Global ETD Search
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Showing 1 to 6 of 6 for “"malate-synthase"”.
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The glyoxylate shunt as a target for antibacterial intervention in Pseudomonas aeruginosa
… comprised of two enzymes: isocitrate lyase and malate synthase G, and allows the synthesis of cellular constituents from C2 nutrient sources, bypassing the decarboxylation steps of the citric acid cycle when glucose is not available. The glyoxylate shunt has potential as a new antibacterial …
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Glyoxylate Metabolism in Mycobacterium smegmatis
… mice. The other enzyme of the glyoxylate shunt, malate synthase (MLS), may also be important for the intracellular survival of the tubercle bacillus; yet, no studies have been done to determine its in vivo role. We present here results of genetic studies of MLS in the saprophyte Mycobacterium …
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Synthesis and antibacterial evaluation of diverse small molecules
… inhibition of a key P. aeruginosa drug target, malate synthase G. Together the findings in this dissertation encourage the development and application of divergent synthesis and unbiased screening methods in antibacterial discovery.
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MarR Family Transcriptional Regulators from Streptomyces coelicolor
… sacA (encoding aconitase), aceB1 (encoding malate synthase), mdh (encoding malate dehydrogenase) and idh (encoding isocitrate dehydrogenase). Moreover, the divergent tam-tamR gene pairs and the predicted TamR binding sites are highly conserved in the promoter regions of its target genes in …
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Metabolic pathways of Campylobacter fetus
… bypass, and was found in the three strains. Malate synthase was not detectable in either of them, but can be induced by growing the organisms in BM + 0.5% glucose or 0.5% acetate. No pyruvate dehydrogenase was found in either strain. Pyruvate was carboxylated by pyruvate carboxylase in H840 …
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Genom- und Transkriptionsanalyse von <i>Bacillus licheniformis</i> DSM13 - einem Organismus mit großem industriellem Potential
… der Gene einer Isocitrate-Lyase und einer Malat-Synthase, welche die Schlüsselenzyme des Glyoxylatzyklus darstellen, als auffällige Abweichung. Diese Enzyme befähigen den Organismus zum Wachstum auf Substraten, wie 2,3-Butandiol und Acetat, bei welchen es sich um typische Endprodukte von Bacilli …