Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"macrophage responses"”.
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Molecular mechanisms responsible for the dynamic modulation of macrophage responses to varying dosages of lipopolysaccharide
… different dosages in murine bone-marrow-derived macrophages (BMDM). The pro-inflammatory cytokine IL-12 was most strongly induced by intermediate LPS dosages, with very low or high doses inducing less robust IL-12 production. Knockout of the inhibitory TLR4 pathway molecules Lyn or IRAK-M …
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LPS from subgingival plaque and the periodontal pathogen Porphyromonas gingivalis, its effect on M1 and M2 macrophage responses and potential as a biomarker
… pattern that instigates an immune response from macrophages (MΦ), key orchestrators of host immune response. Repetitive exposure Is also demonstrated to induce a quiescent state known as endotoxin tolerance, thought to be a protective mechanism but which may also confer protective benefits to …
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Type 2 Diabetes Impairs Interleukin-4 Function in Macrophages and Amplifies the Brain-Based Neuroimmune Response
Neuroimmunity is mediated by activated macrophages that secrete proinflammatory cytokines in response to immune insult. These messenger molecules communicate immune status to the brain to elicit important metabolic and behavioral changes that act to minimize transmission of infection and maximize …
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M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… leads to progressive kidney injury and fibrosis. Macrophages play a central role in this process because of their functional plasticity and ability to respond to environmental cues. Classically activated M1 macrophages promote inflammation through cytokines such as IL-1β, IL-6, and TNF-α, whereas …
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Toll-like receptor mediated responses to adsorbed damage-associated molecular patterns on biomaterial surfaces
… tissues to stimulate sterile inflammatory responses via Toll-like receptors (TLRs) and other pattern recognition receptors. The work in this thesis explored the contribution of cellular damage molecules in cell lysate and TLR signalling in macrophage responses to a range of non-resorbable …
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Diffuse Brain Injury Triggers Ultra-Rapid Perisomatic Traumatic Axonal Injury, Wallerian Change, and Non-Specific Inflammatory Responses
… see if this non-lethal neuronal pathology evoked responses comparable to those following focal injury. Microglia / macrophage responses within diffusely injured loci uncomplicated by focal pathology were explored using LM, TEM, and confocal evaluations as was albumin immunoreactivity to assess …
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Investigating CDK9 inhibitor treatment during the innate inflammatory and regenerative response in a zebrafish model of cardiac injury
Neutrophils and macrophages are crucial effectors and modulators of cardiac repair following myocardial infarction (MI). Sustained neutrophilic inflammation is detrimental for cardiac repair and associated with adverse MI outcomes. An attractive therapeutic strategy to treat acute inflammatory …
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Understanding functional mechanisms of genetic susceptibility to mycobacterial infection
… study the role of ASAP1 in dendritic cells and macrophages, cells that play critical roles during mycobacterial infection. I demonstrated that in these cells ASAP1 is essential for migration and phagocytosis of mycobacteria. I characterized proteins that ASAP1 interacts with during mycobacterial …
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Molecular Mediators of Macrophage Foam Cell Formation and Atherosclerosis and their Pharmacological Modification
… plaque is the accumulation of cholesterol-laden macrophages, called foam cells. Uncontrolled inflammation in plaques makes them “unstable” and vulnerable to rupture and thrombosis, which causes complications, such as myocardial infarction (MI) in the case of atherosclerotic coronary artery …