible Models of Physiological Systems
… a Python tool. This tool implements checks for mass, charge, and energy conservation. It automatically reads CellML and SBML models and evaluates their consistency with physical and thermodynamic principles. When applied to the BioModels Database, my tool identified 182 models governed by …
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Towards structure and dynamics of metabolic networks
… availability of detailed kinetic knowledge on reaction rates. It is shown that precise mathematical formulations of problems are needed i) to find appropriate and, if possible, efficient algorithms to solve them, and ii) to determine the quality of the found approximate solutions. Furthermore, …
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Stochastic modelling for control and interconnections of biological systems
Biochemical reactions often occur in small volumes within a cell, restricting molecule numbers to the hundreds or even tens. At this scale, reactions are inherently discrete and stochastic. Traditional models based on differential equations and mass-action kinetics fail to capture the behaviour of …
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Large scale simulation and analysis to understand enzymatic chemical mechanisms
… as a function of up to 6 dimensions, along a reaction path determined through a combination of knowledge from physical organic chemistry, local energetic optimizations, and experimental information. The activation barriers were converted to reaction rates and simulated with mass action kinetics. …
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Photopolymerization-based signal amplification : mechanistic characterization and practical implementation
… examining the effects of non-ideal binding reactions and oxygen. One of the greatest barriers to wider implementation of polymerization-based signal amplification is the susceptibility of radical polymerization reactions to oxygen inhibition. Oxygen reacts with initiating and propagating …
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Characterizing the anti-angiogenic resistance potential of cross-family PDGF:VEGFR2 interactions in glioblastoma
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01