Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2793 for “"mammalian"”.
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Mammalian-wide interspersed repeats (MIRs) and their role in mammalian gene function and evolution
… or novel function for endogenous genes. Mammalian-wide interspersed repeats (MIRs) are short interspersed nuclear elements (SINEs), belonging to the non-autonomous class of retroelements and are found in all mammals. The recruitment of an MIR element by a gene may provide insight into …
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The Mechanism of Mammalian Pexophagy
The mechanism of mammalian pexophagy is poorly understood. Although ubiquitination is thought to be involved in the process, the upstream and downstream effectors of ubiquitination remain elusive. Specifically, the E3 ligase responsible for mediating ubiquitination is not known, the site(s) of …
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Acorn Contribution to Mammalian Energetics
… Conversely, the seed dispersal action of these mammalian predators is vital to the reproductive success of the oak trees. The objective of this study was to determine the significance of acorns as a food source for mammals at the Missouri State University (MSU) Bull Shoals Field Station in Taney …
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Regulation of mammalian SINE transcription
Despite the abundance of the templates, both human and rodent SINEs are normally expressed at a very low level. DNA methylation-mediated silencing has been proposed as a possible cause of their transcriptional repression. The effect of DNA methylation and the effect of DNA methylation-dependent …
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Mammalian comparative genomics and epigenomics
The human genome sequence can be thought of as an instruction manual for our species, written and rewritten over more than a billion of years of evolution. Taking a complete inventory of our genome, dissecting its genes and their functional components, and elucidating how these genes are …
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UCHLI in the Mammalian Nervous System
UCHL1, or Ubiquitin Carboxy Terminal Hydrolase L1, is a de-ubiquitinating enzyme (DUB) thought to be involved in ubiquitin recycling. Beyond this, its natural function is almost wholly unknown. Mice lacking this enzyme exhibit a severe and rapidly progressing neurodegenerative phenotype. Using one …
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Mathematical modelling of mammalian mitochondrial metabolism
… function of the cardiac muscle. The mammalian liver-specific tricarboxylic acid cycle (TCA) model developed within the Cell Systems Modelling Group (CSMG) was used to study and understand the basic functional properties of a tissue-specific TCA cycle model system and to form a …
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Bioinformatics study of mammalian MRNA polydenylation
… is one of the key post-transcriptional events in mammalian cells, which have influences on many aspects of mRNA metabolism. Several human diseases have been shown to associate with abnormal polyadenylation, highlighting the importance of this process. The availability of the complete sequence of …
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Magnesium homeostasis in the mammalian heart
… of transmembrane movement of cations. In most mammalian cells intracellular Mg2+ is kept well below electrochemical equilibrium. In cardiac muscle cells recent studies suggest that the intracellular and extracellular concentrations of Mg2+ are around I and 0.5 mIs4, respectively. The …
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Characterisation of HP1γ in mammalian cells
… as other DNA-dependent biological pathways. The mammalian HP1 (Heterochromatin protein 1) protein family consists of three members: HP1α, β and γ. Each paralogue regulates formation and maintenance of heterochromatin by binding to the repressive chromatin marks H3K9me2/3 with their chromodomains …
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Transmission at the mammalian neuromuscular junction
For more than a century vertebrate nerve-muscle preparations have been extensively investigated. This is not surprising for such preparations are readily accessible and may survive, isolated, in simple solutions for many hours. Furthermore the mechanical response of muscles to direct and indirect …
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Transmission at the mammalian neuromuscular junction
For more than a century vertebrate nerve-muscle preparations have been extensively investigated. This is not surprising for such preparations are readily accessible and may survive, isolated, in simple solutions for many hours. Furthermore the mechanical response of muscles to direct and indirect …
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Genetic Code Expansion in Mammalian Cells
… precision and minimal perturbation. Cultured mammalian cells present an attractive model for studying human biology and disease. The first aaRS/tRNA pair used for genetic code expansion in mammalian cells was the Escherichia coli (Ec) tyrosyl-tRNA synthetase (TyrRS) and Bacillus …
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Control mechanisms of mammalian pepsinogen secretion
… delineate aspects of the control mechanisms of mammalian pepsinogen secretion. In order to accomplish this goal, a comprehensive study was undertaken which would establish an historical perspective of the subject, validate appropriate methodology and then seek to answer specific questions …
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Discontinuous DNA synthesis in mammalian cells.
Thesis. 1976. Ph.D.--Massachusetts Institute of Technology. Dept. of Biology.
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Continuous Directed Evolution in Mammalian Cells
… evolved biomolecule is intended to function in mammalian cells. As a result, the functions of biomolecules evolved in these environments are often derailed in the complex mammalian cellular environment. The development of highly efficacious methods for directed evolution in mammalian cells has …
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Targeting and function of mammalian microRNAs
… extend the direct and indirect influence of mammalian microRNAs to the majority of protein-coding genes. Although seed sites account for much of the specificity of microRNA regulation, they are not always sufficient for repression, suggesting the contribution of additional specificity …
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Interrogation and control of mammalian transcription
… generalizable, and precise perturbation of mammalian gene expression. The first part of my research focused on the development of light-inducible transcriptional effectors (LITEs) to mediate positive and negative regulation of endogenous mammalian gene expression (Konermann et al. Nature …
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