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Showing 1 to 20 of 150 for “"major histocompatibility complex"”.
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The Major Histocompatibility Complex in Rabbits
… evolutionary processes as they take place. The major histocompatibility complex (MHC) is a key component of the immune system’s response to both fight disease and maintain health. Present in all jawed vertebrates, the MHC has played a key role in immunocompetence for over 400 million years. Its …
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The genomic anchors of the human major histocompatibility complex
… The aim of this thesis is to use the human Major Histocompatibility Complex (MHC) as model region to provide novel insights into the relationship between chromatin folding mediated by MARs and gene expression. This large locus contains critical genes for immunity and is associated with more …
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Diversity and Evolution in the Avian Major Histocompatibility Complex
… of the commercial poultry industry. The chicken Major Histocompatibility Complex (MHC) has been particularly well-studied, since variation at the chicken MHC is strongly associated with resistance and susceptibility to disease, particularly infectious pathogens. Furthermore, its 'minimal …
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Identification of major histocompatibility complex haplotypes in goldfish, Carassius auratus
… of techniques for observing variability at the major histocompatibility complex (MHC) of fishes could prove an important first step in understanding the genetic bases of disease resistance. In this study, using goldfish (Carassius auratus) as a model system, three approaches to generating …
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Associations of egg production with the major histocompatibility complex in broiler breeder hens
This study documents effects of the major histocompatibility complex (MHC) on reproductive traits in a flock of Cobb X Cobb broiler breeder hens. The objective was to determine if the MHC affects reproduction of non-congenic broiler breeder hens. Genomic DNA was isolated from 35 hens. Restriction …
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Structure studies of the human class II major histocompatibility complex protein HLA-DR1
Major Histocompatibility Complex (MHC) proteins are heterodimeric membrane glycoproteins that bind antigens in the form of short peptides within the cell and present them to the T cell receptors on the surface T cells. In this thesis work, the structural aspects of the human class II MHC protein …
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Modulation of Ly49A+ Natural Killer Cell Licensing by Major Histocompatibility Complex Class I Alleles
… that react to cells lacking self-MHC: major histocompatibility complex) class I molecules, such as transformed or virally infected host cells and allogeneic bone marrow. This reactivity is mediated by inhibitory receptors for MHC class I that block the ability of activation receptors to …
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Identification and characterization of a chicken major histocompatibility complex class II[beta] gene promoter
<p>The major histocompatibility complex (MHC) contains a variety of genes. Among them, the class II genes encode proteins involved in antigen presentation to helper T cells, a key step in initiating immune responses. The regulation of class II gene expression has been extensively studied in …
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The Major Histocompatibility Complex (MHC) and the proteasome-ubiquitin pathway in T cell development
The essential role of classical MHC molecules in T cell development as well as the proteasome role in antigen processing for MHC-mediated antigen presentation to T cells is well established. However, the contribution of nonclassical MHC molecules, the signals evoked by the MHC-TCR interactions, the …
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Major histocompatibility complex diversity in an urban Chacma baboon (Papio ursinus) population: Implications for conservation
Since the 15th century, human activity has altered and degraded nearly half of the available land of the Cape Peninsula, South Africa; this has resulted in significant restriction and fragmentation of the historic geographic range of the peninsula's Chacma baboon (Papio ursinus) population.
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The folding, assembly, and intracellular transport of murine class I major histocompatibility complex heavy chains
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) VS NON-MHC INFLUENCES ON RESPONSE TO RSV-INDUCED TUMORS IN CHICKENS
<p>The MHC of the chicken (B complex) has been shown to exert a decisive influence on the fate of Rous sarcoma virus (RSV)-induced tumors. However, noninbred chickens with identical B genotypes and inbred lines indistinguishable at the MHC have demonstrated considerable variation in response to RSV …
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CROSS-REACTIVITY BETWEEN MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN AND ROUS SARCOMA VIRUS-INDUCED TUMOR ANTIGEN IN CHICKENS
<p>Cross-reactivity between major histocompatibility complex (MHC) antigen and Rous sarcoma virus (RSV)-induced tumor associated antigen (TAA) in chickens was investigated. The B erythrocyte allcantigen locus was the genetic marker for the MHC. B2B2 and B5B5 chickens from crosses of highly inbred …
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Variation at Major Histocompatibility Complex Class I Loci In Two Killifish Species with Reduced Genetic Variance
… to promote and preserve genetic variation at Major Histocompatibility Complex (MHC) class I loci was examined in two fish species known to have low genetic variation either as a consequence of their breeding system or population structure. The tempo and modes of molecular evolution acting on …
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Processing of Exogenous Hen Egg-White Lysozyme for Presentation on Major Histocompatibility Complex Class I and II Molecules
<p>Exogenous antigen typically enters the major histocompatibility complex: MHC) class II system for processing and presentation to CD4+ T cells. Experiments conducted by Michael Bevan in the 1970s demonstrated that exogenous antigen can also enter the MHC class I system and cross-prime CD8+ T …
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Does variability matter? Major histocompatibility complex (MHC) variation and its associations to parasitism in natural small mammal populations
… Variability at immune genes, such as the major histocompatibility complex (MHC) genes, is assumed to be a very powerful and effective tool to keep pace with diverse and rapidly evolving pathogens. In my thesis, I studied natural levels of variation at the MHC genes, which have a key role …
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Host-parasite co-evolution and genetic variation at the major histocompatibility complex in the Trinidadian guppy (poecilia reticulata)
The Major Histocompatibility Complex (MHC) is a region of the vertebrate genome believed to be responsible for an individual's ability to detect and recognise invading parasites. The MHC molecule has been shown to bind to short fragments of parasite and present these to the adaptive immune system. …
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