Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 174 for “"macular"”.
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Genetic Analysis of Macular Telangiectasia
Macular telangiectasia type 2, or MacTel, is an adult onset retinal disease that causes progressive loss of central vision, usually beginning between the 5th and 7th decades of life. Macular degenerative diseases comprise a large portion of the blinding diseases affecting people over the age of 50. …
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Grosor macular luego de tratamiento con Ranibizumab o Bevacizumab en degeneración macular relacionada con la edad
Introducción: El manejo actual de la degeneración macular relacionada con la edad (DMRE) neovascular está basado en la terapia antiangiogénica con inhibidores del factor de crecimiento vascular endotelial (VEGF) entre los cuales se encuentra el Ranibizumab y el Bevacizumab. El seguimiento se hace …
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Investigating determinants of macular pigment optical density and macular pigment distribution in adults aged 45--73: Can enhanced analytical techniques improve the ability to predict macular pigment status?
… of dietary, sex, and biochemical factors to macular pigment optical density (MPOD) and macular pigment (MP) distribution in 108 adults. Dietary assessment tools were evaluated for their ability to predict MP status. Macular pigment was assessed at four foveal sites and one parafoveal site. An …
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Advanced imaging biomarkers in age-related macular degeneration
Η ηλικιακή εκφύλιση της ωχράς κηλίδας, είναι μία κύρια αιτία σημαντικής μείωσης της όρασης παγκοσμίως, ενώ η επίπτωση της εκτιμάται ότι θα αυξηθεί σημαντικά. Η αναγνώριση πρώιμων βιοδεικτών που θα σημάνουν την αυξημένη πιθανότητα μετάπτωσης από πρώιμα σε πιο προχωρημένα στάδια της νόσου, που …
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Diabetic macular oedema: the role of steroids and VEGF
… advances in controlling diabetes, diabetic macular oedema remains the leading cause of blind registration in the working population in England and Wales. The only proven effective treatment for diabetic macular oedema is laser photocoagulation. However this treatment has limited benefits …
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Impact of macular pigment optical density on photophobia threshold
… where they are collectively referred to as macular pigment (MP). By absorbing short-wavelength light, MP may attenuate photophobia (PP)---visual discomfort induced by normal light exposure---for targets composed of short-wavelength light. The aim of this study was twofold: first, to …
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TGF-beta 1 PATHWAY AND AGE-RELATED MACULAR DEGENERATION
… mimics pathologic conditions such as age-related macular degeneration (AMD) using amyloid-beta (Abeta) oligomers, and assess the effect of TGF-beta 1. Furthermore a topical formulation of transforming growth factor 1 (TGF-beta 1) was developed; and TGF-beta 1 ocular pharmacokinetics profile was …
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Effects of combination therapies on age-related macular degeneration
Age-related macular degeneration (AMD) is the most common cause of vision loss in America for people over the age of 60. Due to damage to the retina, symptoms normally include blurred central vision, difficulty reading, and seeing shadows. While there is no cure for the disease, there are …
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Visual field and structural alterations in age-related macular degeneration
… of patients with varying degrees of agerelated macular degeneration (AMD). The relationships between structure and function were investigated for both standard and short-wavelength automated perimetry (SWAP). Factors known to influence the measure of visual field progression were considered, …
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Image-Based Biomarkers in Retinal Disease: Applications in Macular Degeneration
The purpose of this research was to investigate and objectively quantify image-based biomarkers of ocular injury and disease using a combination of non-invasive high resolution imaging techniques. High resolution imaging and sensing provides the basis for the diagnosis of most retinal diseases so …
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Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
… Among the back of the eye disorders, age-related macular degeneration (AMD) is one of the major ailments responsible for blindness worldwide. There is currently no effective treatment available to cure AMD completely. Anti-VEGF therapy is currently considered the treatment of choice. However, it …
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Rare genetic variants in patients with age-related macular degeneration
Contains fulltext : 148918.pdf (Publisher’s version ) (Open Access)
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Macular pigment optical density and academic achievement among preadolescent children
… accumulate in the macula of the neural retina as macular pigment and across all brain cortices of infants and adults. This preferential accumulation in the brain has led to the hypothesis that lutein may positively impact cognition, possibly through its anti-inflammatory and/or antioxidant …
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Novel nanocarriers to improve drug delivery for age-related macular degeneration
… of life of millions worldwide. Age-related macular degeneration (AMD) is ranked third on a global scale as one of the major back-of-the-eye disorders being responsible for blindness in elderly patients over 60 years. As there is no efficacious cure to completely prevent AMD, the invasive …
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Investigating the genetic and molecular basis of age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of blindness worldwide, affecting an estimated 50 million individuals aged over 65 years. Environmental and genetic risk-factors contribute to the development of AMD. An AMD-risk locus on chromosome 10q26 spans two genes, ARMS2 and HTRA1, …
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Connexin43 as a novel therapeutic target in age-related macular degeneration
Age-related macular degeneration (AMD) is the major cause of blindness in the elderly. There is currently no cure for AMD although several risk factors have been implicated in the pathogenesis and progression of the disease. These include oxidative stress, inflammation and vascular changes. …
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Benefits and accessibility of OCTA imaging for diabetic retinopathy and macular edema
Diabetic retinopathy (DR) and diabetic macular edema (DME) are among the leading causes of vision loss worldwide. Early detection and timely intervention are crucial in decreasing the risk of vision impairment worldwide. Optical Coherence Tomography Angiography (OCTA) is an emerging imaging …
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Improving face perception and quality of life in age-related macular degeneration
… and good quality of life. Age-related macular degeneration (AMD) is a progressive eye condition that damages central vision required to see faces clearly. This thesis aims to investigate potential means to improve quality of life in AMD, via a two-pronged approach. The first prong …
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