Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"mTOR signaling"”.
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Genetic Analysis of the PI3K/AKT/mTOR Signaling Pathway
… fundamentally attributable to dysfunctional cell signaling. The PI3K/AKT/mTOR pathway is an important pro-growth intracellular signaling cascade that is often inappropriately activated in a wide array of cancers. Efforts to develop anticancer drugs have therefore focused, in part, on identifying …
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BMPR2 and mTOR Signaling Pathways in Inflammatory Lung Diseases
… (BMPR2) and the mammalian target of rapamycin (mTOR) signaling pathways in the pathogenesis of PAH and asthma, respectively. Previous studies have indicated mutations in BMPR2 as one of the contributing factors in the pathogenesis of the heritable form of PAH. Although BMPR2 mutations have been …
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The role of mTOR signaling in Alzheimer s disease
… activity of the mammalian target of rapamycin (mTOR) increases lifespan and health-span in several genetically different species. mTOR is a ubiquitously expressed protein kinase that plays a key role in regulating protein synthesis and cell growth. mTOR also is a negative regulator of autophagy …
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mTOR Signaling in Cellular Growth and Skeletal Muscle Maturation
A Serine/Threonine kinase, mTOR, is a cellular target of rapamycin and plays a role in cellular growth and proliferation by regulating translation through the phosphorylation of 4E-BP1 and S6K. Here, I investigated the function of mTOR for the activation of newly found S6K1 homologue, S6K2, and for …
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Regulation of skeletal myogenesis by the mTOR signaling network
… environmental cues and regulated by distinct signaling pathways, resulting in the activation of specific transcription factors and subsequent reprogramming of gene expression. The mammalian target of rapamycin (mTOR) is a Ser/Thr kinase that controls a wide spectrum of cellular and …
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Molecular Mechanism of Insulin Resistance: Role of mTOR Signaling Pathways
… Chapter IV, I describe another investigation of mTOR signaling mechanisms. In this study I initially set out to identify nuclear export signals in mTOR. A systematic scan of the mTOR sequence revealed 16 peptides conforming to the canonical leucine-rich nuclear export signal, of which 3 were …
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AMP-activated protein kinase-mTOR signaling pathway and hepatitis B virus replication
… 증식을 위해서는 AMPK의 억제와mammalian target of rapamycin(mTOR)의 활성이 필요하며 이를 통해 바이러스 복제에 필요한 지질을 합성한다. HBV X 단백질(HBx)은 mTOR의 활성을 증가시켜 hepatocellular carcinoma(HCC) 세포의 증식을 유도한다. 본 연구에서는 HBV가 증식할 때 AMPK와 mTOR의 활성에 변화가 있는지 알아보았고, AMPK-mTOR 신호전달 과정의 변화가 HBV 증식에 영향을 미치는지 알아보고자 하였다. HCC 세포인 HepG2세포에서 유래한 HBV 가 …
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Investigating the Potential of Microbial Metabolites and mTOR Signaling on Chicken Necrotic Enteritis
… the third chapter, we investigated if blocking mTOR can modulate the NE induced intestinal inflammation. It has been established that the mammalian target of Rapamycin (mTOR) inhibitors has anti-inflammatory effects in models of experimental colitis. However, its impact on necrotic enteritis …
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Insights into the regulation of mTOR signaling and the consequences of pharmacological inhibition
… catalytic domain. In mammals, the TORC2 homolog mTORC2 is activated by growth factors through the lipid kinase PI3K, and is a primary effector for many of its functions, including regulation of the proliferation and survival kinase Akt/PKB. Activation of PI3K also leads to activation of mTORC1. …
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Targeting Akt/Mtor Signaling Pathways During Murine Skin Tumor Promotion and The Impact of Dietary Energy Balance Manipulation
… Previous data has demonstrated differential signaling through Akt and mTOR via the IGF-1R and other growth factor receptors across the diet-induced obesity (DIO)/CR spectrum. Furthermore, mTORC1 is known to be regulated directly via nutrient availability, supporting its role in the link …
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The impact of supplemental vitamin D on motor learning and seizures in mice with hyperactive mTOR induced epilepsy and ataxia.
Genetic mutations that cause hyperactive mTOR signaling in the cerebellum lead to disrupted cerebellar growth, debilitating motor impairments, and may contribute to the development of epilepsy. mTOR inhibitors can reduce seizures and may prevent behavioral impairments but are associated with …
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The Impact Of Folate Restriction On Cancer And Aging: A Mechanistic Analysis
… They impact a major nutrient sensing pathway, mTOR. mTOR signaling is altered in many cancers and its downregulation was shown to delay aging. Other interventions extend lifespan by altering the one carbon metabolism. In this study, we present folate restriction as a possible nutritional …
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Regulation of mTORC1 by phosphatidic acid: mechanism and structural insight
The mammalian target of rapamycin (mTOR) is a Ser/Thr kinase with remarkable control over cellular status. As a master regulator, mTOR integrates a variety of intra- and extra-cellular signals in order to coordinate them with appropriate gene expression, protein synthesis, metabolism, cell …
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Regulation of Skeletal Muscle Differentiation by a Rapamycin -Sensitive Signaling Pathway
… gain further insight into myogenic regulation of mTOR, the structure-function relationship of mTOR was examined by a series of truncation and deletion mutants. Strikingly, the results indicate that the C-terminal 1187 amino acids are sufficient for mTOR's myogenic function and the N-terminal half …
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Combating Resistance To Epidermal Growth Factor Recpetor Inhibitors In Triple Negative Breast Cancer
… presence of GEF, we found that components of the mTOR signaling pathway remain phosphorylated. While inhibiting mTOR with temsirolimus (TEM) decreased mTOR signaling, EGFR signaling pathways remained activated and the TNBC cell lines continued to proliferate. However, dual treatment with TEM and …
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Non-proteolytic roles of the ubiquitin-proteasome system in memory formation across the lifespan
… such as histone monoubiquitination and ubiquitin signaling, have emerged as key players in these processes. While monoubiquitination of histone H2B is a well-established regulator of increased gene transcription in memory formation, the role of histone H2A monoubiquitination (H2Aubi), a potent …
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REGULATION OF T CELLS AND TISSUE INFLAMMATION BY SHORT CHAIN FATTY ACIDS
… and upregulated acetylation of p70 S6 kinase and mTOR activation in T cells. We also found that prolonged exposure to high concentration of SCFA cause ureteral obstruction and hydronephrosis. SCFAs activated mTOR signaling in renal T cells and developed T cell-mediated inflammation in the ureter …
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The Cancer Specific Ubiquitin Ligase MAGE-A3/6-TRIM28 Drives Tumorigenesis by Ubiquitination and Proteasomal Degradation of AMPK
… its proteasomal degradation, thereby enhancing mTOR signaling and inhibiting autophagy within cells. Through this modulation of AMPK, MAGE-A3/6 is also able to act as an oncogene, inducing anchorage independent growth and the growth of tumors in vivo. Understanding the mechanism by which …
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Ras Drives Malignancy Through Stem Cell Crosstalk with the Microenvironment
… are triggered by marked elevation of RAS/MAPK signaling and progression from benign papilloma to invasive malignancy. A subset of tumor-initiating basal progenitors, the cancer stem cells, obtain increased resistance to chemo and immunotherapy along this path. However, the distribution and …
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Genomic Profiling of Alternative splicing in liver cancer
… adhesion, regulation of actin cytoskeleton and mTOR signaling pathway. Especially, alternative splicing of WNT5A gene depending on HCC subtype was found, which may reflect the recurrence and progression. This study supposed that using classification based on the profile of alternative splicing …
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