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Showing 1 to 3 of 3 for “"mannuronic acid"”.
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Chemical Modification of Alginates in Organic Media
… linked linear copolysaccharides composed of B-D-mannuronic acid (M) and its C-5 epimer, a-L-guluronic acid (G). Several strategies to synthesize organically modified alginate derivatives have been reported, but almost all chemistries are performed in either aqueous or aqueous-organic media. The …
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Modified alginates as a matrix for gene transfection in a HeLa cell model
… were developed by chemically modifying alginic acid. Alginic acid is a linear co-polymer consisting of ~-(1-4)-D-mannuronic acid and a- (1-4)-L-guluronic acid. The carbodiimide coupling method was used to couple aromatic amines to the carboxylic acid functional groups on the alginate backbone, …
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Kationische Copolymere für den rezeptorvermittelten Gentransfer
Ziel dieser Arbeit war die Entwicklung neuer Substanzen für die Gentherapie. Diese beinhaltet die Behebung von erblich bedingten Krankheiten wie z.B. Mucoviscidose. Dabei werden im Zellkern defekte Gene durch normale, gesunde DNA-Sequenzen ersetzt. Zur Einschleusung des Genmaterials in die Zellen …