Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1305 for “"macrophages"”.
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TNFalpha expression in monocytes/macrophages
… bacteria-induced TNF production in mouse macrophages. Effects on TNF expression when cells are pretreated with dexamethasone are a decrease in gene transcription as well as posttranscriptional inhibition. Okadaic acid, a protein phosphatase inhibitor, seems to overcome the …
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Phagosome proteomes in activated macrophages
Macrophages play key roles in innate and adaptive immune systems not only in the response to pathogens but also in tissue homeostasis. They are extremely plastic and recognize external stimuli such as cytokines with substantial changes to the proteome and molecular functions. One major macrophage …
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Intestinal macrophages in health and inflammation
… large intestinal mucosa contains a vast pool of macrophages (mφ) that are close to the local bacterial flora and have several unique phenotypic and functional properties compared with other mφ populations. Although human colonic mφ retain some of the hallmark functions of mφ, such as the ability …
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Manipulating macrophages to enhance liver regeneration
… therapy for life-threatening cases. Hepatic macrophages are crucial for innate immune integrity and effective hepatocyte proliferation. The macrophage may therefore present a novel therapeutic target to enhance regeneration following acute liver injury. In this thesis I describe the …
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Intracellular parasitism of macrophages by Cryptococcus
… able to survive inside these cells (especially macrophages), thus acting as intracellular parasites. This intracellular phase is thought to underlie the ability of the pathogens to remain latent for long periods of time within infected individuals. Here, we demonstrate that cryptococci can also …
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Mapping and modeling macrophages in tuberculosis
… to identifying new clinical interventions. Macrophages in tuberculosis granulomas are an archetype of these phenomena. Pinpointing the cellular states and features required for effective responses to vaccination or Mycobacterium tuberculosis infection remains challenging. Recent advances …
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Characterization of Phagosome-Lysosome Fusion in Macrophages
… phagosome-lysosome (P-L) fusion in intact mouse macrophages. Lysosomes were labeled with the fluorescent vital dye acridine orange and the rate and extent of their fusion with yeast-containing phagosomes was monitored by fluorescence microscopy. Fusion was also assayed by electron microscopy, …
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Interaction between Leishmania parasites and mammalian macrophages
… diseases known under the name of leishmaniasis. Macrophages represent the main host. Hence the interaction between Leishmania and macrophages is a fundamental step in the development of the disease. Many studies have been undertaken to understand early stages of the parasite interaction with …
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Role of Macrophages in Ocular Surface Fibrosis
… activation and polarization and whether macrophages could cause the transdifferentiation of ocular surface fibroblasts into myofibroblasts, thus contributing to oGVHD-associated fibrosis.</p> <p>Bone marrow cells were cultured in M-CSF to obtain M0 macrophages, which were subsequently …
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Factors influencing vitamin a secretion in macrophages
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Human Chimeric Antigen Receptor Macrophages For Cancer Immunotherapy
… microenvironment (TME), where tumor associated macrophages (TAMs) are often the most abundant infiltrating immune cell. Currently, macrophage orientated immunotherapeutic approaches under clinical development in oncology seek to reduce TAM infiltration or enhance TAM phagocytosis. We …
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Regulation of cytokine and chemokine production in macrophages
Macrophages are an important part of the innate immune response. They are capable of sensing pathogens via pattern recognition receptors (PRRs) and then initiating an appropriate inflammatory response. Dysregulation of the inflammatory response can result in chronic inflammation and tissue damage. …
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Tumor Associated Macrophages in a MaFIA Mouse Model
Recent evidence has shown the important role of macrophages in both tumor development and progression. To investigate the role of macrophages we used a mouse model known as MaFIA (Macrophage Fas Induced Apoptosis) mice that allows for the selective deletion of macrophages. Mice were given melanoma …
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Characterization of cholesterol 25-hydroxylase expression in human macrophages
… with PMA for 72 hours for differentiation into macrophages. Differentiated macrophages or Microglial cells were stimulated with either TLR-agonists, pro-inflammatory cytokine, or interferons, and CH25H mRNAs expression levels were measured by qPCR. Results In this study, we show that CH25H is …
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Modulating the Inflammatory Response of Macrophages on Biomaterial Surfaces
… implanted materials is carried out primarily by macrophages, which recognize DAMPs and other surface-adsorbed proteins with toll-like receptors (TLRs), initiating an inflammatory response. Macrophages play key roles in inflammatory and wound healing responses due to their ability to transition …
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Modulation of the Serotonin Reuptake Transporter in RAW264.7 Macrophages
… of 3H-5HT uptake. The 5-HT uptake in RAW264.7 macrophages was more than 10-fold that of peritoneal macrophages, indicating that these cells are an excellent model for studying regulation of the SERT. Activation of macrophages with lipopolysaccharide (LPS) increased SERT activity in a time- and …
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Experimental Models of Mycobacterial Replication and Killing in Macrophages
<p>This thesis investigates how human mononuclear phagocytes regulate the growth of mycobacteria. Previous studies carried out in our laboratory suggested that cell turnover [apoptosis and necrosis] within a granuloma may contribute to the control of mycobacterial infection. The experiments …
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