Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 203 for “"macrocyclic"”.
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Synthesis of macrocyclic azapolyethers
Not available
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Design and Synthesis of a Macrocyclic Phospholipid
… and synthesis of a synthetic membrane-spanning macrocyclic lipid to test this hypothesis. Protected glutaric anhydride reacted with 10-undecyn-1-ol to produce a glutarate monoester. Copper-mediated azide-alkyne coupling (CuAAC) using 1,5-diazido-3-oxapentane(bis-azide) afforded a …
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Total synthesis of macrocyclic bisbibenzyl natural products
… with the total synthesis of two related macrocyclic natural products, cavicularin and riccardin C. Cavicularin is particularly noteworthy owing to its interesting structure: its 14-membered macrocyclic core imparts sufficient strain on the system to force one of the arenes in this …
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Magnetically Interesting Coordination Complexes Based on Macrocyclic Ligands
… the discovery and study of new families of macrocyclic-based single molecule magnets (SMMs). Chapter 1 introduces the general theory of magnetism, molecular magnetism and SMMs and provides the reader with a brief overview of the relevant coordination chemistry of the two families of …
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Macrocyclic Monomers: Synthesis, Characterization and Ring-opening Polymerization
Interest in macrocyclic monomers can be dated back to the 1960's. The recent surge of research activities in this area is prompted by two facts: the encouraging discovery of high yield synthesis and facile ring-opening polymerization of cyclic polycarbonate; the need for a technique to solve the …
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Macrocyclic Polyamines and Their Metal Complexes Targeting HIV-1
M40401 is a well known antioxidant and as of late, it has been studied for anti- HIV properties. It was reported to reduce apoptosis of astrocytes caused by HIV- 1 infected macrophages (M/M) supernatants, and in 2005, a poster presented at the International Conference for Antiviral Research claimed …
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Discovery of macrocyclic inhibitors of challenging protein-protein interactions
Macrocycles are a therapeutic modality of interest for drugging challenging disease targets due to their high binding affinity and membrane permeability, enabling the discovery of orally delivered and efficacious therapeutics. Recent methods have enabled the purification-free synthesis of …
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Directed Evolution of Macrocyclic Peptides For Inhibition of Autophagy
… Resistant (SUPR) mRNA display to develop macrocyclic peptides targeting the autophagy protein LC3. The resulting peptides bound LC3A and LC3B—two essential components of the autophagosome maturation machinery—with mid-nanomolar affinities and disrupted protein-protein interactions (PPIs) …
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An efficient algorithm for conformational search of macrocyclic molecules
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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Studies directed towards the synthesis of the macrocyclic lactone Aspicilin
Contains fulltext : 30119_studditot.pdf (Publisher’s version ) (Open Access)
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Studies of the metal-binding sites in macrocyclic quadridentate ligands
The preparations of quadridentate macrocyclic ligands with N4-, O2N2- and S2N2-donor-sets are described.
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Stability evaluation of selected anthelmintic macrocyclic lactone compounds and formulations
… are used for control of these parasites. Macrocyclic lactone (ML) compounds such as avermectins (e.g. abamectin, ivermectin, eprinomectin) and milbemycins (e.g. milbemycin oxime and moxidectin) are among most important anthelmintics, used extensively and globally. However, excessive and …
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Metal Complexes of Fourteen-Membered Macrocyclic Ligands Containing Tertiary Amine Donors
Made available in DSpace on 2014-12-13T20:09:48Z (GMT). No. of bitstreams: 1 7607004.pdf: 6033610 bytes, checksum: e74be4a28edcc1a186ddfcbb3f73c9dd (MD5) Previous issue date: 1975
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Synthesis of novel pendant arm macrocyclic ligands as potential models for enterobactin
A series of pendant arm tris-catecholate macrocyclic ligands were synthesized. The first, based on 1,4,7- triaminopropyl-1, 4, 7-triazacyclononane, was prepared via condensation with 2,3-dimethoxybenzoyl chloride. The deprotection of the catechol moieties was achieved with boron tribromide in 80% …
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