Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 465 for “"malignancy"”.
-
Periocular malignancy.
… thesis focus on the management of periocular malignancy. The most common tumours to involve the eyelids in order of frequency are: basal cell carcinoma (90%), squamous cell carcinoma (5-8%), sebaceous gland carcinoma (2-3%) and melanoma (1%). The eyelids represent a high risk area for …
-
Machine Learning Techniques for Augmenting Hematological Malignancy Diagnosis
This dissertation examines the use of modern machine learning (ML) methods to enhance the diagnostic workflow of hematological malignancies, particularly in cytogenetics and clinical flow cytometry. The recent advancements in the field of ML provide a unique opportunity to develop, adapt, and …
-
Lung cancer malignancy predication with recurrent neural networks
… baseline results on the benchmark task of malignancy prediction using this time-series data. We analyze the use of longitudinal models to capture the progression of nodule malignancy and see that recurrent neural networks (RNNs) outperform standard CNNs by 4.58% in accuracy, 5.03% in …
-
Aspects of The Preoperative Pathway in Pancreatic Head Malignancy
Malignancy within the pancreatic head can arise from pancreatic duct, distal bile duct, ampulla or duodenum. Since September 2000, surgery for all pancreatic head malignancy (PHM) has been centralised into regional pancreatic centres where assessment of preoperative imaging and subsequent surgery …
-
Ras Drives Malignancy Through Stem Cell Crosstalk with the Microenvironment
… progression from benign papilloma to invasive malignancy. A subset of tumor-initiating basal progenitors, the cancer stem cells, obtain increased resistance to chemo and immunotherapy along this path. However, the distribution and changes in cancer stem cells during progression from a benign …
-
Predicting risk of malignancy in patients with indeterminate thyroid nodules
… are surgically removed in order to rule out malignancy after indeterminate FNA results. Our goal is to identify clinical and ultrasound predictors of benign results in indeterminate nodules, to assist physicians in selecting nodules for surgical removal versus monitoring with ultrasound …
-
Assessing Patient Attitudes to ward Genetic Testing For Hereditary Hematologic Malignancy
… to predispose to hereditary hematologic malignancy (HHM). Although the diagnostic yield of germline analysis for leukemia is similar to solid tumors, referral for genetic evaluation in adults with leukemia is underperformed. Identifying HHM is important for prognostication, treatment, and …
-
Senescence Associated Secretory Phenotype Regulation in Lung Aging and Malignancy Progression
… of lung aging and the progression of lung malignancy.</p>
-
Co-optation of B Cell Developmental States in Malignancy and Autoimmunity
… heterogeneous B cell developmental states in malignancy and autoimmunity, and uncover underlying signaling perturbations linked to their dysfunctional transcriptional regulation. We consider how these aberrant developmental states are driven by mutational perturbations to dysregulated …
-
Bronchial gene expression associated with airway pre-malignancy and lung cancer subtypes
Lung cancer is one of the most aggressive cancers and the leading cause of cancer mortality in the US, mainly due to the lack of early detection. Meanwhile, gene expression profiling can identify molecular responses to carcinogen exposure and tumorigenesis. We have previously identified lung …
-
An Explanatory Model on Quality of Life in Patients with Hematologic Malignancy
본 연구는 혈액암 환자의 삶의 질을 설명하는 요인을 규명하고 요인들 간의 영향력을 확인하여 설명모형을 제안함으로서 혈액암 환자의 삶의 질을 예측하는 요인을 제시하고자 시도되었다. 본 연구의 가설적 모형 구축을 위하여 Wilson과 Cleary (1995)의 건강관련 삶의 질 모델과 혈액암 환자의 삶의 질에 대한 선행연구를 분석한 결과, 자기효능감, 진단 후 기간, 사회적 지지는 외생변수로 증상, 자가간호행위, 지각된 건강상태, 삶의 질은 내생변수로 선정하였다. 자료 수집은 경기도 소재 2개 병원과 한국 혈액암 협회에서 치료 과정에 …
-
Modulating SIRP-alpha, a Myeloid-Specific Immune Checkpoint, for Immunotherapeutic Treatment of Malignancy
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
Investigating the translational and metabolic reprogramming of the bone marrow niche in myeloid malignancy
In acute myeloid leukaemia (AML), malignant cells surviving chemotherapy rely on high mRNA translation and their microenvironmental metabolic support to drive relapse. However, the role of translational reprogramming in the niche was, until now, unclear. This study found that relapsing AML cells …
-
The role of latent membrane protein 2 in the pathogenesis of Epstein-Barr virus associated malignancy
Epstein-Barr virus (EBV) establishes a lifelong latent infection in host B cells and is associated with the development of various lymphoid and epithelial malignancies. Approximately half of Hodgkin's lymphomas (HL) are EBV positive where LMP2 is highly expressed. However, the contribution of LMP2 …
-
Improving the peri-operative management of patients undergoing free tissue transfer for head and neck malignancy
Abstract The cohort of patients with oral malignancy is typically of advanced age with significant comorbidity. The causative factors for such malignancies, such as tobacco and alcohol, are also those which result in cardiovascular disease. As a result patients undergoing ablative and …
-
In vivo and ex vivo techniques using elastic scattering spectroscopy for diagnosis of malignancy in the thyroid gland
… Thyroid cancer is the most common endocrine malignancy and patients presenting with thyroid nodules often undergo surgery solely for diagnostic purposes. The goal of our study was to examine the accuracy of Elastic Scattering Spectroscopy (ESS) in distinguishing between benign and malignant …
Page 1 of 24