Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"mannose receptor"”.
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UNVEILING THE ROLE OF THE MANNOSE RECEPTOR IN CARDIOMETABOLIC DISEASES
OBIETTIVO: Le malattie cardiometaboliche sono caratterizzate da uno stato di infiammazione sistemica che contribuisce attivamente alla patogenesi, per cui lo studio di modulatori dell'attivazione immunitaria potrebbe offrire nuovi bersagli terapeutici. Il recettore del mannosio (Mrc1) è un …
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Role of Vitamin-D3 and Retinoic Acid In A Human Thp-1 Macrophage Model of Mycobacterium Tuberculosis Infection
… of these vitamins (RAVD) enhanced the receptors on THP-1 macrophage (Mannose receptor and DC-SIGN) that increased mycobacterial uptake but inhibited the<br />subsequent intracellular growth of Mtb by inducing reactive oxygen species (ROS) and autophagy. RAVD also enhanced antigen …
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Binding of Mycobacterium tuberculosis to complement receptor type 3 expressed in mammalian cells : dependence on serum opsonins
… the lung. M. tb. binds to a variety of phagocyte receptors, of which the mannose receptor and the complement receptor type 3 (CR3) may support nonopsonic binding. CR3, a β₂ integrin, is a target for diverse intracellular pathogens, but its role in nonopsonic binding remains uncertain. We have …
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Delivery and stability of antisense oligonucleotide conjugates in vitro
… conjugate aimed to improve uptake of ODNs via mannose receptor mediated delivery, the second investigated the improved delivery of ODN conjugates via non-specific lipophilic interaction with the cell membrane. A mono-mannose phosphoramidite derivative was designed and synthesised and a …
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The Interactions of Clostridium Perfringens With Phagocytic Cells
… Using a variety of inhibitors of specific receptors, we identified those used by J774-33 cells to phagocytose C. perfringens. The scavenger receptor, mannose receptor(s), and complement receptor (CR3) were involved in the phagocytosis of C. perfringens. To determine if PFO or PLC were …
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Glycan polymeric prodrugs against pulmonary intracellular alveolar infections
… active drug. We hypothesized that engineering mannose glycopolymer prodrugs to target the macrophage mannose receptor on alveolar macrophage cells would eradicate or minimize bacterial replication and allow for better protection against intracellular infections. We demonstrated that mannose …
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Cationic, α-helical polypeptides for cell penetration and non-viral gene delivery
… the active targeting to the cells via the mannose-receptor mediated targeting, and the membrane active polypeptide, which could penetrate the cell membrane and allow the efficient gene delivery. Then, I use the chemical modification method to modify the polypeptides with the hydrophobic …
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Investigating the susceptibility of foreskin myeloid cells to ex vivo HIV infection
… HLA-DR+CD80/86+ for maturation, and the mannose receptor, DC-SIGN and Siglec-1 as HIV attachment factors and (iii) Investigating the HIV susceptibility of foreskin epidermal cells using an optimised ex vivo pluricellular foreskin infection model of suspension cells. Methodology: Foreskin …
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Phagosome proteomes in activated macrophages
… a large number of proteins including important receptors such as mannose receptor 1 and Siglec-1. Moreover, BMDM phagosomes mature considerably faster when validated using fluorogenic phagosome function assays. <br/>For the main goal of my project, I have performed a thorough proteomics analysis …
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The effects of ES-62 on DC maturation and effector function
… cells in the body. They express a variety of receptors, including pattern recognition receptors, such as Toll–like receptors (TLRs), C-type lectin receptors (CLRs) and also receptors belonging to the Mannose Receptor group. Furthermore, DCs also express the platelet activating factor receptor …
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Targeting macrophages GLP-1 receptor pathways as emerging therapies to ameliorate cardiac remodelling associated with diabetes
… target macrophages. As macrophages express the mannose receptor, we hypothesised that addition of mannose to GLP-1 peptides would increase macrophage selectivity, promoting high affinity binding to the cell surface. However, addition of mannose was found to reduce exendin-4-GLP-1R binding and …
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Characterisation of dysregulated proteins in macrophages infected with Mycobacterium smegmatis focusing on matrix metalloproteases and their effectors
… treated and non-treated macrophages. The C-type mannose receptor 2 (MRC2) and C-type lectin domain family 11 (CLEC11A) were only expressed by the LAM-treated macrophages and may partake in the recognition and uptake of M. tb. Interestingly, the data indicates the presence of chromatin in the …
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Synthesis of mannosylated peptides as components for synthetic vaccines
… of this research was to synthesise ligands for mannose receptors (MRs) that are found on human Antigen Presenting Cells (APCs), for use in synthetic vaccines. Carbohydrate bearing antigens are recognised by MRs which play an important role in binding antigens, migration of dendritic cells (DCs) …
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Synthesis of Novel Antimycobacterials and a Fluorescent Sensor for Simple Carbohydrates
… the synthesis of antimycobacterial compounds. A mannose containing tetrasaccharide from the mannan core of lipoarabinomannan (LAM) of Mycobacterium tuberculosis has been synthesized using α-D-methylmannopyranoside as starting material and Koeings-Knorr reactions to couple saccharides. The …
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Investigating the Anti-inflammatory Activity of Honey
… that these were glycoproteins with a high mannose content by using a ConA lectin column. Next a mode of action for the glycoproteins was investigated. It was demonstrated by using mannan that honey was acting on a mannose-binding phagocytic receptor on the cell surface of macrophages, most …
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Potential Modifications to Enzyme Replacement Therapy in Anderson-Fabry Disease
… of αGal to the very high uptake scavenger receptor (SR) for improved transport to the lysosome.</p>
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Imaging Post-Infarct Myocardial Inflammation with ⁶⁸Ga-DOTATATE PET/MRI and insights into COVID-19 associated myocardial injury
… radiotracer with high affinity for somatostatin receptor subtype 2 (SST2), which has been shown to be up-regulated in pro-inflammatory macrophages. Aims: To investigate the role of hybrid <sup>68</sup>Ga-DOTATATE PET/MRI for tracking post-infarct myocardial inflammation and predicting adverse …