Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"marmoset"”.
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String-Pulling by the Common Marmoset
… investigate skilled motor control in the common marmoset (Callithrix jacchus). In the first study, we analyzed 15 marmosets of varying ages in their home cages using single-camera markerless motion tracking. In the second study, we analyzed 6 chair-restrained adults using multi-camera 3D …
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Internalisation of the type II gonadotropin-releasing hormone receptor of marmoset monkey
The mammalian type II GnRH receptor has a C-terminal tail unlike the mammalian type I GnRH receptor, which uniquely lacks the cytoptasmic C- terminal domain. lnternalisation of a mammalian type ll GnRH receptor has never been investigated, therefore this thesis studies the internalisation pathway …
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A Behavioral Study on the Adult Marmoset Interference Control in Spatial Working Memory
… with neurodevelopmental disorders. The common marmoset (Callithrix jacchus) is an ideal non-human animal model for studying WM disorders. Previous studies of marmoset WM have used a touch-screen self-ordered sequencing task (SOST), which resembles an n-back paradigm and targets updating …
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Modelling the Neuropsychopharmacology of Obsessive-Compulsive Disorder in the Common Marmoset (Callithrix jacchus)
… either the ventromedial caudate or the putamen. Marmosets were trained on a serial reversal task that allowed multiple acute neural manipulations, and the ventromedial caudate and putamen were then reversibly inactivated using the GABAA agonist muscimol. Results indicated dose-related impairments …
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Computed tomography of the thorax and abdomen of the clinically normal common marmoset (Callithrix jacchus)
… anatomy in the clinically normal common marmoset; 2) to describe the normal reference range of Hounsfield units (HU) of major abdominal and thoracic organs; 3) to refine the computed tomography (CT) protocol; 4) to compare abdominal CT to other imaging modalities such as radiography and …
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Studies of immune biology of the common marmoset: a novel non-human primate transplant model.
… models before clinical trials. The common marmoset is a small, New World primate which our group is developing as a novel transplant model. The scope of this thesis involves the development of methodology and characterisation of critical aspects of marmoset immune biology pertinent to …
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Characterising trait anxiety in the common marmoset (Callithrix jacchus): investigations into behavioural, psychophysiological and cognitive phenotypes
… anxiety, using a new world monkey, the common marmoset. The first step was to identify animals high or low in trait anxiety. Based on the findings that high trait-anxious individuals display over-generalization of fear responses, a pathogenic marker of elevated trait anxiety in humans, a new …
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Trophoblast specification and differentiation potential in early human and non-human primate embryogenesis
… examines trophoblast development in the common marmoset (Callithrix jacchus) to investigate the molecular regulation of (1) trophoblast specification and (2) trophoblast differentiation, and ultimately the conservation of these processes in human. To delineate the molecular framework of marmoset …
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Differential contributions of subregions of the dorsal anterior cingulate cortex to negative emotion in the common marmoset
… correlates of negative emotion in the common marmoset (Callithrix jacchus). These dACC subregions were targeted with indwelling cannulae to enable pharmacological manipulations to be carried out in a range of tasks, used to assess distinct components of negative emotion, such as conditioned …
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The role of ventrolateral prefrontal cortex in performance of spatial self-ordered response sequences in the marmoset
… of specific pharmacologic agents in the common marmoset. Following a description of the necessary methodology, including behavioural training and surgical details (Chapter 2), a causal role for vlPFC in performance of spatial-self ordered sequences was confirmed in Chapter 3 by demonstrating …
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Pluripotency and patterning in nonhuman primate embryogenesis
… of pluripotency. This thesis examines common marmoset (Callithrix jacchus) development to explore the molecular cues that govern (1) naïve pluripotency in the preimplantation epiblast, and (2) primed pluripotency in the embryonic disc (EmDisc) in the context of anterior-posterior axis …
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Finding Common Ground: The Common Marmoset as a Model to Accessing and Providing Insight into the Social Brain
<p>Utilizing the immense strengths of the common marmoset (Callithrix jacchus) as a model organism, we executed three efforts with the common goal of revealing key insights into dissecting the social brain. First, we examined the hypothesis that there is a neural, functional architecture underlying …
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Examining the role of the anterior and posterior orbitofrontal cortex in emotional regulation in the common marmoset (Callithrix jacchus)
… cortex to emotional regulation in the common marmoset (Callithrix jacchus). Past research in the lab has shown that excitotoxic lesions of the anterior orbitofrontal cortex heighten anxiety-like behaviour on the human intruder test, a paradigm testing the responses to a distal threat. The …
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Untersuchung des CFL-Phänotyps ("congenital fused labia" ) in dem Neuweltaffen Common Marmoset (Callithrix jacchus) unter demographischen, physiologischen und zytogenetischen Gesichtspunkten
Die vorliegende Dissertation befasst sich mit dem Phänotyp der verschlossenen Vulva (congentital fused labia; CFL-Phänotyp) in jungen und erwachsenen weiblichen Weißbüschelaffen. Beim CFL-Phänotyp handelt es um einen Verschluss der beiden Labia majora durch ein bindegewebiges Häutchen in …
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Transcriptomic Signatures of Projection Class Neurons for Vocal Control
… reference genome assembly for the common marmoset, anon-human primate that displays flexible vocal communication abilities in complex social settings as well as rudimentary neural circuits for vocal motor control. My findings demonstrate the power of using a trio-binning approach, in …
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A Translational Approach to Modeling Unique Aspects of Germ Cell Development During Self-Organization of the Primate Embryo
… upstream of BLIMP1. Finally, we propose the marmoset as a good model of primate reproduction and embryogenesis, in an attempt to describe a non-human primate (NHP) system for validation of hPGC characteristics observed in vitro. We systematically investigate marmoset embryonic development in …
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Marmoset emotional regulation during adolescence and adulthood, with a particular focus on risk-taking and the role of the subgenual anterior cingulate cortex in motivation and affective biases
… models. During my PhD, I have used the common marmoset (Callithrix jacchus) to investigate how exploratory behaviour changes during adolescence, as well as the role of sgACC in behaviours that are impaired in depression, specifically motivation in adolescents and adults and generation of …
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Characterization of TSPO expression and radioligand-binding in the central nervous system and peripheral blood in neuroinflammatory disease
… autoimmune encephalomyelitis (EAE) in the common marmoset is a well-established primate model of MS, TSPO expression in this model has not yet been studied. Moreover, the comparison of TSPO expression and PET radioligand signal in inflammatory conditions has been limited by the lack of suitable …
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