Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"malignant transformation"”.
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Studies on the Mechanisms of Malignant Transformation in Neurofibromatosis Type 1
… 발생한다. 환자의 약 10%에서는 높은 사망률과 화학요법과 방사능에 낮은 반응을 보이는 malignant peripheral nerve sheath tumors(MPNSTs)로 악성화 된다고 알려져 있다. NF1은 높은 발병률, 예측불허의 다양한 합병증 동반과 악성화, 임상적 증상의 다양성과 심각성, 치료방법의 부재 등으로 인해 효과적이고 근본적인 치료법에 대한 기초적, 임상적 연구가 절실히 요구되고 있다. NF1은 정상세포에서 양성종양세포, 악성종양세포로 악성화 되는 다양한 과정은 보고 되어 있으나, 아직 정확한 악성화 기전이 …
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The role of viral sequences in genetic aberrations and malignant transformation
… genes required for the initiation of cellular transformation and also to identify genomic alterations associated with oesophageal squamous cell carcinoma. Cancer is a leading cause of death worldwide and viral infections such as HBV/HCV and HPV have been known to be responsible for up to 20% of …
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Potassium and Sodium Movements Related to Growth State and Malignant Transformation in Cultured Chicken Embryo Cells
… on the cellular growth state but unaffected by malignant transformation; potassium influx and ouabain binding values in growing normal and transformed chicken embryo fibroblasts were 1.5 to 1.8-fold greater than in density-inhibited cells. Growing normal and density-inhibited cells were found to …
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The susceptibility of primordial germ cells to malignant transformation and isolation and characterization of members of a new gene family differentially expressed in invasive and non-invasive immortalized male germ cells
… der Primordial Keimzellen (PGCs) zur malignen Transformation unter Verwendung eines transgenen Mausmodell. In diesem Modell verwendeten wir das SV40 large Tumor Antigen (LTA),welcher mit dem Keimzellen alkalische Phosphatase (GCAP) Promotor verbunden ist, um direkt die Onkogenische Aktivität …
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Metabolic regulation in Phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells
… showed that PTEN deletion in thymocytes prior to malignant transformation, resulted in a robust activation of AKT but did not cause T cells to increase glucose, glutamine or leucine uptake or activate mTORc1. In this context, we noted that PTEN-/- T cell lymphoma/leukaemia cells but not PTEN-/- …
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The pre-clinical evolution of haematological malignancies
… genetic and clinical features predictive of malignant transformation. The final part of this study investigates the prevalence of clonal haematopoiesis in childhood cancer survivors treated with intensive chemo- or radiotherapy. In contrast to adult cancer patients, the prevalence of CH in …
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The role of BCLFA1 in cellular transformation
The malignant transformation of normal cells into cancer cells result in the loss of control of cellular regulatory mechanisms such as loss of function of tumour suppressors and gain of function of oncogenes. Genetic mutations may be inherited or acquired during the process of malignant …
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UNDERSTANDING LAMIN A/C AND ITS ROLES IN DISEASE PATHOLOGIES
… OF GENES ASSOCIATED WITH HYPERPROLIFERATION AND MALIGNANT TRANSFORMATION. THESE RESULTS INDICATE THAT A-TYPE LAMINS REGULATE CELL PROLIFERATION. USING LMNA AND LAMIN B RECEPTOR (LBR) KNOCKOUT MICE, WE SHOW ABSENCE OF BOTH PROTEINS RESULTS IN THE DISPLACEMENT OF PERIPHERAL HETEROCHROMATIN. LOSS OF …
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Development of Electrochemical Immunosensor for Oral Cancer: Initial Outcome
… non-invasive, point-of-care screening for malignant transformation in patients with oral premalignant disorders such as OL. However, further research involving clinical samples and larger datasets is necessary to establish the sensor's diagnostic accuracy and real-world applicability.
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Studies on the Molecular Mechanisms of Tumorigenesis in Neurofibromatosis Type 1
… characterized by a high incidence of benign and malignant tumors attributed to loss of function of NF1. NF1 gene encodes neurofibromin, a tumor suppressor with Ras-GAP activity that negatively regulates p21-RAS signaling. Neurofibromin deficiency typically causes chronic activation of Ras, which …
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Investigation of Ring Finger Protein 8 in Mammalian Physiology and Pathogenesis
… is often viewed as a cellular shield against malignant transformation, DNA double-strand breaks (DSBs) are probably the most dangerous threat to the maintenance of a stable cellular genome. Mammalian cells have evolved a sophisticated DNA damage response (DDR) network that senses the physical …
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LKB1, CCL2, and Macrophages: A New Axis of Endometrial Cancer Progression
… However, the mechanism(s) by which LKB1 drives malignant transformation of uterine cancers remains unclear. Here I show that LKB1 unexpectedly suppresses tumor progression via pAMPK dependent secretion of the inflammatory cytokine CCL2. Lkb1 inactivation in vivo resulted in abnormal production …
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The use of conventional and advanced magnetic resonance techniques in the assessment of primary brain tumours
… cohort, as patients were treatment free until malignant transformation was diagnosed, which translates the natural history of these brain tumours. It is unlikely to find such a specific cohort as most of the patients receive treatment after the initial diagnosis of low grade gliomas. Chapters 1 …
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Investigating the Fate of Pre-neoplastic Cells in a Mouse Model of Medulloblastoma
… a transition during which normal cells undergo malignant transformation. However, the link between the pre-neoplastic cells and end-stage disease has never been formally established. To investigate the fate of such cells, the patched (ptc) mutant mouse, a model for the brain tumor …
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The Role of LKBI Tumor Suppressor in Endometrial Cancer
… endometrial LKB1 inactivation developed diffuse malignant transformation of their entire endometrium with rapid extrauterine spread and death, by 7 months, suggesting that LKB1 inactivation was sufficient to promote the development of invasive endometrial cancer. This much improved model also …
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Characterization of The Role(S) of Env Protein of Human Endogenous Retrovirus-K In Multiple Human Cancers
… of HERV-K in melanoma cells correlates with malignant transformation, while a serological response to HERV-K in breast cancer or melanoma patients correlates with survival probability. However, the mechanism behind these observations remains obscure. Our laboratory reported that anti-HERV-K …
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Novel Role of CHK2 in the Intrinsic and Extrinsic Apoptosis Pathway
… fidelity, promote cell survival, and prevent malignant transformation. Checkpoint kinase 2 (CHK2) is an evolutionarily conserved serine/threonine protein kinase that is activated in response to DNA double strand breaks. Upon activation by the DNA damage transducer kinase, ATM, CHK2 …
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An in vitro cell lineage model to identify alterations in the differentiation program of neuroblastoma
… oncogenic insults can occur leading to the malignant transformation giving origin to neuroblastoma. The precise steps along the differentiation path in which the tumorigenic alterations bring to a differentiation block is still unclear. In the attempt to elucidate this point, we successfully …
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Resection of biliary mucinous cystic neoplasms: Study of a single institutional cohort and a literature review
… incorrectly diagnosed and have the potential for malignant transformation. Aim: The aim of this study was to assess the outcome of surgical resection of BMCNs. Methods: Data from a departmental and faculty registered prospective liver surgery database was used to identify patients who underwent …
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TARGETING CANCER METABOLISM WITH FASTING-MIMICKING DIET¿BASED LOW-TOXIC COMBINATION THERAPIES: OVERCOMING RESISTANCE THROUGH METABOLIC SYNERGY
… sensing, and chronic inflammation promoting malignant transformation. Among age-associated cancers, non-small cell lung cancer (NSCLC) is the most prevalent and lethal, with KRAS mutations occurring in up to 25–30% of lung adenocarcinomas. Tumors harbouring this mutated oncogene are …
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