Global ETD Search
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Showing 1 to 19 of 19 for “"macrophage migration inhibitory factor"”.
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Role for Macrophage Migration Inhibitory Factor in Multiple Sclerosis
Il fattore di inibizione della migrazione dei macrofagi (MIF) è una citochina proinfiammatoria che svolge un ruolo importante nella patogenesi di numerosi disordini infiammatori e autoimmuni. Come tale, è un obiettivo terapeutico interessante per il trattamento di questi disturbi. Diversi dati …
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Expression of Macrophage Migration Inhibitory Factor in Behçet's disease
PURPOSE: Macrophage migration inhibitory factor (MIF) is a unique protein, participating in inflammation, immune response, and cell growth. Previous reports showed that MIF-173 G>C polymorphism or the MIF-794 [CATT]5-8 polymorphism and haplotypes containing these variants were associated with an …
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Molecular mechanisms of the unconventional secretion of macrophage migration inhibitory factor (MIF)
Macrophage migration inhibitory factor is a pro-inflammatory cytokine that plays a pivotal role in the pathogenesis of inflammatory disease such as septic shock and rheumatoid arthritis. The release of MIF from inflammatory cells is a common feature in these diseases, and a correlation between the …
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A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses
… of the pro-inflammatory pleiotropic cytokine, macrophage migration inhibitory factor (MIF). These two MIF-like sequences show 22% sequence identity when aligned with human MIF, and are most likely the result of gene duplication. The Lm1740MIF and Lm1750MIF genes (58% identity) are expressed in …
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Dissecting the impact of macrophage migration inhibitory factor (MIF) on host immune response
Macrophage migration inhibitory factor (MIF) has been implicated in mediating both innate and adaptive immune responses in inflammatory and infectious diseases. The sequence and structure of MIF is highly conserved across the avian phylogeny, which underlies high sequence homology and functional …
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The Role of Immunological Receptors CD74 and CD44 in Association with the Macrophage Migration Inhibitory Factor (MIF) on Human Breast Cancer Derived Cells
… synergy and are susceptible to the effect of the macrophage migration inhibitory factor (MIF). MIF is a 12.5 kDa chemokine-like inflammatory mediator, whose ligand is the transmembrane receptor CD74. Recent data suggests that CD74 is involved in proinflammatory responses and tumorigenesis but …
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Molekulare Steuerung des Mamma-Karzinom-Verhaltens durch das inflammatorische Zytokin MIF
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine and mediator of acute and chronic inflammatory diseases. MIF is overexpressed in various tumours and has been suggested as a molecular link between chronic inflammation and cancer. In the context of the present study we …
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Harnessing the Immunomodulatory Potential of Radiofrequency Ablation to Improve Therapeutic Outcomes in Pancreatic Ductal Adenocarcinoma
… deposition, a decrease in the expression of macrophage migration inhibitory factor (MIF) levels, and elevated hypoxia-inducible factor 2-alpha (HIF2α) expression were among the important componentsof the TME that were examined. Our data shows notable tumor-associated changes post-RFA, …
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Uncovering Biological Mechanisms of Immunomodulatory Biomaterials for Encapsulated Cell Therapies
… of E9, an anti-fibrotic biomaterial coating, on macrophage behavior. We find that E9 downregulates CD86 surface expression when immobilized on a biomaterial surface. In addition, E9 downregulates the secretion of several cytokines including MCP-1 and VEGF and upregulates the secretion of IL-1β …
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Functional Characterization of the Avian Inflammatory Mediators Nod1, MIF and IL-22
… for mammalian Nod1 or Nod2. A signal mediator, macrophage migration inhibitory factor (MIF) inhibits the random migration of macrophages. Chemotaxis assay using recombinant ChMIF (rChMIF) revealed a substantial decrease in migration of macrophages. qRT-PCR analysis revealed that the presence of …
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Regulation of CD74 expression in response to Human Interferon Gamma and Lipopolysaccharide on Human Trophoblast Derived Cells: Relevance for Human Feto-Maternal Tolerance.
… class II- mediated antigen presentation and a macrophage migration inhibitory factor (MIF) receptor. CD44 is the signalling component of the MIF-CD74 receptor complex. The expression of CD74, MIF and CD44 was studied in the human trophoblast-derived cell lines JEG-3 and ACH-3P by RT-PCR, flow …
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Expressão do fator inibitório da migração de macrófagos e do fator de permeabilidade vascular em lesões da cérvice uterina induzidas pelo papilomavírus humano
… for non-melanoma skin cancer and breast cancer. Macrophage migration inhibitory factor (MIF) is produced by different cell types and participates in a complex chain of events that favors the process of carcinogenesis, being possible to observe a high expression level in almost all types of human …
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A Signal to Divide: Apoptotic Extracellular Vesicles as Carriers of Mitogenic and Immunogenic Signals
… esAEVs exhibit surface localization of macrophage migration inhibitory factor (MIF), stimulating both proliferative and immunogenic effects on recipient cells. MIF on esAEVs promote compensatory proliferation of epithelial stem cells and influence macrophage surveillance. Interestingly, …
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Antiapoptotische Wirkungen des Makrophagen-migrationsinhibierenden Faktors (MIF) auf das Tumorsuppressorprotein p53 bei der ROS-induzierten Apoptose
… (PI3K-Akt-Pathway) effects of the cytokine MIF (Macrophage Migration Inhibitory factor) have been examined and brought in connection with antiapoptotic and pro-proliferative effects. The functions as redox-active cytokine (redox acting cytokine = "Redoxkine"), which have been linked to …
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Μελέτη του ρυθμιστικού ρόλου του παράγοντα αναστολής της μετανάστευσης των μακροφάγων (MIF) στην επίδραση των κορτικοειδών στην παραγωγή μεταλλοπρωτεασών και των ενδογενών αναστολέων τους, κυτταροκινών και κολλαγόνου στο ρινικό πολύποδα
Στην παρούσα διατριβή μελετήθηκε η έκφραση του παράγοντα αναστολής της μετανάστευσης των μακροφάγων (MIF) στον ιστό από ρινικό πολύποδα αλλά και στον φυσιολογικό ρινικό βλεννογόνο, καθώς και η ικανότητα αυτού να εξουδετερώνει την ανασταλτική δράση των γλυκοκορτικοειδών (ΓΚ) στην επαγόμενη από …