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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"macrolides"”.
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Synthesis and function of the conserved motif of mycosamine-containing polyene macrolides
Mycosamine-containing polyene macrolides represent a large family of natural products with antifungal activity, of which amphotericin B (AmB) is an important member. Several of these clinically vital but toxic agents have been proposed to exert their biological activity through ion channel …
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Genomic insights into Group A Streptococcus pathogenesis
… high efficacy, alongside notable resistance to macrolides and tetracycline observed in LMICs; I demonstrate low levels of antimicrobial resistance in GAS in Cape Town, with most antibiotics being effective and only minimal resistance to macrolides and tetracycline; I report that GAS isolates …
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The determination of veterinary antibiotics in live animals and animal products
… foods of animal origin. The aminoglycosides and macrolides are two families of antibiotics that are very similar in structure and have important applications in veterinary medicine. These antibiotics are widely used in the treatment of bacterial infections e.g. aminoglycosides for enteritis and …
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Rationally designed aplyronine analogues for use in antibody-drug conjugates
… aplyronines are a family of antimitotic marine macrolides which show highly potent antiproliferative effects at picomolar concentrations in human cancer cell lines. Through a novel dual protein-targeting mechanism of action, their exquisite potency renders the aplyronines promising drug …
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Total Synthesis of Marine Macrolide Mangrolide D
… analogues as well as other structurally similar macrolides, like fidaxomicin and its analogues, for the purpose of new drug discovery.
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DISCOVERY OF NOVEL MACROLIDE ANTIBIOTICS AND METHODOLOGY DEVELOPMENT OF N-SULFINYL METALLODIENAMINES
… of A2058 leads to a steric clash with the macrolides and reduces the affinity of the macrolide for the ribosome. Thus, the bacterial resistant can be relieved via disrupting steric clashes between desosamine and A2058 residues. In 2017, I started a new project looking at the scope of the …
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Bronchektazės. Literatūros apžvalga ir klinikinis atvejis /
… mucoactive drugs, inhaled antibiotics, oral macrolides or their combination to the treatment plan is considered. Naturally, bronchiectasis tends to progress, worsen the quality of life, prognosis, and increase the risk of complications, so adherence to the optimal treatment plan and regular …
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Geographical Incidence of Antimicrobial Resistant Gonorrhea
… tetracycline, quinolones, and other macrolides, have once succeeded at curing gonorrhea. However, once resistance is built, gonorrhea then becomes untreatable. Currently, there are only two medications recommended in the treatment of gonococcal infections: Ceftriaxone injection and …
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Macrolide and lincosamide resistance patterns in invasive and colonizing group B streptococcus isolated in Belgium
… phenotypical and molecular surveillance of macrolides and lincosamides resistance patterns in Belgium has been conducted. Antimicrobial susceptilities to erythromycin and clindamycin were determined by Etest® (EUCAST interpretive criteria) on 275 clinical isolates (N1) obtained from the …
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An Investigation of Bacterial Ribonucleases as an Antibiotic Target
… Antibiotics such as aminoglycosides and macrolides specifically target the 30S or 50S subunits to inhibit bacterial growth. During the assembly of the bacterial ribosome, ribosomal RNA of the 30S and 50S ribosomal subunits is processed by bacterial ribonucleases (RNases). RNases are also …
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Mechanisms underlying polyene macrolide mediated rescue of growth in ion channel deficient yeast
… and uncharacterized small molecule polyene macrolides through biosynthetic gene cluster analysis. We hypothesized through interrogating the gene clusters of several, highly conserved domains including the aminotransferase, ketosynthase, etc. that we can identify novel producing organisms of …
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A Clinical Characteristics of Adverse Drug Reaction in Pediatrics
… patients, 18%), Cephalosporin (7 patients, 7%), Macrolides (3 patients, 3%), NSAID (13 patients, 13%), Acetaminophen (8 patients, 8%), Phenytoin (12 patients, 12%), Anti-cancer medicine (4 patients, 4%), Sedative (1 patient, 1%) and Antiflammatory (1 patient, 1%). For 16 patients among them, drug …
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Multivalent activation in temporary phosphate tethers: A new tether for small molecule synthesis
… the C1-C15 fragment of the dolabelide family of macrolides. Two routes were realized, both taking advantage of the protecting group aspect, and latent leaving group ability of the temporary phosphate tether, supplying the C15-C30 fragment in 12-steps from the bicyclic phosphate. Lastly, the use …
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Characterization of NfxB and PA4596, Two Repressors of the mexCD-oprJ Operon Encoding an RND-Type Multidrug Efflux Pump in Pseudomonas aeruginosa
… including fluoroquinolones, cephems, macrolides, and several biocides including chlorhexidine (CHX). Expression of mexCD-oprJ is negatively regulated by NfxB, a LacI-type repressor. The promoter region of mexCD-oprJ was identified and included two inverted repeat operator sites, B1 and …
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Designed analogues of the aplyronines for use in antibody-drug conjugates
… are a family of structurally complex marine macrolides, isolated from the sea hare Aplysia kurodai, that exhibit picomolar growth inhibitory activity in the NCI 60 cell line panel. An unprecedented heterotrimeric complex has been observed to form between aplyronine A and actin and tubulin …
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Excretion of Antibiotic Resistance Genes by Dairy Calves
… (tetC, tetG, tetO, tetW, and tetX), macrolides (ermB, ermF), and sulfonamides (sul1, sul2) classes of antibiotics along with the class I integron gene, intI1, were measured by quantitative polymerase chain reaction (qPCR). No tetC or intI was detected. There was no significant effect …
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Identifying cross-species regimens for the treatment of rapid-growing and slow-growing nontuberculous Mycobacterium pulmonary infections
… models of M. avium and M. abscessus infection. Macrolides, fluoroquinolones, and rifabutin demonstrated comparable in vitro potency, but had variable performance across models. Azithromycin and ofloxacin were also effective and displayed synergy when combined with bedaquiline. Combinations of …
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Synthesis, Screening and Cocrystallization of Adenosine Based Inhibitors with Methyltransferases, ErmC' and KsgA
… rRNA, conferring resistance to MLSB antibiotics (macrolides, lincosamides, streptogramin B). KsgA aids in ribosome assembly, binding inactive 30S until dimethylating A1518/A1519 of 16S rRNA. Like most methyltransferases, ErmC’ and KsgA use cofactor S-adenosylmethionine (SAM) as their methyl …
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ST-1 VISA/DAP-R CA-MRSA INTEGRATED OMICS: A FIRST REPORT OF HYPER-VIRULENCE AND MULTI-DRUG RESISTANT SUPERBUG
… of genes involved in aminoglycosides, β-lactams, macrolides and tetracyclines resistance, reflecting a multi-drug resistant behaviour. While the Virulome underlined the presence of adhesins, capsular polysaccharides, clumping factors, endotoxins, haemolysins, and leukotoxins including genes …
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