Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"mammary carcinoma"”.
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Compressive stress enhances coordinated migration of mammary carcinoma cells
… stress resulted in faster migration of some mammary carcinoma cell lines. Independent of multi-cellular micro-organization, compression induced migration of mammary carcinoma cells in a coordinated sheet, initiated by "leader cells" -- single cells at the leading edge of the sheet, extending …
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Investigation of the functions of Matrix Metalloproteinase-8 (MMP-8) in Mammary Carcinoma Cells
… MMP-8 induced expression of IL-8 in mammary carcinoma cells, and also the expression of a pro-inflammatory cytokine IL-6, dependent on its catalytic activity. This required NFĸB signalling and IL-6 also required Protease Activated receptor-2. This occurred following transient …
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Vitamin B6 Decreases Proliferation and DNA Synthesis in Human Mammary Carcinoma Cell Lines In Vitro
The growth of many breast cancers is stimulated by the action of the hormone estrogen. Hormonal therapy used to treat these estrogen-dependent breast cancers acts by interfering with the action of estrogen. Current treatments, such as tamoxifen, are not consistently useful due to development of …
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NEW PREDICTIVE FACTORS IDENTIFIED BY MOLECULAR STUDY IN CHEMORESISTANT HUMAN AND CANINE MAMMARY CARCINOMA CELLS
Mammary disorders in dogs occur very frequently in non-neutered and older animals. The majority of these tumors are classified as malignant and the occurrence of metastases in lymph nodes and distant organs can reach 30% of all cases. Canine mammary tumors (CMTs) share similarities with women’s …
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Opioid inhibition of the growth of the transplantable androgen-responsive (AR) Shionogi mouse mammary carcinoma (SC115)
… androgen-responsive(AR) Shionogi mouse mammary carcinoma (SC115). In addition, the effects of opioid agonists and antagonists on the growth of SC115tumor cells in primary culture were examined. The possible role of opioids in mediating the differential tumor growth rates of mice exposed …
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Development of a gene therapy approach for the treatment of human mammary carcinoma using tissue specific retroviral vectors
… a small fragment of the WAP promoter to direct mammary specific expression was shown and this raised the possibility to replace the viral promoter with the WAP NRE. The replacement of viral U3 from the 3' LTR with the cellular WAP NRE showed no effect either at the molecular level or on the …
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Dietary vitamin B6 supplementation promotes the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in Sprague Dawley rats
… on 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats. Specifically, we aimed to identify the effect of pyridoxine (PN) supplementation on tumor growth and vitamin uptake by tumor cells. To accomplish this, 50 d old female Sprague Dawley rats were gavaged with 15 mg DMBA and …
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Efficacy of tamoxifen and thymoquinone on tumor development, lipid peroxidation, and total antioxidant capacity in DMBA induced mammary carcinoma in female Sprague-Dawley rats
… (control, DMBA, TAM, TQ, and TAM+TQ) were used. Mammary tumors were induced by DMBA which was given by oral gavage to four groups: DMBA, DMBA+ TAM, DMBA+ TQ, and DMBA+ TAM & TQ. The control group received tap water only. Starting three weeks later, TAM and/or TQ were administered daily for 10 …
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Sweat gland carcinoma of the breast: a morpho-histological study
VOLUME 1: 1. Sweat Gland Carcinoma of the Breast, 1932, EDINBURGH MEDICAL JOURNAL, VOL. XXXIX., No. 7, 1932. || 2. The Menopausal Age and Mammary Carcinoma, 1932, The Lancet. EDINBURGH MEDICAL JOURNAL, Vol. XL., 1932 || 3. Carcinoma in the Mammary Lobule and its Origin, 1933, EDINBURGH MEDICAL …
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Regulation of Matrix Metallopeptidase-1 in Breast Cancer Metastasis
… Here we confirm differential MMP-1 expression in mammary carcinoma cells with varied metastatic potentials and identify a mechanism differentially regulating MMP-1. We show that MMP-1 expression is regulated by an AP-1 element in its promoter in highly metastatic MDA-MB-231 mammary carcinoma cell …
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The effects of thermally abused frying oil polar fraction on breast cancer motility and proliferation in vitro
… and investigate the impact of the TAFO-PF on mammary carcinoma cells in vitro. The typical American consumes approximately 2,000 kilocalories per day, with approximately 33% of calories derived from fat. It is estimated that Americans consume approximately 6.3% of their total calories and 19% …
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Cancer immunotherapy with Mucin-1 and cytokines
… in the induction of cytotoxic T cells. A MUCl mammary carcinoma tumour was characterised to provide a more realistic model for MUCl immunotherapy studies. However, of particular significance was the discovery that additional IL-12 included in MFP immunisations,considerably decreases tumour …
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The recruitment of stromal cells to the site of tumor formation
… cell type found within human mammary carcinomas, but not in the normal mammary gland. Myofibroblasts can enhance tumor formation by promoting angiogenesis and invasion, and we therefore sought to better understand how myofibroblasts are incorporated into breast carcinomas. By …
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Hypoxia-selective compounds for boron neutron capture therapy
… tumor lines were tested: SCCVII squamous cell carcinoma and EMT-6 murine mammary carcinoma. Both exhibited hypoxia. Finally, quantitative studies using Inductive Coupled Plasma Atomic Emission Spectrum demonstrated that the synthesized boronated nitroimidazole reaches suitable concentrations in …
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Radiobiological evaluation of new boron delivery agents for boron neutron capture therapy
… optimized for the murine SCCVII, squamous cell carcinoma to determine the chemical toxicity and relative cellular uptake of a compound. BOPP was toxic at low concentrations and comparisons between the different compounds for thermal neutron irradiations were performed with approximately 5 [mu]g …
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Molecular Characterization of Trefoil factor 1 in Gastric Carcinoma
… that an increase in the expression of TFF1 in mammary carcinoma enhances oncogenic properties, but the effector molecule(s) mediating these functions have not been identified yet. Some studies have suggested that TFF1 may be a tumour suppressor gene in gastric carcinoma. However, a few other …
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Nutrient-dependent effects of the autophagy-lysosomal inhibitor, Chloroquine, on cell death and lysosomal functionality
… in metastatic breast cancer using the 4T1 mouse mammary carcinoma model. Investigations utilised the autophagy-lysosomal inhibitor Chloroquine (CQ) since this compound is currently in clinical trials for a variety of blood and solid cancers, including breast cancer. Here, the mechanisms of CQ and …
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Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
… node involvement. Using transplantable syngeneic mammary carcinoma 4T1 model, a differential preference for using the lymphatic system as a dissemination route was observed in immunocompetent mice when compared to immunodeficient mice. Characterisation of the differences in the tumour …
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Sulforaphane Inhibits Mammary Cancer Cell Mitotic Progression and Tubulin Polymerization
… enzymes, inhibit chemically induced mammary tumors in rodents, and more recently to induce cell cycle arrest and apoptosis in colon cancer cells. Here, we provide evidence that SUL also acts as a breast cancer antiproliferative agent. The BALB/c mouse mammary carcinoma cell line F3II …
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Adhesion-GPCRs in cancer progression and metastasis
… for all adhesion-GPCRs by RT-qPCR in murine mammary carcinoma cell lines with varying metastatic abilities as well as tumor samples of different grades, I have identified several candidate genes with possible roles in breast cancer progression and metastasis. Based on these analyses and …
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