Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"marginal zone"”.
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Alternations in the Splenic Marginal Zone with Age
<p>Splenic marginal zones are architecturally organized to generate a rapid response against blood- borne antigens entering the spleen. The marginal zone is a distinct anatomical micro-environment whose main components include the marginal zone macrophages, the marginal zone B cells, the marginal …
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Tectonometamorphic evolution of Medium-P granulites of the Namaqua Metamorphic Province at the Gordonia Subprovince marginal zone, southern Namibia
… the P-T-t evolution of a portion of the marginal zone between two major tectonic domains in the western NMC: the Richtersveld and Gordonia Subprovices is investigated, with the aim of resolving a P-T-t path for the peak to retrograde evolution of a major regional thrust, that will in turn …
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A geochemical and stable isotope study of some rocks from the Bandelierkop formation, southern marginal zone of the Limpopo Belt, South Africa( vol.1 Text)
The Bandelierkop Formation of the Southern Marginal Zone (SMZ) of the Limpopo Belt consists of metamorphosed ultramafic, mafic and sedimentary rocks. Metamorphic conditions indicated by the petrography of these different rock groups are consistent with upper amphibolite to granulite facies. The …
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Functional analysis of KLF2 and its lymphoma-derived mutants
Splenic marginal zone lymphoma is a low-grade B cell neoplasm, which originates from the splenic marginal zone B cells. Whole exome studies show recurrent somatic mutations in KLF2, and genes in the NOTCH2, NF-κB, BCR and TLR signalling pathways – pathways that are essential for the development and …
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Tolerance and Immunity: Opposite Outcomes of Microbial Antigen Stimulation
… apoptosis. Finally, the overall structure of the marginal zone, where CD4+CD8α- DCs normally reside, remained intact in mice treated with 5757, ruling out the hypothesis that these DCs would emigrate from the spleen because of a disrupted marginal zone.
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A geochemical study of neoproterozoic palaeo-evaporites and their possible role in metallogenesis in the Damara Belt of Namibia
… in the Duruchaus Formation in the Southern Marginal Zone (SMZ) of the Damara Belt was carried out. The lithological units that make up the evaporite sequence within the Duruchaus Formation were mapped and sampled, along with discordant quartz-dolomite plugs intruding at various levels in the …
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CATALYTIC-INDEPENDENT FUNCTIONS OF KDM6A IN B CELL MATURATION AND IMMUNE REGULATION
… the fraction and absolute number of splenic marginal zone (MZ) B cells were increased in Kdm6a-deficient mice. Self-replenishing B-1 B cells in the peritoneal cavity remained unaffected by Kdm6a deficiency. Following immunization with T-cell-dependent antigens, B-cell-specific Kdm6a mutant …
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Dividing the Preplate: Characterization of Neuronal Subpopulations in the Early Murine Cerebral Cortex
… layers, the preplate is split into an upper marginal zone and the lower subplate layer by the radial migration of projection neurons from the cortical ventricular zone. Cajal-Retzius and subplate neurons have important developmental functions in regulating radial migration and in pioneering …
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An alternative B cell development program
… are classically distinguished in the spleen: marginal zone (MZ) and follicular (FO). In addition, FO B cells are subdivided into FO I and FO II cells, based on the amount of surface IgM. MZ B cells, which surround the splenic follicles, rapidly produce IgM in response to blood-borne pathogens …
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Expression of Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR), Reelin Receptors in Development of Cerebellar Cortex
… by cajal-Retzius cells in the developing marginal zone and is required for inside-out layering of neurons in the cortical plate. Reelin binds to apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) that are members of lipoprotein receptor family, and …
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Role of Notch Signaling and GATA-3 in Establishing T-lineage Commitment and Survival in Developing Thymocytes
… generation of αβ and γδ thymocytes as well as marginal zone B-cells, while inhibiting B-lineage fate from bone marrow-derived progenitors. Similarly, conditional deletions of GATA-3 establish a profound need for this transcription factor in T-lineage specification for inducing expression of …
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The structural evolution of an ancient accretionary prism in the Damara Belt, Namibia
The Southern Marginal Zone (SMZ) of the Damara Belt, exposed in the Gaub Canyon in central Namibia, consists of fourteen lithotectonic units of high strain amphiholite facies rock with pelagic, hemi-pelagic and clastic sedimentary protoliths. These rocks are intercalated With lenses of metabasite. …
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Petrology of the Cenozoic igneous rocks of the Tinton district, Black Hills, South Dakota - Wyoming
… a central area of domed Precambrian Xstrata with marginal exposures of Paleozoic sedimentary rocks which dip radially outward on all sides. The area was intruded by Cenozoic igneous rocks that include a stock of quartz latite/quartz trachyte porphyry, an alkalic ring dike complex, lamprophyre …
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Molecular Insights of Primary Thyroid B-cell Lymphomas by Somatic Genetic and Immunogenetic Profiling
… thyroiditis and comprise largely of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (EMZL) and diffuse large B-cell lymphoma (DLBCL), followed by follicular lymphoma (FL). The Du group has previously shown that thyroid EMZL has a distinct mutation profile, characterised by …
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Casein Kinase I Transduces WNT Signals
… Finally, CKI expression dorsalized the ventral marginal zone in Xenopus, inducing markers of the Spemann organizer which is a product of Wnt signaling. We next investigated the ability of CKI inhibitors to block Wnt signaling in vivo. Two dominant negative forms of CKI and a specific …
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Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis
… of fetally/postnatally derived B1 and marginal zone B cells. It has been disputed whether FL also is important in HSC regulation. Our present findings establish that FL is not important for regulating HSC maintenance or expansion neither during fetal development or in adult steady state …
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The role of antibodies in tuberculosis
… unswitched memory B cells, and specifically the marginal zone B cells (MZB) subset, are impacted by ATB. MZB respond to capsular pathogens and could thus recognize the M.tb cell wall. MZB are found to be depleted in ATB but are not enriched at the site of disease in PLWH with pericardial TB. The …
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Structural-metamorphic imprint on part of the Namaqua mobile belt in Southwest Africa
… is separated from the lower-crustal central zone by a marginal zone across which there is a sharp increase in P and T. A continuous prograde metamorphic zonation is established which is bounded on the low-grade side by the 'hornblende in' reaction and includes with increasing grade …
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