Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"mammary tumors"”.
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Ultrasonic Characterization of Three Animal Mammary Tumors From Three-Dimensional Acoustic Tissue Models
… may help identify the scattering sites. Three mammary tumors were investigated: a rat fibroadenoma, a mouse carcinoma, and a mouse sarcoma. A 3D acoustic tissue model, termed 3D impedance map (3DZM), was carefully constructed from consecutive histologic sections for each tumor. Spectral …
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Micro-analysis of adenylate cyclase and cyclic AMP-dependent protein kinase activities in human mammary tumors
… within a series of malignant and benign human mammary tumors. The methods allow for determination of enzyme activity in histologically-confirmed neoplastic areas within individual tumors which permits comparisons to be made with particle and cytosolic fractions prepared from mammary tumors. The …
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CHARACTERIZING THE ROLE OF THE CHROMATIN REMODELING COMPONENT ARID1A AS A SUPPRESSOR OF SPORADIC MAMMARY TUMORS IN MICE
… phenotype of female mice developing spontaneous mammary adenocarcinomas. In my graduate research work, I have utilized this powerful and unique mouse model to determine the genetic drivers of these sporadic mammary tumors (MTs), based on relevance to human breast cancer data available publicly. …
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Determination of permeability-surface area products of GD-DTPA and PAMAM-TU-DTPA G = 4 magnetic resonance imaging contrast agents in mammary tumors
Open Restriction set for Item 97290 on 2016-12-14T22:51:35Z with date null by astein@illinois.edu.
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Efficacy of tamoxifen and thymoquinone on tumor development, lipid peroxidation, and total antioxidant capacity in DMBA induced mammary carcinoma in female Sprague-Dawley rats
… However, TAM has been reported to induce liver tumors in several animal models due to overproduction of free radicals and lipid peroxidation. Thymoquinone (TQ), from Nigella sativa seeds, is a Middle East natural medicine and it has been used to treat a number of diseases, including cancer. The …
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The Effects of Soy and Soy Derived Components on the Growth of Estrogen -Dependent Breast Cancer Tumors
… the growth of estrogen-dependent breast cancer tumors, (2) the matrix of the food in which the isoflavone is consumed influences its activity in vivo, and (3) genistein would stimulate the growth of chemically induced mammary tumors in rats. The first study was designed to determine if dietary …
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Quantitative estimates of mechanical properties from in vivo tumors of rodent animals
… shear waves generated in spontaneous rodent mammary tumors to estimate the complex shear modulus under realistic conditions, and to assess the sensitivity for relating matrix viscoelasticity to tumor type and stage. Cylindrical, harmonic shear waves generated by a vibrating needle (50-450 Hz) …
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The growth of murine breast cancer cells in dystrophic mice
… and signaling roles, have been reported in mammary tumors of BC patients and skeletal muscles of cachectic cancer patients. However, this complex is most frequently studied for its role in Duchenne muscular dystrophy (DMD), a severe, progressive muscle wasting disease. Despite the similar …
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TUMOR PROMOTING FUNCTIONS FOR THE METABOLIC REGULATOR SIRT5
… To study the effect of Sirt5 deficiency on mammary tumorigenesis, we used MMTV-PyMT transgenic mice, a genetically engineered model in which the animals develop metastatic mammary adenocarcinoma. We tested how mammary tumor latency, multiplicity, size and histological grade are affected by …
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Design, Synthesis and Biological Properties of Fluorinated Estrogens, Progestins and Androgens, Potential Imaging Agents for Receptor-Positive Mammary and Prostate Tumors (fluorine-18)
… estrogen receptor in receptor-positive mammary tumors. The affinities of the compounds for estrogen receptor were measured using competitive radiometric binding assays and 17(alpha)-fluoromethyl estradiol (17) and 17(alpha)-fluoropropynyl estradiol (18) found to bind to this receptor …
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Identifying Tumor Vascular Permeability Heterogeneity Using Reduced Encoding Techniques
… rats with N-ethyl-N-nitrosourea (ENU) induced mammary tumors imaged with fast T1-weighted gradient echo DCE MRI following a Gd-DTPA injection, there is a window of resolutions that detects similar PS ""hot spots"" compared to those obtained from the clinical imager resolution. The top five PS …
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Trim24 Promotes Mammary Tumor Development By Upregulating Metabolic Reducing Power
… over-expresses (COE) TRIM24 protein in mammary epithelia (<em>Trim24</em><sup>COE</sup>) and develops carcinosarcoma or metaplastic mammary tumors (70% of all <em>Trim24</em><sup>COE</sup> tumors), a rare and aggressive triple-negative subtype called metaplastic TNBC in humans (MpBC). …
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Design, Synthesis and Biological Properties of Estrogen Receptor Binding Breast Tumor Localizing Agents
… and estrogen receptor containing DMBA induced mammary tumors in mature female rats by a mechanism presumably involving the estrogen receptor. The radiobrominated 11(beta)-methoxy estradiol was more effective in this respect than the corresponding des-methoxy compound, for the immature …
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ROLE OF AUTOPHAGY IN RADIOSENSITIZATION OF BREAST TUMOR CELLS
… MCF10a cells to radiation; conversely, 4T1 mouse mammary tumors were highly sensitive to pharmacological inhibition of autophagy, suggesting selective radiosensitization against cancer cell lines. The current studies are consistent with the premise that while autophagy mediates a cytoprotective …
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Cooperative Genomic Events Driving Mutant TP53-Driven DCIS Progression
<p>Ductal carcinoma in situ (DCIS) is a mammary lesion characterized by abnormal epithelial cells occurring in mammary ducts while still being confined to the luminal space. Not all DCIS becomes invasive, and no strategy currently exists in patients to stratify indolent DCIS from DCIS at risk of …
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Inhibition of progestin-induced VEGF in mammary cancer by curcumin and 2-methoxy estradiol and their potential role as anti-angiogenic & chemopreventive compounds
… of DMBA-induced progestin-accelerated mammary tumors in Sprague-Dawley rats and progestin-dependent human breast cancer xenografts in nude mice, confirming the importance of HIF-1[alpha] in progestin-dependent VEGF release from tumor cells. YC-1 also blocks progestin-induced increases …
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Defining and Targeting Epigenetic Rewiring During Tumor Progression
… chemoresistance. First, we found that recurrent tumors undergo dramatic epigenetic and transcriptional reprogramming, partially through acquisition of an epithelial-to-mesenchymal transition (EMT). EMT promoted epigenetic silencing of tumor suppressor Par-4 through a unique, bivalent histone …
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Adipose Tissue And Its Role In Modulating The Mammary Tumor Microenvironment
… ultimately leads to unfavorable outcomes. The mammary stroma is largely composed of adipose tissue, and upon the onset of mammary tumors, the residing stromal vascular cells and adipocytes possibly partake in extracellular matrix (ECM) remodeling and blood vessel recruitment. Both …
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The Role of Inflammation and Nitric Oxide Synthase 2 in Triple-Negative Breast Cancer Metastasis
… suppresses lung metastasis from primary 4T1 tumors in Balb/c mice, providing direct evidence that inhibition of NOS2 in tumor cells can suppress metastatic progression in TNBC. We used flow cytometry to immune profile the primary orthotopic 4T1 mammary tumors, confirming the presence of …
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