Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"mammary tumour"”.
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
The leading cause of cancer deaths is tumour metastasis. The formation of metastases is a complex multistep process, involving invasion of the basal membranes and connective tissue, penetration of the blood vessel walls, invasion of the host tissue, and initiation of growth at the new location. The …
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Recapitulating mammary gland development and breast cancer cell migration in vitro using 3D engineered scaffolds
The adult mammary gland is comprised of a bi-layered epithelium of luminal and myoepithelial cells surrounded by an adipocyte-rich fat pad, a highly collagenous extra-cellular matrix (ECM) and a number of other stromal and endothelial cell types. Mammary stem cells (MaSCs) reside within the …
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In vitro studies on the cellular mechanisms of resistance to cytotoxic compounds with special reference to multidrug resistance and cancer chemotherapy
… develops to natural product, lipophilic antitumour agents the resistance is also conferred to structurally and functionally unrelated compounds. This phenomenon is termed multidrug resistance (MDR). The development of MDR in vitro is associated with a host of phenotypic changes which are …
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IDENTIFICAZIONE DI NUOVI BIOMARKER E METODI ANALITICI INNOVATIVI IN PATOLOGIA CLINICA VETERINARIA
… sialic acid has α2,6 conformation in dogs with mammary tumour, and in cats the total sialic acid serum concentration is related to the immune response of cats during Coronavirus infections. 5. At last, evaluation of analytical performances of urine protein-to-creatinine ratio: it’s a commonly …
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The role of Inhibitors of Differentiation proteins ID1 and ID3 in breast cancer metastasis
… Thirdly, the requirement of Id1/3 in controlling mammary tumour growth and metastasis was determined by conditional knockdown of Id1/3 expression during tumour progression. The data gathered is the first study to identify the global transcriptional targets of Id1/3 in breast cancer as well as to …
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Use of tissue culture to investigate the effect of methylation on methylene blue cytotoxicity
… methylene blue and toluidine blue-O, against the mammary tumour cell line, EMT-6. The toxicities of the dyes and several derivatives were assayed using standard tissue culture techniques and the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-2H-tetrazolium bromide (MTT') assay. Both I-methyl methylene …
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The role of DNA damage associated microRNAs in enhancing the chemotherapeutic responses in triple negative breast cancer (TNBC)
… (TNBC) is a heterogeneous aggressive type of mammary tumour which lacks a definite tailored therapeutic approach, consequently limiting treatment options to chemotherapeutic agents. Doxorubicin has demonstrated significant efficacy in the treatment of TNBC although many patients experience …
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DENDRITIC CELLS IN A MURINE MODEL OF BREAST CANCER: FUNCTIONAL AND PHENOTYPIC EVALUATION USING NANOPARTICLES
… DCs can induce therapeutic and protective anti-tumour immune responses, both in vitro and in vivo. These results provide an evidence of the possible use of DCs as vaccines. However, the efficacy of such therapeutic vaccination was recently questioned due to the limited degree of actual tumour …
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The Membrane as a barrier or target in cancer chemotherapy
… little difference in sensitivity. The mouse mammary tumour cell line (EMT6-S) and MDR sub-line (EMT6-R) were characterised with regard to growth kinetics, susceptibility to doxorubicin and membrane lipid composition. The log phase doubling times (h) were found to be 21.8 (EMT6-S)and 25.0 …
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Development of a gene therapy approach for the treatment of human mammary carcinoma using tissue specific retroviral vectors
… important to identify and characterise tissue/tumour specific promoter/enhancer elements in and combination with retroviral vector systems. In this present study, the ProCon system was used to construct tissue specific vectors containing either the viral MMTV U3 region or the cellular WAP …