Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"macrophage polarization"”.
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Transcriptomic profiling of macrophage polarization
Macrophages perform a wide variety of crucial, and sometimes contradictory, functions. While “pro-inflammatory” activities like fighting off infections and “anti-inflammatory” activities like wound-healing traditionally have been attributed to M1 and M2 macrophage subsets, studies of macrophages in …
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Impact of Primary Myoblasts on Macrophage Polarization In-Vitro
… in murine models and are known to interact with macrophages, which are immune cells that are primary regulators of arteriogenesis. Macrophages can polarize to inflammatory (M1) and regenerative (M2) phenotypes, with the M2 phenotype promoting enhanced arteriogenesis. This interaction suggests …
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Macrophage Polarization (M1/M2) and its Role in Wnt5a Secretion/Expression in Atherosclerosis
<p>Macrophages play an important role in the formation of atherosclerotic lesions and their progression. The presence of M1 and M2 macrophages in human atherosclerotic lesions has been suggested. Wnt5a is a noncanonical member of the wingless family of proteins that is expressed in human …
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Non-resolving pro-inflammatory macrophage polarization by super-low doses of bacterial endotoxin
… in increased plaque size and instability in a macrophage-dependent manner in a mouse model of atherosclerosis. Further, we showed that super-low dose LPS (SLD-LPS) treatment was able to inhibit lysosomal fusion in immortalized macrophages. However, this was done under more acute treatment …
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Contribution of Secretion Systems to Macrophage Polarization and Cell Death During Burkholderia pseudomallei Infection
… have on the immune response by evaluating macrophage polarization and cell death. Using two mutant strains, ∆bicA and ∆hcp1, as case studies, we demonstrate that there is a differential macrophage polarization and apoptosis response. Together, they represent host response elements that are …
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IL-4/IL-13-inducible lincRNA-MIR99AHG regulates macrophage polarization and promotes intracellular survival of Mycobacterium tuberculosis
… lincRNA-MIR99AHG, which is upregulated in macrophages upon IL-4/IL-13 stimulation and downregulated after Mtb infection and in active TB patients. To evaluate the functional role of lincRNA-MIR99AHG, we employed antisense GapmeR-mediated lncRNA knockdown experiments. Knockdown of …
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The role and host-directed targeting of long non-coding RNAs in macrophage polarization during Mycobacterium tuberculosis infection
… (Mtb), evades host immune responses by skewing macrophage polarization towards a less microbicidal alternative state to avoid classical effector killing functions. However, the molecular details underlying these evasion mechanisms remain incomplete and current therapy is challenged with drug …
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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir
… antiretroviral drug therapy (ART). Infected macrophages, which represent a long-term viral reservoir have been shown to lead to viral rebound independently. In response to the environmental stimuli, macrophages can be polarized into different phenotypes: the pro-inflammatory M1 and the …
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Exploiting Multi-Cell Type Cultures to Elucidate Tumor Cell Features That Impact Macrophage Phenotype
… to tumorigenesis, angiogenesis and metastasis. Macrophages are key regulators of the immune landscape within the TME. The plasticity of macrophage phenotypes in the TME correlates with prognosis of NSCLC. Depending on their phenotype, macrophages in the TME can secrete pro-tumor cytokines and …
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Runx2 and Vascular Calcification
… of Runx2 on development of atherosclerosis and polarization of lesional macrophages. Removal of Runx2 did not affect monocyte/macrophage recruitment and atherosclerotic lesion size. Within lesions, we observed a strong shift in macrophage polarization toward an M2 polarization in atherosclerotic …
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Role of the NLRP3 Inflammasome in bacterial keratitis
… bacterial keratitis is not clearly understood. Macrophages play an important role in inflammation and infection and are known to produce the NLRP3 inflammasome. The NLRP3 inflammasome produces IL-1β a key pro-inflammatory mediator. The phenomenon of macrophage polarization during bacterial …
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Chemokine Ligand-3 (CCL3) as a Novel Mediator of Inflammatory Bowel Disease Activity
… system, driven in part by pro-inflammatory macrophage polarization. Chemokine ligand-3 (CCL3) is a chemokine known to mediate Th1 responses in inflammatory conditions and act to polarize M1 macrophages at the site of inflammation. CCL3 is upregulated in patients with IBD but its contribution …
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¿CHIOS MASTIC GUM FROM PISTACIA LENTISCUS AS A MODULATOR OF INFLAMMATION AND INTESTINAL BARRIER FUNCTION: AN IN VITRO AND CLINICAL INVESTIGATION.¿
… cells and lipopolysaccharide-stimulated THP-1 macrophages. Clinically, no significant differences were observed in the questionnaires and calprotectin levels, although a downward trend was noted for the latter (p=0.062). Faecal zonulin levels showed a significant decrease over time (p=0.017), …
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Effects of Keratin Biomaterial Therapeutics on Cellular and Inflammatory Mechanisms in Injury and Disease Models
… keratins to augment anti-inflammatory primary macrophage phenotypes and examining the influence of keratin biomaterials on cellular and inflammatory mechanisms in two models of injury and disease. Rodent models of blast induced neurotrauma (BINT) and severe osteoporosis were used to inform the …
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Investigating The Metabolic Progression of Glioblastoma With Hyperpolarized Magnetic Resonance
… process of natural killer cells as well as macrophage polarization are analyzed. Collectively, this work demonstrates the value of interrogating the metabolism of GBM and tumor-associated immune cells with hyperpolarized MRS and NMR spectroscopy.</p>
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Unraveling The Effects of Aerobic Exercise and Erk5 Signaling In The Solid Tumor Microenvironment Using Murine Models
… myeloid cells by exercise, including a change in macrophage polarization. Transgenic mice lacking ERK5 S496 phosphorylation presented a reversal in the effects of exercise in the tumor microenvironment, revealing a role of ERK5 in exercise-induced tumor microenvironment remodeling. Finally, we …
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M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… leads to progressive kidney injury and fibrosis. Macrophages play a central role in this process because of their functional plasticity and ability to respond to environmental cues. Classically activated M1 macrophages promote inflammation through cytokines such as IL-1β, IL-6, and TNF-α, whereas …
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The Mechanism of cGAMP Induced Antitumor Effect and Its Application in Treating Cancer and Antibody Generation
… Two, I reveal that cGAMP injection induces a macrophage population across various tumor types. These macrophages exhibit immune cell-attracting and antigen-presentation features, uncovering new mechanisms of cGAMP's antitumor effect. Chapters Three and Four discuss enhancing systemic antitumor …
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Pulmonary vascular malfunction and inflammation during Orientia tsutsugamushi infection
… or mortality of infected mice and modulated the macrophage and T cell populations in the lungs. These data suggest a pathogenic and regulatory role of neutrophils during scrub typhus. In addition to endothelial cells, O. tsutsugamushi has been shown to replicate in macrophages in vitro and in …
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UNRAVELLING MECHANISMSOF SCHWANN CELLS IN VESTIBULAR SCHWANNOMA AND THEIR IMPACT ON HEARING LOSS.
… of SCH was explored through the setup of SC-macrophage co-culture paradigm. We found a significant cross-talk between SCs and monocytes: naïve SCs were shown to modulate monocytes and macrophages toward an anti-inflammatory phenotype, and in parallel tumour-derived SCs induced a stronger …
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