Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"mTORC"”.
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Studies of amino acid sensing by the mTORC 1 pathway
The mTOR complex 1 (mTORC 1) protein kinase is a master growth regulator that responds to multiple cues from the local and systemic environment surrounding the cell. Nutrients and growth factors are both required to activate mTORC 1 and to promote growth. While the mechanisms of growth factor …
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Daily organisation of cellular physiology by mTOR kinase
… the mechanistic target of rapamycin complex (mTORC) activity exhibits daily rhythms both in vivo and in cultured cells. Circadian rhythms are sensitive to changes in mTORC activity, moreover, many circadian-regulated process are directly or indirectly sensitive to changes in mTORC activity …
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The role of mammalian target of rapamycin complex 1 in hepatic physiology and disease
The multi-component kinase mTOR complex 1 (mTORC 1) coordinates nutrient and growth factor inputs with numerous downstream processes including protein translation, autophagy, metabolism and cell growth. We have found that inhibition of mTORC 1 with rapamycin treatment suppressed whole-body …
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Identifying genes that are required for the maintenance of pancreatic ductal adenocarcinoma
… inhibition of mTOR results in downregulation of mTORCl and mTORC2 targets, while inhibition of Raptor induces downregulation of only mTORC 1 targets. As combination therapies are likely to be more effective, we looked for a drug that could combine effectively with mTOR and Raptor. From screening …
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The role of Rnd3 in kidney morphogenesis and function
… to result in the destabilisation of the cAMP-PKA-mTORC-1 signalling cascade, which contributes towards the onset and development of polycystic kidneys, mimicking ADPKD.
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Identification of mechanisms of gemcitabine resistance using a whole genome shRNA screen in a novel in vitro coculture model of pancreatic cancer.
… phenotype, representing pathways such as MTORC signalling and DNA damage response. This dataset serves as the first shRNA-mediated coculture screen for gemcitabine resistance in PDAC. My findings lay credence to the value of this model of gemcitabine resistance for preclinical use and …
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Selective Neuronal Vulnerability in Neocortices from Patients with C9ORF72-related Neurodegeneration
… upon metaanalysis, and suggest a role for mTORC signalling. Importantly, I also observed that existing c9HRE model systems may not be appropriate for understanding post-mortem changes. In summary, this work suggests that selective vulnerability in c9HRE is determined by (and possibly …
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Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
… Tyrosine kinase receptor-mediated PI3K-Akt-mTORC signaling cascades have been studied for their role in maintaining HSV latency. Activation of β-catenin signalosome expression has also been implicated during HSV latency and following reactivation. GSK3β is a key effector molecule that …
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Prevalence of Premature Ovarian Failure In Women With Tuberous Sclerosis
<p> Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor suppressor disorder characterized by hamartomas, or benign growths, in various organ systems. Inactivating mutations in either the <em>TSC1</em> or the <em>TSC2</em> gene cause most cases of TSC. Recently, the use of ovarian …