Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"male fertility"”.
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Effects of cocaine on male fertility
… to demonstrate the adverse effects of cocaine on male fertility and to identify the mechanisms of action of cocaine on testicular function. Materials and Methods: Peripubertal male rats were given cocaine hydrochloride (15 mg./kg body weight, corresponding to an average single dose for a heavy …
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SPAG16 is a Bifunctional Gene Regulating Male Fertility
… transcript and protein are detected only in male germ cells, suggesting a unique role distinct from general axoneme formation. Transgenic mouse studies published previously by our lab have shown that abrogation of both SPAG16 isoforms causes arrest of spermatogenesis, and the mutant allele is …
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Negative biomarkers of sperm quality and male fertility
… respectively. Analysis of the results of SCSA, infertility treatment outcomes, and the occurrence of spontaneous abortions (SAB) and multiple births was conducted in 233 couples. A correlation was found between SCSA parameters and SAB, and lower levels of chromatin defects were found in men from …
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Endocrine, cellular and molecular effects of diabetes mellitus on male fertility
… As such, diabetes has the potential to affect male fertility at a number of levels. Despite this, the prevalence of reproductive disturbances in diabetic men remains largely unknown. This study was carried out to evaluate the effects of diabetes on functional, endocrine, cellular and molecular …
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Detection of the Effects of Treatment on Male Fertility by Heterospermic Insemination
Made available in DSpace on 2014-12-13T19:42:46Z (GMT). No. of bitstreams: 1 7820951.pdf: 3189674 bytes, checksum: d03edb9b5d963d859727fa41808ca0aa (MD5) Previous issue date: 1978
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In vitro maturation and fertilization of porcine oocytes and evaluation of male fertility
… techniques to determine the difference of sperm fertility from different boars. In the study of in vitro oocyte maturation, the oocyte maturation process was divided into the stages of germinal vesicle (GV I, GV II, GV III, and GV IV), metaphase I (EPromet I, LPromet I, and Met I), anaphase I …
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The Role of the Nhlh2 Protein in Regulating Male Fertility and Sexual Development
Infertility is a major problem worldwide-about one in six people will experience reproductive issues at some point in their lives. These issues can have many causes, ranging from lifestyle factors to genetic influence. There are a variety of treatments that exist, including lifestyle intervention, …
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INVESTIGATING MECHANISMS REGULATING MAMMALIAN SPERMATOGONIAL DIFFERENTIATION AND MEIOTIC INITIATION
… initiation are complex processes essential for male fertility. Despite knowing for nearly 60 years that retinoic acid (RA) is instrumental for successful production of functional sperm, molecular mediators that regulate spermatogonial differentiation and prepare male germ cells for meiosis are …
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Investigating mitochondrial dynamics in Drosophila spermatogenesis: a focused study on the mitoball
… – a complex developmental process that generates male gametes – is accompanied by substantial alterations in mitochondrial shape, quantity, and distribution. Previous studies have mainly focused on mitochondrial dynamics in post-meiotic spermatids, consequently little is known about mitochondrial …
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The human Deleted in Azoospermia gene family : structure, function and evolution
… in men with severe spermatogenic failure and male infertility. This thesis describes the evolution, structure and function of human DAZ genes. First, we determined that Y-linked DAZ genes arose by transposition from an autosomal ancestor during primate evolution, and were repeatedly amplified …
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Investigation of isoform-specific fruitless mutants generated by gene targeting in Drosophila melanogaster
… individual steps of the Drosophila melanogaster male courtship ritual. Much of the transcriptional differentiation is achieved through the use of multiple promoters, sex-specific splicing and variant C-termini. Alternative splicing at the 3′ end enables generation of transcripts containing one of …
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The Sodium Pump Regulates Sperm and Sertoli Cell Function
… during routine semen evaluation) influence bull fertility and therefore the efficiency of cattle production. New knowledge regarding the molecular basis of spermatogenesis and sperm function will enable us to develop evidence-based approaches for improving fertility. The overall aim of this …
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The Role of 5-Hydroxymethylcytosine in Genome Instability
… that must be correctly achieved to maintain male fertility. PRM2 is subject to proteolytic processing during spermiogenesis, in which the N-terminus is cleaved following DNA binding. Using a PRM2 N-terminus-deficient mouse model, I find that the cleaved region of PRM2 is essential for sperm …
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Functional Analysis of the miR156 Regulatory Network in Arabidopsis Siliques
… regulates pollen production, and thus affects male fertility in Arabidopsis thaliana. I present evidence that SPL2 binds to the 5’UTR of the ASYMMETRIC LEAVES 2 (AS2) gene in vivo, indicating that AS2 acts downstream of SPL2. When compared to wild-type plants, AS2 loss-of-function mutants share …
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The role of mir-290-295 in murine embryonic and germ cell development
… In surviving mir-290-295 deficient embryos, female but not male fertility is compromised. This impairment in fertility arises from a defect in migrating primordial germ cells and occurs equally in male and female mutant animals. Male mir-290-295-- mice, due to the extended proliferative …
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Characterization of Phosphatidylserine Expression in Bovine Sperm
Many factors influence male fertility, and conventional fertility evaluations are not able to reliably identify sub-fertile animals. The overall goal of this work was to explore the expression of phosphatidylserine (PS) on bovine sperm and investigate what factors may impact it, as previous …
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The role of Cdyl and CDY in mammalian spermatogenesis
… CDY is thought to have an important role in male fertility and spermatogenesis. However, human studies have not yet been able to directly implicate CDY in male infertility. Even though mouse Cdyl is not located on the Y chromosome, it is the closest known mouse homologue of human CDY and is …
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Mitochondrial Haplotype Influences the Impact of Simulated Climate Warming on a Tropical Ectotherm
… minor compared to catastrophic consequences for male fertility and female fecundity, pointing to reproduction as the life history stage that is most vulnerable to climate warming. Still to be investigated was the potential for a genetically-based response to elevated temperature. In the study …
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Hyperactivated motility in human sperm: regulation, function and significance in IVF
… is a movement pattern elicited by sperm in the female reproductive tract. The transition to hyperactivated movement is characterised by an increase in amplitude and a decrease in symmetry of flagellar bending. The resulting forceful, unequal waveforms produce a swimming style that is erratic and …
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Genetic Analysis of The Function of The Drosophila Doublesex-Related Factor Dmrt93B
… have no significant effect on gonad formation or male fertility. Analysis of GAL4-driven GFP reporter expression indicates that the dmrt93B promoter activity is highly specific to neurons in the suboesophageal and proventricular ganglion in larva and adult of both sexes suggesting a possible role …
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