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Showing 1 to 3 of 3 for “"macromolecular prodrugs"”.
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The characterisation of a fenoprofen prodrug
… can activate a prodrug via several routes. Prodrugs are mostly used to improve a drug's physical and chemical properties in order to optimise drug delivery. Not only can prodrugs prolong therapeutic effect, but sideeffects can also be minimised. Macromolecular prodrugs are one type of …
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Preparation, development and evaluation of novel drug delivery systems for colon targeting
… using TNBS colitis rat model were carried out. Macromolecular prodrugs of MTZ and α-, β- and γ-cyclodextrin or chitosan (CHT) were prepared by linking the drug with a covalent bond to the macromolecule (CD or CHT). All the prodrugs were chemically and analytically characterized. In vitro …
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Entwicklung von tumorhemmenden Polymer-Wirkstoff-Konjugaten des Zytostatikums Methotrexat auf der Basis von linearem Polyethylenglykol
Ziel dieser Arbeit war es, verschiedene Polymer-Wirkstoff-Konjugate bestehend aus dem Zytostatikum Methotrexat (MTX) und linearem Polyethylenglykol (PEG) zu synthetiseren und auf ihre tumorhemmenden Eigenschaften hin zu untersuchen. Aus diesen Ergebnissen sollten Struktur-Wirkungs-Beziehungen für …