Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"mammary stem cells"”.
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Characterizing in vitro propagation and radiation response of murine mammary stem cells
Stem cells in breast tissue may be sensitive to known carcinogens (i.e. ionizing radiation), which impact their susceptibility to transformation. The involvement of mammary stem cells in tumorigenesis could explain the heterogeneity and molecular complexity of breast cancer. However, the …
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New technologies and methodologies for the study of human mammary epithelial differentiation and development
The mammary gland is unique among human tissues in that the bulk of its development occurs postnatally, under hormonal control. The gland consists of an epithelium that expands dramatically during puberty and pregnancy, and is the site of breast cancer initiation. Important connections between …
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Expression of Aldehyde dehydrogenase (ALDH) in the breast stem cell line D492 and relations to stem cell properties
… are enzymes expressed in both normal and cancer stem cells (CSC). CSCs are hypothesized to arise from normal stem cells and acquire a malignant phenotype through series of genetic mutations. Current therapies often fail to eradicate CSCs causing metastatic relapse. Further characterization of …
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Recapitulating mammary gland development and breast cancer cell migration in vitro using 3D engineered scaffolds
The adult mammary gland is comprised of a bi-layered epithelium of luminal and myoepithelial cells surrounded by an adipocyte-rich fat pad, a highly collagenous extra-cellular matrix (ECM) and a number of other stromal and endothelial cell types. Mammary stem cells (MaSCs) reside within the …
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Elucidation of mammary gland development: combination of novel techniques to study proliferation and stem cells
The mammary gland is a dynamic organ that undergoes many cycles of proliferation and death throughout both oestrus cycling and the gestation/lactation/involution cycle. Moreover, it is a unique tissue in that the majority of its development occurs postnatally coincident with the production of …