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Showing 1 to 20 of 23 for “"mannich reaction"”.
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A study of the mannich reaction with certain phenols, of the causes of formation of coloured products and the prevention of their occurence
Mannich bases from dimethylamine, formaldehyde and phenol, m-cresol, eugenol, p-tent-pentylphenol, p-tert butylphenol, p-iso-propylphenol, 3,1,5-trimetbylphenol, resorcinol, 3-pentadecylphenol and the component phenols of cashew nut shell liquid (CNSL) have been prepared. Mannich bases have also …
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Synthesis of pyrazoline derivatives and an examination of their local anaesthetic activity
… m-p-dialkoxy benzylidene acetones, utilising the Mannich reaction, a series of unsaturated alkyl amino ketones of the type (I)
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Mechanism-Guided Studies of Brønsted Acid and Base Organocatalysis
We have studied the mechanism of the reaction of N-Boc imines and acetylacetone in the presence and absence of chiral phosphoric acid catalysts. In order to gain mechanistic insight into the asymmetric Mannich reaction, a structurally homologous series of N-Boc imines and BINOL-derived phosphoric …
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THREE STUDIES OF 2-PYRIDONE PHOTOADDUCT REACTIVITY
… iii undergo efficient [4+4] photocycloaddition reactions, yielding strained tricyclic cyclooctadiene structures iv and v, with functionality at every carbon. As part of a program to develop the chemistry of these complex adducts, three studies have been conducted. Halogenation of trans iv give …
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Development of an Improved Synthesis of S-D-Ribosyl-L-Homocysteine (SRH) and Progress Toward SRH Analogs Modified at the C3 Position
… installed through use of a stereoselective anti-Mannich reaction. SRH analogues with increased steric bulk are hypothesized to act as inhibitors of LuxS – with the ultimate goal decreasing the amount of AI-2 in the environment and therefore silencing gene expression dependent on system 2 quorum …
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Advancements in the diastereoselective synthesis of acyl pyrrolidines via the tandem aza-Cope—Mannich cyclization pathway
… diastereoselective aza-Cope rearrangement— Mannich cyclization to form acyl pyrrolidines from conformationally mobile substrates. In earlier studies from our lab, Brønsted acid-catalyzed reactions to form the same acyl pyrrolidines resulted in diastereoselectivities of 8:1 <em>trans</em> to …
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DISCOVERY OF NOVEL MACROLIDE ANTIBIOTICS AND METHODOLOGY DEVELOPMENT OF N-SULFINYL METALLODIENAMINES
… wherein the bacterial cell serves as the reaction vessel and the ribosome catalyzes the formation of triazole cycloadducts by testing different combinations of azide and alkyne fragments. One of the mechanisms of resistance to macrolide antibiotics is exemplified by methylation of A2058 by …
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Molecular engineering strategies for expanding the capabilities of fluorescent zinc (II) sensors
… Installation of a functional group prior to Mannich reaction is impractical in many cases. This chapter describes the preparation of reactive ZP1 synthons for direct functionalization of biological targets containing an amine or azide, and reports applications to the synthesis of ZPI …
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Asymmetric Synthesis of 1,3-Amino Alcohols and Tropinone Derivatives From Enantiopure Sulfinimines
… using an asymmetric and intramolecular cascade reaction, allows for facile functionalization of one of the bridgehead carbons. This opens doors to novel derivatives of (-)-cocaine which can be used as potential addiction therapeutics or in new SAR studies of dopamine reuptake transporter …
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Investigation of zinc metalloneurochemistry with fluorescent sensors based on fluorescein platforms
… characterized. ZP1 is prepared in one step via a Mannich reaction, and ZP2 is obtained in a multi-step synthesis that utilizes 4',5'-fluorescein dicarboxaldehyde as a key intermediate. Both ZP sensors have excitation and emission wavelengths in the visible range (500 nm), dissociation constants …
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Organocatalytic asymmetric mannich-type reactions: an easy approach to optically active amine derivatives
… first concerns new organocatalytic protocols for Mannich-type reactions mediated by Cinchona alkaloids derivatives (Scheme I, left); the second topic, instead, regards the study of a new approach towards the enantioselective total synthesis of Aspirochlorine, a potent gliotoxin that recent studies …
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NATURAL PRODUCT INSPIRED METHODOLOGIES: ADVANCES IN DIASTEREOSELECTIVE N-SULFINYL IMINE AND TRIFLUOROPYRUVIC ACID REACTIONS
… a good understanding of the diastereoselective reaction with NSMD and NSMEs, I joined with Dr. Po-Cheng Yu to develop a highly diastereoselective domino Michael/Michael/Mannich reaction for the concise total synthesis of (+)- epiibogamine. The domino reaction enabled us to set all the …
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Single and hybrid antimalarials based on artemisinin, chloroquine and ß-lactams : synthesis, antiplasmodial activity, cytotoxicity and effect of selected artemisinin-chloroquine hybrids on the parasitic endocytosis pathway
… addition or multi-component condensation reaction. 4-Aminoquinolines were hybridized with artemisinin or 1,4-naphthoquinone derivatives; selected hybrids were further investigated for their effect on the parasitic endocytosis pathway and compared to the effect of chloroquine and …
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Some mannich reactions of hydroxyindoles
Thesis (M.S.)--Michigan State University. Dept. of Chemistry, 1966
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In silico-guided design, synthesis and antimicrobial activity of piperazine-linked 8-hydroxyquinoline-isatin hybrids
… Synthesis of the target hybrids began with the reaction of 5-chloromethyl-8-hydroxyquinoline 10 with piperazine to yield 5- (piperazin-1-ylmethyl)quinolin-8-ol 11. The Mannich reaction of unsubstituted/5- substituted isatin with 11, yielded Mannich bases 14a-c with yields ranging between 56 - …
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Novel reaction discovery with rapid high-throughput experimentation via infrared spectroscopy and enzymatic electrochemical oxidation of alcohols
… is to incorporate environmentally benign reaction design into routine and novel synthesis in order to minimize the use of toxic substances and waste while maximizing the overall efficiency of reaction processes. Both projects reported here encompass the idea of sustainability and …
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Synthesis and characterisation of novel α-functionalised phosphoryl derivatives
… with embedded pyridine was synthesised via the Mannich reaction. The protonation behaviour of this macrocycle has been followed by P and H NMR spectroscopy. The initial protonation pattern of the N-functionalised macrocycle is rather like its corresponding macrocyclic amine. The proton NMR …
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