Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 876 for “"macrophage"”.
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Cytoskeletal Protein Phosphorylation in the Murine Macrophage and Its Relationship to Macrophage Activation
Made available in DSpace on 2014-12-16T06:35:39Z (GMT). No. of bitstreams: 1 8521760.pdf: 2986168 bytes, checksum: dba94e02f83309292beff25ae06763fa (MD5) Previous issue date: 1985
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Transcriptomic profiling of macrophage polarization
Macrophages perform a wide variety of crucial, and sometimes contradictory, functions. While “pro-inflammatory” activities like fighting off infections and “anti-inflammatory” activities like wound-healing traditionally have been attributed to M1 and M2 macrophage subsets, studies of macrophages in …
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Macrophage – cryptococcus interactions during cryptococcosis
… Cryptococcus can survive and proliferate within macrophages, and is also capable of escaping into the intracellular environment via a non-lytic mechanism (‘expulsion’) and can be transferred directly from one cell to another (lateral transfer). In the first part of this thesis, I demonstrate that …
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Macrophage differentiation: A heterogeneous theory
"Functional heterogeneity of macrophage populations has been characterized however, questions remain regarding the mechanisms underlying the development of this heterogeneity. A procedure was developed to molecularly phenotype colonies of bone marrow-derived macrophage(s) (BMDM). Gene expression …
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Development of Novel Macrophage Imaging Agents
Macrophages are an important class of cell involved in host defence and homeostasis that are able to alter their phenotype in response to their surroundings and affect a wide range of biological processes. These properties make them critical to host function in normal and disease settings, leading …
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Role of Macrophage Apoptosis in Atherosclerosis.
… years. The majority of these apoptotic cells are macrophages. However, the pathogenic role of macrophage apoptosis in the development of atherosclerosis remains to be elucidated. Elevated expression of Bax, one of the pivotal pro-apoptotic proteins of the Bcl-2 family, has been found in human …
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Modulating macrophage phenotype for obesity therapy
… tissue which surrounds the internal organs. Macrophage cells are key mediators in this inflammation through crosstalk with adipocytes in adipose tissue. However, it is apparent that macrophages are also involved in beneficial metabolic processes like maintaining energy balance and directing …
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Macrophage-mediated regulation of joint homeostasis
… arthritic conditions is chronic synovitis. Macrophages are the main drivers of synovitis and can display pro-inflammatory (M1) or pro-resolving responses (M2). Macrophages promote joint health through phagocytic and secretory activities; however, when these functions are overwhelmed, …
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Lymphocyte-Macrophage interactions and resistance to Toxoplasmosis
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Studies on Macrophage Migration in Pathological Contexts
Macrophages play key roles following nerve injury releasing cytokines and chemokines thought to be involved in the development and maintenance of neuropathic pain. ATP is a transporter of chemical energy, but can also act as an extracellular signalling molecule that signals through purinergic …
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Distinguishing Macrophage Activation States by Mass Spectrometry
<p>Macrophages are versatile and highly adaptive cells that are involved in a wide range of physiological processes including host defense, homeostasis or regeneration, as well as pathogenesis. They react to their microenvironment, assuming various roles based on chemical and/or physical cues, and …
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Macrophage heterogeneity generated by differential gene expression
Restriction data tranferred 2014-07-01T11:19:49-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission
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Survival of Salmonella in the macrophage phagosome
… within host phagocytes, particularly macrophages. Salmonella requires an arsenal of virulence factors and defense mechanisms to survive the onslaught of host antimicrobial defenses that typically kill bacteria. One important antimicrobial defense is the oxidative burst, in which high …
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Tumor-induced macrophage and T cell dysfunction
Macrophages (MΦ) and T cells mediate helper, effector, and cytotoxic activities. Tumor growth changes the phenotypic and functional characteristics of MΦ and T cells and shifts them toward suppressor phenotypes and functional activities. Tumor growth changed MΦ DNA synthesis when activated through …
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The Interplay of Signal Transduction and Membrane Traffic of the Macrophage Colony Stimulating Factor Receptor (MCSFR) Controls Macrophage Growth
<p>Macrophage colony stimulating factor receptor (MCSFR a.k.a CSF-1R), is a receptor tyrosine kinase (RTK) that is essential for the growth of myeloid stem cells, monocytes and macrophages. Proper control of signaling through the MCSFR is critical for proper macrophage development and function. …
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The Effects of Rubulavirus Infection on Macrophage Function
THE EFFECTS OF RUBULAVIRUS INFECTION ON MACROPHAGE FUNCTION
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ROLE OF P50 NF-KB IN MACROPHAGE MIGRATION
Tumor Associated Macrophages (TAM) and lipopolisaccharide- (LPS)-tolerant macrophages share several characteristics, such as a massive accumulation of the p50 NF-B homodimer in the nucleus and the incapacity to express strong inflammatory programs (eg. impaired TNF production) in response to …
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Characterization of the Murine Macrophage Suppressor Factor (Msf)
… affect specific aspects of the immune process. Macrophage suppressor factor (MSF) is a lymphokine produced in the mouse spleen and is present in plasma. The in vitro target cell is the macrophage. The macrophage does not phagocytize as effectively in the presence of MSF. It was previously shown …
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Role of the macrophage in acute kidney injury
… specific treatments to promote renal recovery. Macrophages (Mφ) are pleiotropic cells of the innate immune system, with roles spanning host defence, cytotoxicity, clearance of apoptotic cells and promotion of tissue repair. Mφ are also known to be important mediators of renal injury in other …
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