Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"marble burying"”.
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Effects of Dextromethorphan on Neurite Outgrowth and Marble Burying Behavior
… for screening experimental OCD drugs include the marble-burying test (MBT) for compulsive behavior, in addition to the assessment of neurite outgrowth in PC12 cells. Therefore, to test the role of DM, a sigma-1 compound, glutamate NMDA antagonist, and DM metabolite-dextrorphan were used in both …
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STUDIES ON THE ACUTE AND LONG-TERM EFFECTS OF MDMA (3,4- METHYLENEDIOXYMETHAMPHETAMINE)
… acute hyperthermia. The effect of MDMA on marble burying behaviour in mice was also studied. Acute MDMA administration produced dose-dependent inhibition of marble burying but did not alter locomotor activity. Other monoamine releasing drugs produced a similar effect. A neurotoxic dose of …
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ASSESSING THE EFFECTS OF KETAMINE AND ITS ENANTIOMERS ON COMPULSIVE-LIKE AND DEPRESSIVE-LIKE BEHAVIOR
… ((2R, 6R)-HNK) using the marble burying test, a model to assess anti-compulsive effects of drugs, and the novel suppressed feeding test, a model to assess the antidepressant-like effects of drugs. Further, tests were conducted 0.5 and 72 hours after administration to assess …
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EFFECTS OF SIGMA-1 RECEPTOR AGONISTS ON COMPULSIVE BEHAVIOR AND NEUROPLASTICITY
… for obsessive compulsive disorder, the marble burying test, and depression, the novelty suppressed feeding test. Further, a Western blot assessment was conducted with dextromethorphan, which is a compound that exhibits all three pharmacological actions of interest for this study. The …
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The effects of chronic intermittent ethanol exposure on withdrawal related behaviors, dopamine terminal function and kappa opioid system sensitivity in the nucleus accumbens core
… ethanol drinking and anxiety/compulsive-like marble burying compared to air-exposed mice, phenotypes that were reduced by KOR blockade and replicated with KOR activation. Neurobiological examination of accumbal dopamine transmission with fast scan cyclic voltammetry in brain slices showed …
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Characterization and Treatment of A Novel Mouse Model of Tsc-Associated Autism
… increased repetitive behavior as assessed with marble burying activity. Altogether, these results demonstrate that loss of <em>Tsc2</em> in Purkinje cells in a haploinsufficient background lead to behavioral deficits that are characteristic of human autism. Therefore, Purkinje cells loss and/or …