Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"mammosphere"”.
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Notch Signaling Is Important in the Survival, Proliferation, and Self-Renewal of the Putative Breast Cancer Stem Cell Population
… different methods including side population, mammosphere formation and aldehyde dehydrogenase activity. Notch pathway activity was analyzed in CSCs derived from cell lines and primary tumors of different breast cancer phenotypes using quantitative reverse transcriptase-polymerase chain …
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Ezh2 T416 Phosphorylation Enhances Breast Cancer Tumorigenesis
… of EZH2 to increase cell migration/invasion, mammosphere formation, and <em>in vivo</em> tumor growth. Tumor growth and mammosphere formation are both mitigated with administration of CDK2 clinical trial inhibitor SNS032. Moreover, EZH2-T416 phosphorylation (pT416) correlates with poor patient …
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Characterisation of a novel bioactive complex polysaccharide from a marine invertebrate with potent anticancer and antimalarial activities
… chronic myelogenous leukaemia (K562), TNBC and mammosphere formation in breast cancer subtypes, and on malaria has been investigated in vitro using drug sustainable assays. Focusing on TNBC, the label-free quantitative proteomic approach has been used to gain overall insight into the mechanisms …
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Aminoflavone Inhibits α6-integrin and Growth of Tamoxifen Resistant Breast Cancer
… sensitive counterparts. AF effectively disrupted mammospheres enriched for TICs and reduced α6-integrin levels in tamoxifen sensitive and TamR cells. AF further inhibited α6-integrin’s pro-cancer signaling in TamR cells. Additionally, AF altered the miRNA expression profile of tamoxifen sensitive …
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Cholesterol synthesis inhibitors prevent growth and metastasis of breast cancer cells
… to be functionally significant, since mammosphere formation increases. Based on our observations, we contend that exposure of breast cancer cells to synthetic P, including MPA, leads to an enrichment of CSCs, which would likely support the development of P-accelerated tumors in vivo. An …
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ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION
… as well as in CSCs. Resveratrol also inhibited mammosphere formation which is an inherent property of CSCs. This inhibitory effect of resveratrol is accompanied by a significant reduction in lipid synthesis which is caused by the down-regulation of the FAS gene followed by up-regulation of …
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Amphiregulin (areg) And Epidermal Growth Factor (egf): Disparate In Egfr Signaling And Trafficking
… growth capacity. Additionally mammosphere forming assays and Adefluor staining analysis showed that knock-down of AREG expression did not affect the expression of stem cell 158 phenotypes. However, following AREG knock-down, SUM-149 cells demonstrated a dramatic decrease in …
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Trim28 Interacts With Ezh2 to Regulate Its Activity
… gene expression, in parallel with decreased mammosphere formation. TRIM28 regulation of EZH2 association with SWI/SNF complex might contribute to this process. Collectively these data indicate that EZH2 and TRIM28 regulate breast cancer stem cell maintenance by transcriptional regulation of …
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The Role of Tumor Suppressor Dear1 In The Acquisition of Mammary Stem/Progenitor Cell Properties
… cells (HMECs) and DCIS cells results in a mammosphere phenotype independent of the canonical TGF-β pathway, suggesting that DEAR1 regulates stem/progenitor cell properties. <em>DEAR1</em>-knockdown<em> </em>(KD) HMEC mammospheres express high levels of stem/progenitor cell marker aldehyde …
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Gsk3B Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties and Is A Novel Drug Target For Triple-Negative Breast Cancer
… by affecting the CSC population, we employed the mammosphere assay and analyzed the CD44<sup>hi</sup>/24<sup>lo</sup> population of these cell lines. We found that GSK3β inhibitors indeed decreased the CSC properties of the mesenchymal-like cell lines, and also decreased the expression of …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
… MDA-MB-231 cell migration and invasion, and mammosphere formation. Stem cell genes, implicated in inflammatory signaling, were down-regulated in MDA-MB-231 RANK shRNA cells.</p> <p>Collectively, our findings suggest COX-2 and RANK to regulate of CSCs in IBC and TNBC potentially through …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
… MDA-MB-231 cell migration and invasion, and mammosphere formation. Stem cell genes, implicated in inflammatory signaling, were down-regulated in MDA-MB-231 RANK shRNA cells.</p> <p>Collectively, our findings suggest COX-2 and RANK to regulate of CSCs in IBC and TNBC potentially through …
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The Epithelial to Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism
… the glycolytic metabolic program, and CSC mammosphere formation. Collectively these data are in line with an analysis of patient data that demonstrated that higher <em>GLS2</em> expression is associated with better over-all survival. Lastly, we tested a novel therapeutic strategy that …
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Lmw-E Mediates Mammary Tumorigenesis By Deregulating Acinar Morphogenesis & Generating Cancer Stem Cells
… <p>CD44hi/CD24lo population, enhanced mammosphere formation, and upregulation of</p> <p>ALDH expression and enzymatic activity. Furthermore, the CD44hi/CD24lo</p> <p>population also shows positive correlation with LMW-E expression in both the tumor</p> <p>cell line model and breast …
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Targeted magnetic hyperthermia for lung cancer
… phenotype, aldehyde dehydrogenase expression, mammosphere formation and in vivo xenotransplantation, indicated that magnetic hyperthermia reduced or, in some cases, eliminated the CSC sub-population in treated cells. Magnetic hyperthermia demonstrated pleiotropic effects, inducing acute …
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Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance
… number of stem-like cells, as measured by the mammosphere assay. Two agents inhibiting the cell cycle machinery, currently undergoing clinical trials, were further evaluated. Results showed that use of these agents in ER negative cell lines increased the number of stem-like cells, whereas a …
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Analysis of lipid metabolism regulators in breast cancer cells after induction of the Epithelial to Mesenchymal Transition
The process of tumor metastasis is often enabled by the epithelial-mesenchymal transition (EMT), a key developmental program that is often activated during cancer invasion and metastasis. During the EMT process, cells undergo phenotypic changes, lose of E-cadherin expression and acquire invasive …