Global ETD Search
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Showing 1 to 20 of 66 for “"mansoni"”.
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Carbon Dioxide Fixation in Schistosoma Mansoni
<p>Adults of the blood fluke <em>Schistosoma mansoni</em> were perfused from the hepatic portal system of CF1 female mice sixty to seventy days post infection. The worms were then incubated in Eagle’s minimal essential medium with glutamate and 0.03 mg/100 ml of nonlabelled aspartic acid. To this …
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The penetration protease of the cercariae of Schistosoma mansoni
… released by the cercariae of Schistosoma mansoni while penetrating mammalian skin. The proteases present in secretions collected from the preacetabular glands of cercariae were shown to be active against ¹²⁵I-labelled fibrin but not against undenatured ³H-collagen. A sensitive solid phase …
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Concurrent Infections of SCHISTOSOMA MANSONI and TRYPANOSOMA EQUIPERDUM in Mice
… on mice infected with <em>Schistosoma mansoni</em>.</p> <p>In order to maintain experimentally obtained standard hours of survival (88 hrs) in mice inoculated intraperitoneally with 150,000 <em>T. equiperdum</em>, it was found that trypanosomes removed from the donor rat should be kept …
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Avaliação da atividade anti-Schistosoma mansoni de novos ftalimido-tiazóis
… na forma adulta e forma larval do Schistosoma mansoni é necessária e urgente. Com o objetivo de identificar novos compostos protótipos que possuam atividade esquistossomicida, a atividade anti- S. mansoni de 9 compostos heterocíclicos classificados como ftalimido-tiazol foi testada e analisada. …
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Functional Studies of Stem Cells in the Parasitic Flatworm Schistosoma mansoni
Schistosomes are parasitic flatworms that infect over 200 million people, primarily in poverty-stricken developing countries, causing extensive morbidity and mortality. Schistosomes have a great deal in common with other parasitic flatworms such as liver flukes and tapeworms. Namely, they are …
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A Nonribosomal Peptide Pheromone Controls Male-Induced Female Sexual Development in Schistosoma mansoni
… of the enzyme by GLI1. Virgin female Schistosoma mansoni can sexually develop and eventually lay eggs by being soaked in BATT supplemented media. This result is pioneering in understanding the schistosome female-male interplay and provides novel therapeutic targets directly related to …
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Some Aspects of Carbohydrate Metabolism in the Cercariae of SCHISTOSOMA MANSONI Sambon, 1907
<p>Cercariac of <em>Schistosoma mansoni</em> were studied for glycogen utilization, uptake of glucose from solution, lactic acid production, and respiration.</p> <p>Using the anthrone method of determination of carbohydrate, the amount of glycogen used by a single cercaria in 4 hours is determined …
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Transcriptome characterisation of the intra-mammalian stage of male and female Schistosoma mansoni
Schistosoma mansoni is a member of a genus of platyhelminths whose members cause the disease schistosomiasis. Particularly prevalent in sub-Saharan Africa, it is thought to be directly responsible for approximately 5500 deaths per year, as well as contributing significantly to morbidity, being …
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Concurrent Infection of TRYPANOSOMA MUSCULI Kendell, 1906, and SCHISTOSOMA MANSONI Sambon, 1907 in Mice
… possible effects of ablastin on <em>Schistosoma mansoni</em> were investigated by (1) establishing a concurrent infection of <em>Trypanosoma musculi</em> and <em>Schistosoma mansoni</em> in mice, and (2) by obtaining <em>Trypanosoma lewisi</em> immune rat serum (ablastin) and injecting it into …
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The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation
Schistosoma mansoni egg passage through intestinal tissue into the faecal stream is a critical event for completion of the life cycle of the helminth and involves induction of a type 2 immune response, which is necessary for the host’s survival. Where as T cell-specific IL-4Rα has been shown not to …
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Patterns of Gene Expression in Schistosoma mansoni larvae associated with Infection of the Mammalian Host
… using the first genome-wide microarray for S. mansoni for transcriptional profiling of the three stages. The known repertoire of molecules likely to be secreted during host entry was greatly expanded, particularly the proteases and venom allergen-like proteins. Genes involved in energy …
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Avaliação da atividade do complexo de inclusão da βlapachona em ciclodextrina frente ao Schistosoma mansoni
… em 2-O-metil-β-ciclodextrina (MβCD) sobre o S. mansoni (modelo murino). Os camundongos foram infectados com 50 cercarias (cepa BH), posteriormente tratados com β-lap:MβCD por via oral com 50 mg/kg/dia ou 100mg/kg/dia por 5 dias consecutivos, iniciando-se a terapia no 1° (esquistossômulo de …
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Mobile genetic element contribution to the genome architecture of the human parasitic flatworm Schistosoma mansoni
… of the Schistosoma genus, with Schistosoma mansoni being the best characterised species and responsible for a significant proportion of deaths. S. mansoni has a complex life cycle involving two free living aquatic stages, a definitive human host and intermediate snail host. Its genome is …
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STK25 and TAO Regulate Muscle-Specific Transcription and Muscle Function in the Parasitic Flatworm Schistosoma Mansoni
… a large-scale RNAi screen in adult Schistosoma mansoni, and discovered 3 genes that produce an identical type of sickness in the worm. Disruption of the genes thousand-and-one kinase (TAO), serine threonine kinase 25 (STK25), or cerebral cavernous malformations 3 (CCM3) by RNAi in these worms …
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Structural Determination of the novel Universal Stress Protein G4LZI3 from Shistosoma mansoni using X-ray Crystallography
… Universal Stress Protein G4LZI3 from Schistosoma mansoni using X-ray Crystallography Priscilla Masamba PhD (Biochemistry) thesis, Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand Schistosoma mansoni is a parasitic multicellular helminth of the …
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Structural Characterization of the Switch domain regions of Schistosoma mansoni druggable Adenylate cyclase-stimulating Gα-protein
… development and adult productivity. Schistosoma mansoni one of the two main widely distributed causative species parasitizing human, is believed to be responsible for over 90 % of all human schistosomiasis. In the last three decades, praziquantel (PZQ) remains the first-line drug for the …
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Human antibody-mediated immunity against infection and parasite fecundity in Schistosoma mansoni and Schistosoma haematobium infection
… field data, into an age- and sex-structured S. mansoni transmission model. However, the inferior model fit for males from one tribal group highlights the need to capture heterogeneity in antibody responses that occur with varying cumulative exposure of different demographic groups. The …
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