Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"macrophage polarisation"”.
-
An Investigation into the Effects of Macrophage Polarisation on Interleukin-1 Expression
Macrophages are innate immune cells characterised by functional heterogeneity and plasticity. The prevailing dogma divides macrophages into two opposing subtypes: the pro-inflammatory M1 and anti-inflammatory M2 macrophages. Macrophages are also the main cell type that produces two powerful …
-
Investigating the phenotype and function of tissue-resident B cells in mouse and human non-lymphoid organs
… B cells were spatially co-localised with macrophages and had a profound effect on macrophage polarisation, promoting an anti-inflammatory M2 phenotype, an effect at least partially driven via interleukin (IL)-10. Finally, in human NLOs we found a similar enrichment for non-naïve less …
-
Repurposing itraconazole as a novel and promising therapeutic strategy for pancreatic cancer
… tumour milieu of pancreatic cancer by affecting macrophage polarisation, T cell heterogeneity, chemokine signalling, inducing transcriptional changes in immune cell populations and altering gut microbiome signatures. Ultimately, the addition of itraconazole to immunotherapy significantly …
-
Design and synthesis of ionisable amino-polyester lipid nanoparticles for extrahepatic RNA delivery
… the selected APE-LNPs was assessed in M0 and M1 macrophages to explore their potential for targeting immune cells. APE-LNPs achieved efficient mRNA delivery in both phenotypes, with distinct transfection profiles between activation states, providing insights into how macrophage polarisation …
-
The role of ERK5 signalling in macrophage behaviour during wound healing
… the role of a key immune cell in wound healing: macrophages and how a known regulator of macrophages in other contexts, ERK5, influences wound healing, using genetic and therapeutic manipulations targeted at ERK5, both in vitro and in vivo. Genetic in vivo hyperactivation of ERK5 causes a …
-
Characteristics of decidual macrophages and Hofbauer cells in placentas of HIV positive women on antiretroviral therapy
Macrophages are the most abundant immune cells at the maternal-foetal interface of term placentas. They play a role in regulating pregnancy, promoting immunological tolerance, and maintaining a homeostatic environment crucial for foetal development. Numerous studies have reported the dysregulation …
-
Mathematical modelling and investigation of oncolytic therapies for cancer: The role of macrophages in tumour-virus interactions
… Among these immune cells, macrophages represent one of the first line of defence against viral infections.<br/><br/>In this thesis, we start with a simple model that describes the interactions between a commonly-used oncolytic virus, the Vesicular Stomatitis Virus (VSV), and …