Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"mannose 6-phosphate"”.
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"Isozyme variation in ""helminthosporium-type"" species pathogenic on maize"
… (EC 2.6.1.1), fumarase (EC 4.2.1.2), glucose-6-phosphate dehydrogenase (EC 1.1.1.49), and mannose-6-phosphate isomerase (EC 5.3.1.8). Associated electrophoretic and virulence phenotypes were found, indicating that populations exist in S. turcica as asexually propagated clonal groups. Use of the …
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Studien zur kontrollierten Freisetzung biologisch aktiver Substanzen aus resorbierbaren Nano- und Mikrosphären
… their drug release behaviour. By immobilizing of mannose-6-phosphate entities on the surface of resorbable nanospheres, a drug targeting system for plasmids was developed by receptor-induced endocyosis. Commercially available poly(D,L-lactide) (RESOMER R 208) and poly(D,L-lactide-co-glycolide) …
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Gentechnische Modifikationen der Arylsulfatase B zur Entwicklung von Therapien für das Maroteaux-Lamy-Syndrom
… der Arylsulfatase B (ASB). Die ASB wird über Mannose-6-Phosphate an den Oligosaccharidketten ins Lysosom sortiert. Die humane ASB (huASB) hat sechs potentielle Glykosylierungsstellen. Es konnte bisher weder gezeigt werden, ob diese sechs Glykosylierungsstellen wirklich glykosyliert sind, noch …
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Investigation of the effects of Mechanical Strain in Human Tenocytes
… inhibitors of TGFβRI, metalloproteinases, RGD, Mannose-6-phosphate, integrin β1 and a thrombospondin as appropriate. qRT-PCR and a cell based luciferase assay were used to assess RNA and TGFβ activity respectively. The prolonged application of 5% cyclic mechanical strain in a 3D culture system …
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Lysosome biogenesis during osteoclastogenesis
… biogenesis. The selective phosphorylation of mannose residues on lysosomal enzymes, in conjunction with specific receptors for the mannose-6-phosphate recognition marker, has been found to be largely responsible for the targeting of newly synthesized lysosomal enzymes to lyzosomes. It is known …
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Protein quality control in the mammalian endoplasmic reticulum
… glycoproteins to the dislocation complex. The mannose-6- phosphate homology domain of OS9 is involved in the recognition of glycans on the misfolded protein. UBXD8 recruits p97, the AAA+ ATPase responsible for membrane extraction of dislocated proteins, to the ER using its UBX domain. UBC6e is …
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Molekulares Targeting von Hepatischen Sternzellen zur Therapie der Leberfibrose
… acid) (PLGA) nanospheres with mannose 6 phosphate (M6P) ligands as a specific delivery-system for activated HSC in cooperation with the Department of Textile Chemistry and Macromolecular Chemistry of RWTH Aachen. It was shown, that in vivo systemically applicated nanospheres …
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Proteomic analysis of the sorting machineries involved in vesicular traffic between the biosynthetic and endosomal compartments
… sorted along the AP-1A regulated pathway are mannose 6-phosphate receptors (MPRs) (Ghosh et al., 2003) or the gpI envelop glycoprotein of the Vesicular Zoster virus (Alconada et al., 1996), while sorting of lysosomal membrane proteins like Lamp-1 and LimpII is AP-3 regulated (Eskelinen et al., …