Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 177 for “"malfunction"”.
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Pulmonary vascular malfunction and inflammation during Orientia tsutsugamushi infection
Scrub typhus is a potentially lethal illness caused by infection with the bacterium, Orientia tsutsugamushi. Scrub typhus remains a neglected tropical disease, despite being a tremendous burden in endemic areas. Lung injury is one of the most common pathologies that arise from severe cases of scrub …
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Evaluation of Traffic Operations at Intersections in Malfunction Flash Mode
During a signal malfunction, traffic signals are operated in the flash mode. During this event, drivers are presented with one of two possible scenarios: (1) flashing yellow on the major street and flashing red on the minor street or (2) flashing red on all approaches. Yellow/red flash is typically …
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Regional Lysosomal Malfunction Underlies the Selectivity of α-Synuclein Neurodegeneration
Dysfunction of protein homoeostasis has been implicated in the pathogenesis of a diverse array of neurodegenerative disorders. However, each neurodegenerative disease is characterized by the accumulation of particular proteins in select regions of the brain. It remains unclear how dysfunction of a …
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Procollagen Biosynthesis and Osteoblast Malfunction in the G610C Mouse Model of Osteogenesis Imperfecta
… was to lay the foundation for understanding how malfunction of bone producing cells contributes to OI pathology with the aim of finding treatments that do not involve presently unrealistic gene repair. Specifically, we focused on characterizing how the most common OI mutations in collagen affect: …
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The Effects of Angle-of-Attack Indication on Aircraft Control in the Event of an Airspeed Indicator Malfunction
… aircraft control following an airspeed indicator malfunction on final approach. Participants flew a final approach with a target airspeed range of 60 to 65 knots. Once participants slowed the aircraft for final approach, the airspeed indicator needle would be stuck at an indication of 70 knots. …
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More than a Metaphor of Malfunction : Conceptualisations and Uses of Silence in the Worlds of Everyday Life and Teaching.
The word 'silence' is used in many different contexts and has been discussed from the perspective of various disciplines. This thesis compares how this complex concept is understood and embodied in the social practices of everyday life and teaching. The worlds of everyday life and the classroom are …
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Performance of re-used pacemakers and implantable cardioverter defibrillators compared with new devices at Groote Schuur Hospital, Cape Town, South Africa
… to compare the risk of infection and the rate of malfunction of re - used pacemakers and ICDs with new devices at Groote Schuur Hospital in Cape Town, South Africa. Methods: This was a retrospective case comparison study of performance of re - used pacemakers and ICDs in comparison with new …
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Parents' management of their child's hydrocephalus and shunt
… main treatment for hydrocephalus. When shunts malfunction the consequences are serious and can be life threatening. Identifying shunt malfunction requires effective parent-professional collaboration: parents need to recognise and respond appropriately to the symptoms of shunt malfunction in …
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A case study in troubleshooting electromechanical software-controlled systems : the InMotion² Robot
… preparation for the experiments, however, a malfunction was discovered in the robot. A series of systematic tests were carried out to determine what part of the robot was causing the malfunction. It was determined that the magnets on one of the two motors were slipping on the rotor shaft. …
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Reference Design of an Online Emulation and Hot-Patching Approach for Power Electronic Controller Validation
… of a malicious or accidental controller firmware malfunction. </p> <p>The online security system is embedded in a controller board consisting of three main hardware components described in this thesis: Serial Communication Interface, Digital Signal Processors, and Field Programmable Gate Array. …
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A context based data sanity checking algorithm and its implementation
… which help in identifying sensor (versus system) malfunction. Slow tracking of the relationships among the parameters as they change over time is made possible through on-line training of the neural networks on the most recent data. This helps to account for the dependency of the relationships …
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NOTCH SIGNALING REGULATES ADIPOGENESIS AND ENERGY METABOLISM
… metabolic disorders. Obesity is resulted from malfunction of the overloaded white adipocytes, which are the primary default storage sites of energy surplus. Another two types of adipocytes can also be found in human: beige and brown adipocytes. In opposite to white adipocytes, beige and brown …
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Zu Entstehungsmechanismen von Plasma Leakage in mikroporösen Kapillarmembranoxygenatoren
… transition of albumin or albumin fragments. This malfunction of oxygenators was called leakage-similar-event. In the clinical use of oxygenators, the transferred liquid was examined with urine test stripes. The amount of detected proteins was much higher than in the in-vitro or animal studies. In …
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Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
… contribute to control of neuronal excitability. Malfunction of specific Nav channel isoforms is associated with a wide range of brain disorders including psychological, neurological and developmental disorders. Unfortunately, currently available drugs targeting Nav channels are directed against …
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Design and Manufacturing of Hierarchical Multi-Functional Materials Via High Resolution additive Manufacturing
… expansion of parts or components can lead to malfunction or breakdowns of complete systems in demanding environment where a large temperature gradient often exists. This work investigates a class of lightweight materials of which the thermal expansion coefficient can be controlled. Moreover, …
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GC-MS Investigation of Metabolic Activity in 4-Hydroxy-2-Oxoglutarate Aldolase Deficiency of Primary Hyperoxaluria Type 3
… is also the least understood. PH3 is caused by a malfunction in the enzyme 4-hydroxy-2-oxoglutarate aldolase (HOGA), which catalyzes the cleavage of 4-hydroxy-2-oxoglutarate (HOG) to form glyoxylate and pyruvate. Since the enzymatic malfunction occurs before glyoxylate formation, and previous …
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MULTI-SOURCED INFORMATION TRUSTWORTHINESS ANALYSIS: APPLICATIONS AND THEORY
… various reasons such as recording errors, device malfunction, background noise and intent to manipulate the data, some other sources may contain noisy or even erroneous information. Therefore, it is inevitable that information from multiple sources is conflicting with each other. To discover …
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Some ways that a thing can go wrong : malfunctions, disorders and perversions
… the idea that a medical disorder is a harmful malfunction. "Teleological Theories of Sexual Perversion" examines attempts to analyze sexual perversion in terms of the biological goal of sex or the functions of sexual organs and psychological mechanisms. I argue that teleological theories are …
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Behavioral model based trust management design for IoT at scale
… behavior such that any device that begins to malfunction or behave maliciously can be detected and mitigated in real-time. This behavioral analysis will be further applied to supplement trust management approaches such that a more accurate value can be associated with the device's perceived …
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Genomic analysis of control of cell type
… understanding of how these cells work, how they malfunction in disease, and several general principles. This thesis describes several studies designed to understand the transcriptional regulatory circuitry of three different medically important cell types; embryonic stem cells, regulatory T cells …
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