Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"macrophage migration"”.
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Studies on Macrophage Migration in Pathological Contexts
Macrophages play key roles following nerve injury releasing cytokines and chemokines thought to be involved in the development and maintenance of neuropathic pain. ATP is a transporter of chemical energy, but can also act as an extracellular signalling molecule that signals through purinergic …
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ROLE OF P50 NF-KB IN MACROPHAGE MIGRATION
Tumor Associated Macrophages (TAM) and lipopolisaccharide- (LPS)-tolerant macrophages share several characteristics, such as a massive accumulation of the p50 NF-B homodimer in the nucleus and the incapacity to express strong inflammatory programs (eg. impaired TNF production) in response to …
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Role for Macrophage Migration Inhibitory Factor in Multiple Sclerosis
Il fattore di inibizione della migrazione dei macrofagi (MIF) è una citochina proinfiammatoria che svolge un ruolo importante nella patogenesi di numerosi disordini infiammatori e autoimmuni. Come tale, è un obiettivo terapeutico interessante per il trattamento di questi disturbi. Diversi dati …
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Expression of Macrophage Migration Inhibitory Factor in Behçet's disease
PURPOSE: Macrophage migration inhibitory factor (MIF) is a unique protein, participating in inflammation, immune response, and cell growth. Previous reports showed that MIF-173 G>C polymorphism or the MIF-794 [CATT]5-8 polymorphism and haplotypes containing these variants were associated with an …
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Dissecting the impact of macrophage migration inhibitory factor (MIF) on host immune response
Macrophage migration inhibitory factor (MIF) has been implicated in mediating both innate and adaptive immune responses in inflammatory and infectious diseases. The sequence and structure of MIF is highly conserved across the avian phylogeny, which underlies high sequence homology and functional …
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The Involvement of Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) as a Critical Modulator of Macrophage Migration
Macrophage migration, an essential component of many biological processes and pathologic conditions, is mediated by integrated cellular signaling processes and cytoskeleton rearrangement. Recent advances indicate that the innate immunity signaling process plays a key role in the regulation of …
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The Role of Immunological Receptors CD74 and CD44 in Association with the Macrophage Migration Inhibitory Factor (MIF) on Human Breast Cancer Derived Cells
… synergy and are susceptible to the effect of the macrophage migration inhibitory factor (MIF). MIF is a 12.5 kDa chemokine-like inflammatory mediator, whose ligand is the transmembrane receptor CD74. Recent data suggests that CD74 is involved in proinflammatory responses and tumorigenesis but …
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Splenic Regulation Of Macrophage Activity In Mice Infected With Listeria Monocytogenes
… The regulatory role of the spleen over macrophage activation in mice was investigated. The macrophage migration inhibition test was used to measure in vitro macrophage activity. Macrophages from splenectomized, infected mice were shown to have increased migration and therefore increased …
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LATE PROTECTIVE EFFECTS OF NETRIN-1 AND ADENOSINE A2B RECEPTOR ACTIVATION IN THE MURINE ACETAMINOPHEN HEPATOTOXICITY MODEL
… translocation; in contrast, netrin-1 promoted macrophage migration and liver regeneration. Its receptor adenosine A2B receptor (A2BAR) was highly induced at late time points and blocking its receptor could remove its late protective effects, indicating that netrin-1 through its receptor A2BAR, …
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Therapeutic Approaches to Insulin Resistance and Type 2 Diabetes
… have suggested a role for this receptor in macrophage infiltration into adipose tissue to augment insulin resistance through an unknown mechanism. Overexpression studies revealed GPR21 to be a constitutively active receptor, which couples Gαq type G proteins leading to the activation of the …
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Tumor microenvironmental control of metastasis : effects of the immune cells and physical forces on cell migration
… can influence metastasis. Specifically, macrophage, one of the most abundant tumor-associated stromal cell types, has been shown to assist cancer cell invasion. However, exactly how macrophages affect the different aspects (e.g. speed and persistence) of cancer cell migration, especially …
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Cannabinoid Modulation of Chemotaxis of Macrophages and Macrophage-like Cells
… reported to modulate functional activities of macrophages. It is recognized that macrophages express primarily the CB2 cannabinoid receptor, but recent studies indicate that its expression is differential in relation to activation state with maximal levels occurring when cells are in …
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Investigating CDK9 inhibitor treatment during the innate inflammatory and regenerative response in a zebrafish model of cardiac injury
Neutrophils and macrophages are crucial effectors and modulators of cardiac repair following myocardial infarction (MI). Sustained neutrophilic inflammation is detrimental for cardiac repair and associated with adverse MI outcomes. An attractive therapeutic strategy to treat acute inflammatory …
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Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration
… Instrumental in this regenerative process are macrophages, Schwann cells and the production of inflammatory cytokines. The production of inflammatory cytokines from macrophages and Schwann cells needs to be tightly regulated to ensure efficient regeneration and to prevent chronic inflammation. …
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Unravelling the anti-inflammatory mechanisms of dietary fatty acids
… of this work was to elucidate such mechanisms. Macrophages are a key component of the innate response, which express toll-like receptors (TLRs). Ligation of TLR4, by its ligand lipopolysaccharide (LPS), results in macrophage activation. This study demonstrates that the n-6 derivative, conjugated …
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Oxime Click-crosslinked Cryogels to Quantify and Target Tumour-associated Macrophage Invasion in Hodgkin Lymphoma
… on targeting malignant cells. Tumour-associated macrophages (TAMs) are associated with poor prognosis and resistance to therapy; however, there remains an unmet need for a suitable pre-clinical model to identify macrophage-targeting therapeutics. We analyzed the HL extracellular matrix (ECM) in …
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Harnessing the Immunomodulatory Potential of Radiofrequency Ablation to Improve Therapeutic Outcomes in Pancreatic Ductal Adenocarcinoma
… deposition, a decrease in the expression of macrophage migration inhibitory factor (MIF) levels, and elevated hypoxia-inducible factor 2-alpha (HIF2α) expression were among the important componentsof the TME that were examined. Our data shows notable tumor-associated changes post-RFA, …
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Uncovering Biological Mechanisms of Immunomodulatory Biomaterials for Encapsulated Cell Therapies
… of E9, an anti-fibrotic biomaterial coating, on macrophage behavior. We find that E9 downregulates CD86 surface expression when immobilized on a biomaterial surface. In addition, E9 downregulates the secretion of several cytokines including MCP-1 and VEGF and upregulates the secretion of IL-1β …
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