Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"malignant mesothelioma"”.
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The emerging roles of BAP1 and cancer stem cells in Malignant Mesothelioma
Malignant Mesothelioma (MMe) is an aggressive asbestos-related cancer with a poor prognosis and the standard treatments are not effective. The lack of successful therapies is due to several factors, including the poor knowledge of mesothelioma biology. In this thesis, several biological aspects …
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PLGA-DS reverses chemoresistance in malignant mesothelioma by targeting hypoxia induced cancer stem cells
Background: Malignant Mesothelioma (MM) is a malignancy related to asbestos exposure which causes a wide variety of molecular aberrations. MM has a very dismal treatment outcome with an overall survival of fewer than 12 months, with less than five drugs available for its treatment. MM recurrence is …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
<p>The highly aggressive cancer, malignant mesothelioma, responds poorly to available treatment options. As most individuals diagnosed with these tumors succumb to the disease within about 2 years of diagnosis, it is imperative to develop a more thorough understanding of molecular mechanisms of the …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
<p>The highly aggressive cancer, malignant mesothelioma, responds poorly to available treatment options. As most individuals diagnosed with these tumors succumb to the disease within about 2 years of diagnosis, it is imperative to develop a more thorough understanding of molecular mechanisms of the …
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Involvement of the WT1 and p16 genes in Wilms' tumour and human malignant mesothelioma
Normal cellular homeostasis is established and maintained by the positive and negative regulatory activities of many genes. When these genes are mutated to forms that can contribute to tumorigenesis, either by dominant, gain of function mutations in positive regulators or recessive, loss of …
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In vitro and in vivo investigation of the anticancer activity and mechanism of disulfiram in malignant mesothelioma
Background Malignant Mesothelioma (MM) represents an asbestos-related insidious and invasive neoplasm with a long latency period. MM carries a dismal prognosis as most patients have irresectable disease or are ineligible for surgery due to medical comorbidities or old age, leaving chemotherapy and …
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ON THE USE OF ASBESTOS IN CENTRAL ASIAN COUNTRIES: FINDINGS IN POSTMORTEM LUNG SAMPLES, CHARACTERIZATION OF ASBESTOS-CONTAINING MATERIALS, ENVIRONMENTAL AND OCCUPATIONAL EXPOSURE. CASE STUDIES IN KYRGYZSTAN.
… consequences of asbestos-related diseases is malignant mesothelioma. The estimated age-standardized incidence of mesothelioma (both sexes, all ages) in Kyrgyzstan was 0,06 in 2020, 2nd lowest index among other Central Asian (CA) countries (Tajikistan 0,02; Uzbekistan 0,11; Turkmenistan 0,16; …
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LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS TO HMGB1 AND ITS REGULATED SECRETION IN LUNG CANCER
… 1 (CRM1) rather than acetylation or oxidation. Malignant mesothelioma (MM) cell lines were found to constitutively secrete unacetylated HMGB1, and the cysteine oxidation profiles in HMGB1 from cisplatin-mediated, dimethyl sulfoxide-mediated, and MM secretion were found to have statistically …
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Detection and Characterisation of Airborne Carcinogenic Erionite Fibres in New Zealand Roadside Environments Using a Novel Integrated Methodology
… is strongly linked to the development of malignant mesothelioma, one of the most aggressive cancers known. Although the geological occurrence of erionite has been reported worldwide, including in populated areas of New Zealand, its detection in the air remains extremely challenging due to …
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… lung cancer, or SCLC) and mesothelial origin (malignant mesothelioma, or MM). The DNA oncogenic virus Simian Virus 40 (SV40) has been shown to cooperate with environmental oncogenic fibers in the onset of MM. Insulin like growth factor-1 (IGF-1) signaling plays a central role in all thoracic …
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Determination of p53 role in cancer biology and therapy through interactome development and analysis
… 61 deregulated genes considered as important to mesothelioma (Meso-PMH61 model), and superimposed microarray data generated in our laboratory of mesothelioma cells treated with etoposide and 1 % O2 oxygen.We analysed all models, in silico, using CellNetAnalyzer. In silico knockout analysis of …