Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 71 for “"macrolide"”.
-
Macrolide Resistance in Mycobacterium avium
Mycobacterium avium isolates resistant to clarithromycin and azithromycin have been recovered from patients undergoing antibiotic therapy. Comparison of DNA fingerprints of sensitive and resistant isolates showed that resistance resulted from mutation of the original, sensitive isolate in five of …
-
Total Synthesis of Marine Macrolide Mangrolide D
… as a potential pathway to other glycosylated macrolide compounds. Meanwhile, we developed a concise synthetic route to access the rare and unique sugar moiety in mangrolide D, 4-epi-vancosamine, which had no reported synthetic protocols before. The synthesis of sugar moiety featured an …
-
Effects of Macrolide Antimicrobials on Anaerobic Treatment Systems
KEYWORDS: ADM1, anaerobic, macrolide, methanogenesis, storage, SBR, tylosin.
-
Evaluation of Macrolide-Lincosamide-Streptogramin B Antimicrobial Resistance at Swine Farms
… To better evaluate this concern, the levels of macrolide-lincosamide-streptogramin B (MLSB) antimicrobial resistance at swine farms were quantified. A variation of fluorescence in situ hybridization (FISH) was developed to detect the methylation of a specific adenine residue (A2058 in …
-
DISCOVERY OF NOVEL MACROLIDE ANTIBIOTICS AND METHODOLOGY DEVELOPMENT OF N-SULFINYL METALLODIENAMINES
… consists of two components: discovery of novel macrolide antibiotics and methodology development of N-sulfinyl metallodienamines. To tackle bacterial resistance, new antibiotics are desperately needed. My research objective is to address this need by designing, synthesizing, and evaluating novel …
-
Targeting the actin cytoskeleton in HER2+ metastatic cancer cells using a macrolide toxin
… this thesis, we tested the actin-depolymerizing macrolide toxin, Mycalolide B (MycB), as a potential warhead for a novel antibody drug conjugate (ADC) to target highly metastatic HER2+ breast and ovarian cancers. We found that MycB treatment of HER2+ breast (SKBR3, MDA-MB-453) and ovarian (SKOV3) …
-
Mechanisms underlying polyene macrolide mediated rescue of growth in ion channel deficient yeast
… pumps and transporters. AmB and other polyene macrolide ion channels are unregulated, unrectified, unselective, and passive. However, we hypothesized that through working together with H+-ATPases (drivers) and transporters (correctors) that imperfect small molecule ion channels are sufficient …
-
Effects of novel macrolide compounds on cell differentiation and barrier enhancement in colon epithelium
Iðrabólga er regnhlífarhugtak yfir bólgusjúkdóma í ristli og smáþörmum, en tvö megin form þess eru Crohn’s sjúkdómur og sáraristilbólga. Núverandi meðferðarmöguleikar eru meðal annars ónæmisstillandi lyf og sterar, en orsök sáraristilbólgu er ekki enn þekkt. Þekkt er að sýklalyfið Azithromycin …
-
Macrolide and lincosamide resistance patterns in invasive and colonizing group B streptococcus isolated in Belgium
… phenotypical and molecular surveillance of macrolides and lincosamides resistance patterns in Belgium has been conducted. Antimicrobial susceptilities to erythromycin and clindamycin were determined by Etest® (EUCAST interpretive criteria) on 275 clinical isolates (N1) obtained from the …
-
Characterization of a Macrolide Methyltransferase and Development of a Genetically-Encoded Biosensor for Polyketide Synthetic Biology.
North Carolina State University Theses Chemistry.
-
Non-Antibiotic Effects of Macrolide Antibiotics of the Oleandomycin-Erythromycin Group With Special Reference to Their "Steroid-sparing" Effects
… the effectiveness of triacetyloleandomycin, a macrolide antibiotic, in the treatment of bronchial asthma. The beneficial effects were attributed to the antimicrobial characteristics of this compound. However, the antiasthmatic activity of the drug was found by Towniey et al. 14-18 to be …
-
Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in a university medical center day care facility
… Univariate analysis identified macrolide antibiotics (p=0.004), asthma medications (p=0.036), other medications (p=0.036), and previous surgery (p=0.022) as risk factors. On multivariable analysis, receipt of macrolide antibiotics (p=0.002; OR 39.6; 95% CI 3.4-651.4), and receipt …
-
Expression, Reinigung und Charakterisierung von Makrolid-Glykosyltransferasen für die Synthese neuartiger Makrolid-Antibiotika
The macrolide glycosyltransferases EryCIII, EryBV, OleG2 and TylMII were produced by medium-scale fermentation of recombinant Saccharopolyspora erythraea strains. The soluble expression of all glycosyltransferase genes was verified by immunoblotting and ELISA against the C-terminal …
-
Molecular analysis of the extrachromosomal elements of Lactobacillus acidophilus strain 100-33
… Strain 100-33 has antibiotic resistance to macrolide, lincosamide, and streptogramin B-type antibiotics (MLS$\sp{\rm R}$) and tetracycline. Transformants with altered plasmid profiles had also become sensitive to the MLS antibiotics (McCarthy et al, 1988).
-
Mecanismos de resistencia a antibióticos macrólidos, lincosamidas y estreptograminas en streptococcus y enterococcus
Objetive: Characterization of macrolide, lincosamide and streptogramin (MLS) resistance mechanisms in Streptococcus and Enterococcus in La Rioja, from 1996 to 2001. Distribution of erythromcyin resistance phenotypes and involved mechanisms were studied for both genera, as well as temporary …
-
The use of chiral auxiliaries in the synthesis of chemically and biologically important chiral compunds
… Department at the University of Michigan, the macrolide core (10) of lactimidomycin was synthesised for biological evaluation over 11-linear steps in a 6.1 % overall yield. The synthesis exploited an Evans' oxazolidinonemediated aldol reaction to construct the Evans syn-adduct, a Suzuki …
Page 1 of 4